9I2B

SPIN90-Arp2/3 nucleated bidirectional actin filaments

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003779	molecular_function	actin binding
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005885	cellular_component	Arp2/3 protein complex
A	0005903	cellular_component	brush border
A	0005911	cellular_component	cell-cell junction
A	0005925	cellular_component	focal adhesion
A	0007163	biological_process	establishment or maintenance of cell polarity
A	0008356	biological_process	asymmetric cell division
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0015629	cellular_component	actin cytoskeleton
A	0016020	cellular_component	membrane
A	0016344	biological_process	meiotic chromosome movement towards spindle pole
A	0030027	cellular_component	lamellipodium
A	0030030	biological_process	cell projection organization
A	0033206	biological_process	meiotic cytokinesis
A	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
A	0035861	cellular_component	site of double-strand break
A	0042995	cellular_component	cell projection
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051015	molecular_function	actin filament binding
A	0051321	biological_process	meiotic cell cycle
A	0051653	biological_process	spindle localization
A	0060271	biological_process	cilium assembly
A	0070062	cellular_component	extracellular exosome
A	0070358	biological_process	actin polymerization-dependent cell motility
A	0071346	biological_process	cellular response to type II interferon
B	0000166	molecular_function	nucleotide binding
B	0003779	molecular_function	actin binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005885	cellular_component	Arp2/3 protein complex
B	0005925	cellular_component	focal adhesion
B	0005938	cellular_component	cell cortex
B	0007163	biological_process	establishment or maintenance of cell polarity
B	0008356	biological_process	asymmetric cell division
B	0010592	biological_process	positive regulation of lamellipodium assembly
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0016344	biological_process	meiotic chromosome movement towards spindle pole
B	0016482	biological_process	cytosolic transport
B	0030036	biological_process	actin cytoskeleton organization
B	0030478	cellular_component	actin cap
B	0033206	biological_process	meiotic cytokinesis
B	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
B	0035578	cellular_component	azurophil granule lumen
B	0035861	cellular_component	site of double-strand break
B	0042995	cellular_component	cell projection
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051015	molecular_function	actin filament binding
B	0051321	biological_process	meiotic cell cycle
B	0051653	biological_process	spindle localization
B	0060271	biological_process	cilium assembly
B	0070062	cellular_component	extracellular exosome
B	0071346	biological_process	cellular response to type II interferon
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	2001032	biological_process	regulation of double-strand break repair via nonhomologous end joining
C	0003779	molecular_function	actin binding
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005885	cellular_component	Arp2/3 protein complex
C	0005925	cellular_component	focal adhesion
C	0015629	cellular_component	actin cytoskeleton
C	0032355	biological_process	response to estradiol
C	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
C	0036284	cellular_component	tubulobulbar complex
C	0043627	biological_process	response to estrogen
C	0044877	molecular_function	protein-containing complex binding
C	0051015	molecular_function	actin filament binding
C	0070062	cellular_component	extracellular exosome
D	0003779	molecular_function	actin binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005768	cellular_component	endosome
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005885	cellular_component	Arp2/3 protein complex
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0010592	biological_process	positive regulation of lamellipodium assembly
D	0015629	cellular_component	actin cytoskeleton
D	0030027	cellular_component	lamellipodium
D	0030672	cellular_component	synaptic vesicle membrane
D	0030838	biological_process	positive regulation of actin filament polymerization
D	0031252	cellular_component	cell leading edge
D	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
D	0035861	cellular_component	site of double-strand break
D	0036195	cellular_component	muscle cell projection membrane
D	0042995	cellular_component	cell projection
D	0043005	cellular_component	neuron projection
D	0044089	biological_process	positive regulation of cellular component biogenesis
D	0045202	cellular_component	synapse
D	0051015	molecular_function	actin filament binding
D	0051130	biological_process	positive regulation of cellular component organization
D	0070062	cellular_component	extracellular exosome
D	0070358	biological_process	actin polymerization-dependent cell motility
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
E	0003779	molecular_function	actin binding
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005885	cellular_component	Arp2/3 protein complex
E	0005925	cellular_component	focal adhesion
E	0015629	cellular_component	actin cytoskeleton
E	0016020	cellular_component	membrane
E	0030027	cellular_component	lamellipodium
E	0031252	cellular_component	cell leading edge
E	0031941	cellular_component	filamentous actin
E	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
E	0035861	cellular_component	site of double-strand break
E	0042995	cellular_component	cell projection
E	0051015	molecular_function	actin filament binding
E	0061850	cellular_component	growth cone leading edge
E	0070062	cellular_component	extracellular exosome
E	0070358	biological_process	actin polymerization-dependent cell motility
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
E	1990090	biological_process	cellular response to nerve growth factor stimulus
F	0003779	molecular_function	actin binding
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005885	cellular_component	Arp2/3 protein complex
F	0019899	molecular_function	enzyme binding
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
F	0035861	cellular_component	site of double-strand break
F	0042995	cellular_component	cell projection
F	0045010	biological_process	actin nucleation
F	0051015	molecular_function	actin filament binding
F	0070062	cellular_component	extracellular exosome
G	0003779	molecular_function	actin binding
G	0005515	molecular_function	protein binding
G	0005856	cellular_component	cytoskeleton
G	0005885	cellular_component	Arp2/3 protein complex
G	0005925	cellular_component	focal adhesion
G	0016477	biological_process	cell migration
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0030863	cellular_component	cortical cytoskeleton
G	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
G	0045202	cellular_component	synapse
G	0070062	cellular_component	extracellular exosome
G	0098978	cellular_component	glutamatergic synapse
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005829	cellular_component	cytosol
H	0005882	cellular_component	intermediate filament
H	0005886	cellular_component	plasma membrane
H	0006897	biological_process	endocytosis
H	0007010	biological_process	cytoskeleton organization
H	0008092	molecular_function	cytoskeletal protein binding
H	0008180	cellular_component	COP9 signalosome
H	0010976	biological_process	positive regulation of neuron projection development
H	0017124	molecular_function	SH3 domain binding
H	0071933	molecular_function	Arp2/3 complex binding
H	0098794	cellular_component	postsynapse
H	0098978	cellular_component	glutamatergic synapse
H	0150052	biological_process	regulation of postsynapse assembly
I	0000166	molecular_function	nucleotide binding
I	0000786	cellular_component	nucleosome
I	0001738	biological_process	morphogenesis of a polarized epithelium
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005884	cellular_component	actin filament
I	0005886	cellular_component	plasma membrane
I	0005903	cellular_component	brush border
I	0005911	cellular_component	cell-cell junction
I	0005912	cellular_component	adherens junction
I	0005925	cellular_component	focal adhesion
I	0007163	biological_process	establishment or maintenance of cell polarity
I	0007409	biological_process	axonogenesis
I	0015629	cellular_component	actin cytoskeleton
I	0016020	cellular_component	membrane
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0019894	molecular_function	kinesin binding
I	0019901	molecular_function	protein kinase binding
I	0030027	cellular_component	lamellipodium
I	0030235	molecular_function	nitric-oxide synthase regulator activity
I	0030424	cellular_component	axon
I	0030863	cellular_component	cortical cytoskeleton
I	0030957	molecular_function	Tat protein binding
I	0032991	cellular_component	protein-containing complex
I	0034333	biological_process	adherens junction assembly
I	0035267	cellular_component	NuA4 histone acetyltransferase complex
I	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
I	0042802	molecular_function	identical protein binding
I	0043296	cellular_component	apical junction complex
I	0044305	cellular_component	calyx of Held
I	0045176	biological_process	apical protein localization
I	0045202	cellular_component	synapse
I	0048870	biological_process	cell motility
I	0050998	molecular_function	nitric-oxide synthase binding
I	0051621	biological_process	regulation of norepinephrine uptake
I	0051726	biological_process	regulation of cell cycle
I	0070160	cellular_component	tight junction
I	0071896	biological_process	protein localization to adherens junction
I	0072749	biological_process	cellular response to cytochalasin B
I	0097433	cellular_component	dense body
I	0098685	cellular_component	Schaffer collateral - CA1 synapse
I	0098871	cellular_component	postsynaptic actin cytoskeleton
I	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
I	0098974	biological_process	postsynaptic actin cytoskeleton organization
I	0098978	cellular_component	glutamatergic synapse
I	0141108	molecular_function	transporter regulator activity
I	0150111	biological_process	regulation of transepithelial transport
I	1900242	biological_process	regulation of synaptic vesicle endocytosis
I	1903076	biological_process	regulation of protein localization to plasma membrane
I	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
I	1990904	cellular_component	ribonucleoprotein complex
J	0000166	molecular_function	nucleotide binding
J	0000786	cellular_component	nucleosome
J	0001738	biological_process	morphogenesis of a polarized epithelium
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005884	cellular_component	actin filament
J	0005886	cellular_component	plasma membrane
J	0005903	cellular_component	brush border
J	0005911	cellular_component	cell-cell junction
J	0005912	cellular_component	adherens junction
J	0005925	cellular_component	focal adhesion
J	0007163	biological_process	establishment or maintenance of cell polarity
J	0007409	biological_process	axonogenesis
J	0015629	cellular_component	actin cytoskeleton
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0019894	molecular_function	kinesin binding
J	0019901	molecular_function	protein kinase binding
J	0030027	cellular_component	lamellipodium
J	0030235	molecular_function	nitric-oxide synthase regulator activity
J	0030424	cellular_component	axon
J	0030863	cellular_component	cortical cytoskeleton
J	0030957	molecular_function	Tat protein binding
J	0032991	cellular_component	protein-containing complex
J	0034333	biological_process	adherens junction assembly
J	0035267	cellular_component	NuA4 histone acetyltransferase complex
J	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
J	0042802	molecular_function	identical protein binding
J	0043296	cellular_component	apical junction complex
J	0044305	cellular_component	calyx of Held
J	0045176	biological_process	apical protein localization
J	0045202	cellular_component	synapse
J	0048870	biological_process	cell motility
J	0050998	molecular_function	nitric-oxide synthase binding
J	0051621	biological_process	regulation of norepinephrine uptake
J	0051726	biological_process	regulation of cell cycle
J	0070160	cellular_component	tight junction
J	0071896	biological_process	protein localization to adherens junction
J	0072749	biological_process	cellular response to cytochalasin B
J	0097433	cellular_component	dense body
J	0098685	cellular_component	Schaffer collateral - CA1 synapse
J	0098871	cellular_component	postsynaptic actin cytoskeleton
J	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
J	0098974	biological_process	postsynaptic actin cytoskeleton organization
J	0098978	cellular_component	glutamatergic synapse
J	0141108	molecular_function	transporter regulator activity
J	0150111	biological_process	regulation of transepithelial transport
J	1900242	biological_process	regulation of synaptic vesicle endocytosis
J	1903076	biological_process	regulation of protein localization to plasma membrane
J	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
J	1990904	cellular_component	ribonucleoprotein complex
K	0000166	molecular_function	nucleotide binding
K	0003779	molecular_function	actin binding
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005885	cellular_component	Arp2/3 protein complex
K	0005903	cellular_component	brush border
K	0005911	cellular_component	cell-cell junction
K	0005925	cellular_component	focal adhesion
K	0007163	biological_process	establishment or maintenance of cell polarity
K	0008356	biological_process	asymmetric cell division
K	0010592	biological_process	positive regulation of lamellipodium assembly
K	0015629	cellular_component	actin cytoskeleton
K	0016020	cellular_component	membrane
K	0016344	biological_process	meiotic chromosome movement towards spindle pole
K	0030027	cellular_component	lamellipodium
K	0030030	biological_process	cell projection organization
K	0033206	biological_process	meiotic cytokinesis
K	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
K	0035861	cellular_component	site of double-strand break
K	0042995	cellular_component	cell projection
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0051015	molecular_function	actin filament binding
K	0051321	biological_process	meiotic cell cycle
K	0051653	biological_process	spindle localization
K	0060271	biological_process	cilium assembly
K	0070062	cellular_component	extracellular exosome
K	0070358	biological_process	actin polymerization-dependent cell motility
K	0071346	biological_process	cellular response to type II interferon
L	0000166	molecular_function	nucleotide binding
L	0003779	molecular_function	actin binding
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005885	cellular_component	Arp2/3 protein complex
L	0005925	cellular_component	focal adhesion
L	0005938	cellular_component	cell cortex
L	0007163	biological_process	establishment or maintenance of cell polarity
L	0008356	biological_process	asymmetric cell division
L	0010592	biological_process	positive regulation of lamellipodium assembly
L	0015629	cellular_component	actin cytoskeleton
L	0016020	cellular_component	membrane
L	0016344	biological_process	meiotic chromosome movement towards spindle pole
L	0016482	biological_process	cytosolic transport
L	0030036	biological_process	actin cytoskeleton organization
L	0030478	cellular_component	actin cap
L	0033206	biological_process	meiotic cytokinesis
L	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
L	0035578	cellular_component	azurophil granule lumen
L	0035861	cellular_component	site of double-strand break
L	0042995	cellular_component	cell projection
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0051015	molecular_function	actin filament binding
L	0051321	biological_process	meiotic cell cycle
L	0051653	biological_process	spindle localization
L	0060271	biological_process	cilium assembly
L	0070062	cellular_component	extracellular exosome
L	0071346	biological_process	cellular response to type II interferon
L	1904813	cellular_component	ficolin-1-rich granule lumen
L	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
L	2001032	biological_process	regulation of double-strand break repair via nonhomologous end joining
M	0003779	molecular_function	actin binding
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005885	cellular_component	Arp2/3 protein complex
M	0005925	cellular_component	focal adhesion
M	0015629	cellular_component	actin cytoskeleton
M	0032355	biological_process	response to estradiol
M	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
M	0036284	cellular_component	tubulobulbar complex
M	0043627	biological_process	response to estrogen
M	0044877	molecular_function	protein-containing complex binding
M	0051015	molecular_function	actin filament binding
M	0070062	cellular_component	extracellular exosome
N	0003779	molecular_function	actin binding
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005768	cellular_component	endosome
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005885	cellular_component	Arp2/3 protein complex
N	0005886	cellular_component	plasma membrane
N	0005925	cellular_component	focal adhesion
N	0010592	biological_process	positive regulation of lamellipodium assembly
N	0015629	cellular_component	actin cytoskeleton
N	0030027	cellular_component	lamellipodium
N	0030672	cellular_component	synaptic vesicle membrane
N	0030838	biological_process	positive regulation of actin filament polymerization
N	0031252	cellular_component	cell leading edge
N	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
N	0035861	cellular_component	site of double-strand break
N	0036195	cellular_component	muscle cell projection membrane
N	0042995	cellular_component	cell projection
N	0043005	cellular_component	neuron projection
N	0044089	biological_process	positive regulation of cellular component biogenesis
N	0045202	cellular_component	synapse
N	0051015	molecular_function	actin filament binding
N	0051130	biological_process	positive regulation of cellular component organization
N	0070062	cellular_component	extracellular exosome
N	0070358	biological_process	actin polymerization-dependent cell motility
N	0098793	cellular_component	presynapse
N	0098794	cellular_component	postsynapse
N	0098978	cellular_component	glutamatergic synapse
N	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
O	0003779	molecular_function	actin binding
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005885	cellular_component	Arp2/3 protein complex
O	0005925	cellular_component	focal adhesion
O	0015629	cellular_component	actin cytoskeleton
O	0016020	cellular_component	membrane
O	0030027	cellular_component	lamellipodium
O	0031252	cellular_component	cell leading edge
O	0031941	cellular_component	filamentous actin
O	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
O	0035861	cellular_component	site of double-strand break
O	0042995	cellular_component	cell projection
O	0051015	molecular_function	actin filament binding
O	0061850	cellular_component	growth cone leading edge
O	0070062	cellular_component	extracellular exosome
O	0070358	biological_process	actin polymerization-dependent cell motility
O	1900242	biological_process	regulation of synaptic vesicle endocytosis
O	1990090	biological_process	cellular response to nerve growth factor stimulus
P	0003779	molecular_function	actin binding
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005885	cellular_component	Arp2/3 protein complex
P	0019899	molecular_function	enzyme binding
P	0030674	molecular_function	protein-macromolecule adaptor activity
P	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
P	0035861	cellular_component	site of double-strand break
P	0042995	cellular_component	cell projection
P	0045010	biological_process	actin nucleation
P	0051015	molecular_function	actin filament binding
P	0070062	cellular_component	extracellular exosome
Q	0003779	molecular_function	actin binding
Q	0005515	molecular_function	protein binding
Q	0005856	cellular_component	cytoskeleton
Q	0005885	cellular_component	Arp2/3 protein complex
Q	0005925	cellular_component	focal adhesion
Q	0016477	biological_process	cell migration
Q	0030674	molecular_function	protein-macromolecule adaptor activity
Q	0030863	cellular_component	cortical cytoskeleton
Q	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
Q	0045202	cellular_component	synapse
Q	0070062	cellular_component	extracellular exosome
Q	0098978	cellular_component	glutamatergic synapse
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005829	cellular_component	cytosol
R	0005882	cellular_component	intermediate filament
R	0005886	cellular_component	plasma membrane
R	0006897	biological_process	endocytosis
R	0007010	biological_process	cytoskeleton organization
R	0008092	molecular_function	cytoskeletal protein binding
R	0008180	cellular_component	COP9 signalosome
R	0010976	biological_process	positive regulation of neuron projection development
R	0017124	molecular_function	SH3 domain binding
R	0071933	molecular_function	Arp2/3 complex binding
R	0098794	cellular_component	postsynapse
R	0098978	cellular_component	glutamatergic synapse
R	0150052	biological_process	regulation of postsynapse assembly
S	0000166	molecular_function	nucleotide binding
S	0000786	cellular_component	nucleosome
S	0001738	biological_process	morphogenesis of a polarized epithelium
S	0005515	molecular_function	protein binding
S	0005524	molecular_function	ATP binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005884	cellular_component	actin filament
S	0005886	cellular_component	plasma membrane
S	0005903	cellular_component	brush border
S	0005911	cellular_component	cell-cell junction
S	0005912	cellular_component	adherens junction
S	0005925	cellular_component	focal adhesion
S	0007163	biological_process	establishment or maintenance of cell polarity
S	0007409	biological_process	axonogenesis
S	0015629	cellular_component	actin cytoskeleton
S	0016020	cellular_component	membrane
S	0016787	molecular_function	hydrolase activity
S	0016887	molecular_function	ATP hydrolysis activity
S	0019894	molecular_function	kinesin binding
S	0019901	molecular_function	protein kinase binding
S	0030027	cellular_component	lamellipodium
S	0030235	molecular_function	nitric-oxide synthase regulator activity
S	0030424	cellular_component	axon
S	0030863	cellular_component	cortical cytoskeleton
S	0030957	molecular_function	Tat protein binding
S	0032991	cellular_component	protein-containing complex
S	0034333	biological_process	adherens junction assembly
S	0035267	cellular_component	NuA4 histone acetyltransferase complex
S	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
S	0042802	molecular_function	identical protein binding
S	0043296	cellular_component	apical junction complex
S	0044305	cellular_component	calyx of Held
S	0045176	biological_process	apical protein localization
S	0045202	cellular_component	synapse
S	0048870	biological_process	cell motility
S	0050998	molecular_function	nitric-oxide synthase binding
S	0051621	biological_process	regulation of norepinephrine uptake
S	0051726	biological_process	regulation of cell cycle
S	0070160	cellular_component	tight junction
S	0071896	biological_process	protein localization to adherens junction
S	0072749	biological_process	cellular response to cytochalasin B
S	0097433	cellular_component	dense body
S	0098685	cellular_component	Schaffer collateral - CA1 synapse
S	0098871	cellular_component	postsynaptic actin cytoskeleton
S	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
S	0098974	biological_process	postsynaptic actin cytoskeleton organization
S	0098978	cellular_component	glutamatergic synapse
S	0141108	molecular_function	transporter regulator activity
S	0150111	biological_process	regulation of transepithelial transport
S	1900242	biological_process	regulation of synaptic vesicle endocytosis
S	1903076	biological_process	regulation of protein localization to plasma membrane
S	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
S	1990904	cellular_component	ribonucleoprotein complex
T	0000166	molecular_function	nucleotide binding
T	0000786	cellular_component	nucleosome
T	0001738	biological_process	morphogenesis of a polarized epithelium
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005884	cellular_component	actin filament
T	0005886	cellular_component	plasma membrane
T	0005903	cellular_component	brush border
T	0005911	cellular_component	cell-cell junction
T	0005912	cellular_component	adherens junction
T	0005925	cellular_component	focal adhesion
T	0007163	biological_process	establishment or maintenance of cell polarity
T	0007409	biological_process	axonogenesis
T	0015629	cellular_component	actin cytoskeleton
T	0016020	cellular_component	membrane
T	0016787	molecular_function	hydrolase activity
T	0016887	molecular_function	ATP hydrolysis activity
T	0019894	molecular_function	kinesin binding
T	0019901	molecular_function	protein kinase binding
T	0030027	cellular_component	lamellipodium
T	0030235	molecular_function	nitric-oxide synthase regulator activity
T	0030424	cellular_component	axon
T	0030863	cellular_component	cortical cytoskeleton
T	0030957	molecular_function	Tat protein binding
T	0032991	cellular_component	protein-containing complex
T	0034333	biological_process	adherens junction assembly
T	0035267	cellular_component	NuA4 histone acetyltransferase complex
T	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
T	0042802	molecular_function	identical protein binding
T	0043296	cellular_component	apical junction complex
T	0044305	cellular_component	calyx of Held
T	0045176	biological_process	apical protein localization
T	0045202	cellular_component	synapse
T	0048870	biological_process	cell motility
T	0050998	molecular_function	nitric-oxide synthase binding
T	0051621	biological_process	regulation of norepinephrine uptake
T	0051726	biological_process	regulation of cell cycle
T	0070160	cellular_component	tight junction
T	0071896	biological_process	protein localization to adherens junction
T	0072749	biological_process	cellular response to cytochalasin B
T	0097433	cellular_component	dense body
T	0098685	cellular_component	Schaffer collateral - CA1 synapse
T	0098871	cellular_component	postsynaptic actin cytoskeleton
T	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
T	0098974	biological_process	postsynaptic actin cytoskeleton organization
T	0098978	cellular_component	glutamatergic synapse
T	0141108	molecular_function	transporter regulator activity
T	0150111	biological_process	regulation of transepithelial transport
T	1900242	biological_process	regulation of synaptic vesicle endocytosis
T	1903076	biological_process	regulation of protein localization to plasma membrane
T	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
T	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
I	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
I	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPpMNPtkNR

Chain	Residue	Details
B	LEU108-ARG120
A	LEU111-ARG123
I	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A7MB62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	78
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	82
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	76
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	86
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---