9H60

Leishmania braziliensis ISP2 in complex with bovine alpha-chymotrypsin

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0097180	cellular_component	serine protease inhibitor complex
B	0097655	molecular_function	serpin family protein binding
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0006508	biological_process	proteolysis
D	0097180	cellular_component	serine protease inhibitor complex
D	0097655	molecular_function	serpin family protein binding

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
B	VAL53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. SScmGDSGGPLV

Chain	Residue	Details
B	SER189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 387

Chain	Residue	Details
B	HIS57	electrostatic stabiliser, proton shuttle (general acid/base)
B	ASP102	modifies pKa
B	GLY193	electrostatic stabiliser
B	SER195	covalent catalysis
B	GLY196	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	5
Details	M-CSA 387

Chain	Residue	Details
D	HIS57	electrostatic stabiliser, proton shuttle (general acid/base)
D	ASP102	modifies pKa
D	GLY193	electrostatic stabiliser
D	SER195	covalent catalysis
D	GLY196	electrostatic stabiliser

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