9I3U

Cryo-EM structure of the AGR2 dimer in complex with the monomeric IRE1beta luminal domain

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002162	molecular_function	dystroglycan binding
B	0005154	molecular_function	epidermal growth factor receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005783	cellular_component	endoplasmic reticulum
B	0006954	biological_process	inflammatory response
B	0010628	biological_process	positive regulation of gene expression
B	0010811	biological_process	positive regulation of cell-substrate adhesion
B	0030968	biological_process	endoplasmic reticulum unfolded protein response
B	0034975	biological_process	protein folding in endoplasmic reticulum
B	0034976	biological_process	response to endoplasmic reticulum stress
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
B	0048546	biological_process	digestive tract morphogenesis
B	0048639	biological_process	positive regulation of developmental growth
B	0060326	biological_process	cell chemotaxis
B	0070254	biological_process	mucus secretion
B	1903078	biological_process	positive regulation of protein localization to plasma membrane
B	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
B	1903899	biological_process	positive regulation of PERK-mediated unfolded protein response
D	0002162	molecular_function	dystroglycan binding
D	0005154	molecular_function	epidermal growth factor receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005783	cellular_component	endoplasmic reticulum
D	0006954	biological_process	inflammatory response
D	0010628	biological_process	positive regulation of gene expression
D	0010811	biological_process	positive regulation of cell-substrate adhesion
D	0030968	biological_process	endoplasmic reticulum unfolded protein response
D	0034975	biological_process	protein folding in endoplasmic reticulum
D	0034976	biological_process	response to endoplasmic reticulum stress
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
D	0048546	biological_process	digestive tract morphogenesis
D	0048639	biological_process	positive regulation of developmental growth
D	0060326	biological_process	cell chemotaxis
D	0070254	biological_process	mucus secretion
D	1903078	biological_process	positive regulation of protein localization to plasma membrane
D	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
D	1903899	biological_process	positive regulation of PERK-mediated unfolded protein response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Motif: {"description":"Homodimer stabilization; interchain","evidences":[{"source":"PubMed","id":"23274113","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2LNS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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