9HFR

Cryo-EM structure of human CDADC1 inactive mutant (E400A): hexamer without a ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004126	molecular_function	cytidine deaminase activity
A	0004132	molecular_function	dCMP deaminase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006229	biological_process	dUTP biosynthetic process
A	0008270	molecular_function	zinc ion binding
A	0008829	molecular_function	dCTP deaminase activity
A	0042803	molecular_function	protein homodimerization activity
A	0061676	molecular_function	importin-alpha family protein binding
A	0070207	biological_process	protein homotrimerization
A	0070383	biological_process	DNA cytosine deamination
B	0004126	molecular_function	cytidine deaminase activity
B	0004132	molecular_function	dCMP deaminase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006229	biological_process	dUTP biosynthetic process
B	0008270	molecular_function	zinc ion binding
B	0008829	molecular_function	dCTP deaminase activity
B	0042803	molecular_function	protein homodimerization activity
B	0061676	molecular_function	importin-alpha family protein binding
B	0070207	biological_process	protein homotrimerization
B	0070383	biological_process	DNA cytosine deamination
C	0004126	molecular_function	cytidine deaminase activity
C	0004132	molecular_function	dCMP deaminase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006229	biological_process	dUTP biosynthetic process
C	0008270	molecular_function	zinc ion binding
C	0008829	molecular_function	dCTP deaminase activity
C	0042803	molecular_function	protein homodimerization activity
C	0061676	molecular_function	importin-alpha family protein binding
C	0070207	biological_process	protein homotrimerization
C	0070383	biological_process	DNA cytosine deamination
D	0004126	molecular_function	cytidine deaminase activity
D	0004132	molecular_function	dCMP deaminase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006229	biological_process	dUTP biosynthetic process
D	0008270	molecular_function	zinc ion binding
D	0008829	molecular_function	dCTP deaminase activity
D	0042803	molecular_function	protein homodimerization activity
D	0061676	molecular_function	importin-alpha family protein binding
D	0070207	biological_process	protein homotrimerization
D	0070383	biological_process	DNA cytosine deamination
E	0004126	molecular_function	cytidine deaminase activity
E	0004132	molecular_function	dCMP deaminase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006229	biological_process	dUTP biosynthetic process
E	0008270	molecular_function	zinc ion binding
E	0008829	molecular_function	dCTP deaminase activity
E	0042803	molecular_function	protein homodimerization activity
E	0061676	molecular_function	importin-alpha family protein binding
E	0070207	biological_process	protein homotrimerization
E	0070383	biological_process	DNA cytosine deamination
F	0004126	molecular_function	cytidine deaminase activity
F	0004132	molecular_function	dCMP deaminase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006229	biological_process	dUTP biosynthetic process
F	0008270	molecular_function	zinc ion binding
F	0008829	molecular_function	dCTP deaminase activity
F	0042803	molecular_function	protein homodimerization activity
F	0061676	molecular_function	importin-alpha family protein binding
F	0070207	biological_process	protein homotrimerization
F	0070383	biological_process	DNA cytosine deamination

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Motif: {"description":"Nuclear export signal","evidences":[{"source":"PubMed","id":"26945630","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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