9HEQ
Open-state RyR1 in 0.01% POPC micelles, in complex with a nanobody and FKBP12
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 908 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 168 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 64 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 76 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 220 |
| Details | Domain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 180 |
| Details | Domain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 216 |
| Details | Domain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 864 |
| Details | Domain: {"description":"B30.2/SPRY 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00548","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 452 |
| Details | Repeat: {"description":"1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 112 |
| Details | Domain: {"description":"EF-hand","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 44 |
| Details | Region: {"description":"Interaction with FKBP1A","evidences":[{"source":"PubMed","id":"26245150","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 24 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5T9V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"F1LMY4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P21817","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P21817","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 352 |
| Details | Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
