9HHQ
Human monocarboxylate transporter 10
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003333 | biological_process | amino acid transmembrane transport |
| A | 0005302 | molecular_function | L-tyrosine transmembrane transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006590 | biological_process | thyroid hormone generation |
| A | 0006865 | biological_process | amino acid transport |
| A | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| A | 0015173 | molecular_function | aromatic amino acid transmembrane transporter activity |
| A | 0015192 | molecular_function | L-phenylalanine transmembrane transporter activity |
| A | 0015196 | molecular_function | L-tryptophan transmembrane transporter activity |
| A | 0015349 | molecular_function | thyroid hormone transmembrane transporter activity |
| A | 0015801 | biological_process | aromatic amino acid transport |
| A | 0015823 | biological_process | phenylalanine transport |
| A | 0015827 | biological_process | tryptophan transport |
| A | 0015828 | biological_process | tyrosine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030054 | cellular_component | cell junction |
| A | 0046943 | molecular_function | carboxylic acid transmembrane transporter activity |
| A | 0070327 | biological_process | thyroid hormone transport |
| A | 0070460 | biological_process | thyroid-stimulating hormone secretion |
| A | 1905039 | biological_process | carboxylic acid transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 165 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-GLU66 | |
| A | THR136-THR144 | |
| A | HIS193-GLY200 | |
| A | THR250-THR291 | |
| A | ASP351 | |
| A | GLN418-ALA419 | |
| A | HIS473-ILE515 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY67-ILE87 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 86 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | GLN88-THR114 | |
| A | GLU166-THR171 | |
| A | ARG222-VAL228 | |
| A | HIS313-GLU329 | |
| A | SER373-ASP396 | |
| A | LEU441-ALA451 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA115-PHE135 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA145-ILE165 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR172-GLY192 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU201-LEU221 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY229-PHE249 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA292-VAL312 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL330-ALA350 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR352-MET372 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY397-SER417 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE420-LEU440 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE452-ILE472 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91Y77 |
| Chain | Residue | Details |
| A | SER263 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER498 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER501 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q3U9N9 |
| Chain | Residue | Details |
| A | SER503 | |
| A | SER504 |
