Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9HZG

Ku70/80 bound to WRN-exo

Functional Information from GO Data
ChainGOidnamespacecontents
A0000723biological_processtelomere maintenance
A0000725biological_processrecombinational repair
A0000781cellular_componentchromosome, telomeric region
A0000783cellular_componentnuclear telomere cap complex
A0000976molecular_functiontranscription cis-regulatory region binding
A0002218biological_processactivation of innate immune response
A0002376biological_processimmune system process
A0002684biological_processpositive regulation of immune system process
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003690molecular_functiondouble-stranded DNA binding
A0003691molecular_functiondouble-stranded telomeric DNA binding
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0008094molecular_functionATP-dependent activity, acting on DNA
A0010212biological_processresponse to ionizing radiation
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0030332molecular_functioncyclin binding
A0032991cellular_componentprotein-containing complex
A0032993cellular_componentprotein-DNA complex
A0034774cellular_componentsecretory granule lumen
A0042162molecular_functiontelomeric repeat DNA binding
A0043138molecular_function3'-5' DNA helicase activity
A0043564cellular_componentKu70:Ku80 complex
A0044877molecular_functionprotein-containing complex binding
A0045027molecular_functionDNA end binding
A0045621biological_processpositive regulation of lymphocyte differentiation
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048660biological_processregulation of smooth muscle cell proliferation
A0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
A0070418cellular_componentDNA-dependent protein kinase complex
A0070419cellular_componentnonhomologous end joining complex
A0071475biological_processcellular hyperosmotic salinity response
A0071480biological_processcellular response to gamma radiation
A0071481biological_processcellular response to X-ray
A0097110molecular_functionscaffold protein binding
A0097680biological_processdouble-strand break repair via classical nonhomologous end joining
A0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
A1904813cellular_componentficolin-1-rich granule lumen
B0000723biological_processtelomere maintenance
B0000725biological_processrecombinational repair
B0000781cellular_componentchromosome, telomeric region
B0000783cellular_componentnuclear telomere cap complex
B0000976molecular_functiontranscription cis-regulatory region binding
B0002218biological_processactivation of innate immune response
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003690molecular_functiondouble-stranded DNA binding
B0003691molecular_functiondouble-stranded telomeric DNA binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
B0006302biological_processdouble-strand break repair
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006310biological_processDNA recombination
B0006974biological_processDNA damage response
B0007004biological_processtelomere maintenance via telomerase
B0008047molecular_functionenzyme activator activity
B0008094molecular_functionATP-dependent activity, acting on DNA
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0031625molecular_functionubiquitin protein ligase binding
B0032040cellular_componentsmall-subunit processome
B0032204biological_processregulation of telomere maintenance
B0032991cellular_componentprotein-containing complex
B0032993cellular_componentprotein-DNA complex
B0034462biological_processsmall-subunit processome assembly
B0034511molecular_functionU3 snoRNA binding
B0034774cellular_componentsecretory granule lumen
B0042162molecular_functiontelomeric repeat DNA binding
B0043138molecular_function3'-5' DNA helicase activity
B0043564cellular_componentKu70:Ku80 complex
B0044877molecular_functionprotein-containing complex binding
B0045027molecular_functionDNA end binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0048660biological_processregulation of smooth muscle cell proliferation
B0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
B0070198biological_processprotein localization to chromosome, telomeric region
B0070418cellular_componentDNA-dependent protein kinase complex
B0070419cellular_componentnonhomologous end joining complex
B0071480biological_processcellular response to gamma radiation
B0090734cellular_componentsite of DNA damage
B0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1904430biological_processnegative regulation of t-circle formation
B1990904cellular_componentribonucleoprotein complex
E0000287molecular_functionmagnesium ion binding
E0000400molecular_functionfour-way junction DNA binding
E0000403molecular_functionY-form DNA binding
E0000405molecular_functionbubble DNA binding
E0000723biological_processtelomere maintenance
E0000724biological_processdouble-strand break repair via homologous recombination
E0000731biological_processDNA synthesis involved in DNA repair
E0000781cellular_componentchromosome, telomeric region
E0003677molecular_functionDNA binding
E0003678molecular_functionDNA helicase activity
E0004386molecular_functionhelicase activity
E0004527molecular_functionexonuclease activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005657cellular_componentreplication fork
E0005694cellular_componentchromosome
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0006259biological_processDNA metabolic process
E0006260biological_processDNA replication
E0006281biological_processDNA repair
E0006284biological_processbase-excision repair
E0006298biological_processmismatch repair
E0006302biological_processdouble-strand break repair
E0006974biological_processDNA damage response
E0008408molecular_function3'-5' exonuclease activity
E0009267biological_processcellular response to starvation
E0009378molecular_functionfour-way junction helicase activity
E0010225biological_processresponse to UV-C
E0016607cellular_componentnuclear speck
E0016887molecular_functionATP hydrolysis activity
E0030145molecular_functionmanganese ion binding
E0031297biological_processreplication fork processing
E0032201biological_processtelomere maintenance via semi-conservative replication
E0032392biological_processDNA geometric change
E0032405molecular_functionMutLalpha complex binding
E0042803molecular_functionprotein homodimerization activity
E0043138molecular_function3'-5' DNA helicase activity
E0044877molecular_functionprotein-containing complex binding
E0051880molecular_functionG-quadruplex DNA binding
E0061749molecular_functionforked DNA-dependent helicase activity
E0061820biological_processtelomeric D-loop disassembly
E0061821molecular_functiontelomeric D-loop binding
E0061849molecular_functiontelomeric G-quadruplex DNA binding
E0070337molecular_function3'-flap-structured DNA binding
E0071480biological_processcellular response to gamma radiation
E0090398biological_processcellular senescence
E0090656biological_processt-circle formation
E0098530biological_processpositive regulation of strand invasion
E0140097molecular_functioncatalytic activity, acting on DNA
E1902570biological_processprotein localization to nucleolus
E1905773molecular_function8-hydroxy-2'-deoxyguanosine DNA binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues207
DetailsDomain: {"description":"Ku"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues34
DetailsDomain: {"description":"SAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00186","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues64
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues109
DetailsRegion: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues5
DetailsRegion: {"description":"Interaction with BAX","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues5
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"35545041","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues9
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16622405","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FC0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsSite: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"20159463","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues199
DetailsDomain: {"description":"Ku","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues27
DetailsRegion: {"description":"Leucine-zipper"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

256448

PDB entries from 2026-07-15

PDB statisticsPDBj update infoContact PDBjnumon