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9H5K

Cryo-EM structure of the SEAC-EGOC supercomplex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
a0000166molecular_functionnucleotide binding
a0000329cellular_componentfungal-type vacuole membrane
a0000781cellular_componentchromosome, telomeric region
a0003924molecular_functionGTPase activity
a0005515molecular_functionprotein binding
a0005525molecular_functionGTP binding
a0005634cellular_componentnucleus
a0005737cellular_componentcytoplasm
a0005770cellular_componentlate endosome
a0005774cellular_componentvacuolar membrane
a0006360biological_processtranscription by RNA polymerase I
a0006383biological_processtranscription by RNA polymerase III
a0006817biological_processphosphate ion transport
a0006995biological_processcellular response to nitrogen starvation
a0009267biological_processcellular response to starvation
a0010507biological_processnegative regulation of autophagy
a0016237biological_processmicroautophagy
a0016787molecular_functionhydrolase activity
a0031509biological_processsubtelomeric heterochromatin formation
a0031902cellular_componentlate endosome membrane
a0032008biological_processpositive regulation of TOR signaling
a0032456biological_processendocytic recycling
a0034599biological_processcellular response to oxidative stress
a0042802molecular_functionidentical protein binding
a0071230biological_processcellular response to amino acid stimulus
a0071986cellular_componentRagulator complex
a1903778biological_processprotein localization to vacuolar membrane
a1904263biological_processpositive regulation of TORC1 signaling
a1990131cellular_componentGtr1-Gtr2 GTPase complex
A0000324cellular_componentfungal-type vacuole
A0005774cellular_componentvacuolar membrane
A0005829cellular_componentcytosol
A0008270molecular_functionzinc ion binding
A0015031biological_processprotein transport
A0016239biological_processpositive regulation of macroautophagy
A0035859cellular_componentSeh1-associated complex
A0046872molecular_functionmetal ion binding
A0061700cellular_componentGATOR2 complex
A1903432biological_processregulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
b0000166molecular_functionnucleotide binding
b0000329cellular_componentfungal-type vacuole membrane
b0000781cellular_componentchromosome, telomeric region
b0003924molecular_functionGTPase activity
b0005515molecular_functionprotein binding
b0005525molecular_functionGTP binding
b0005634cellular_componentnucleus
b0005737cellular_componentcytoplasm
b0005770cellular_componentlate endosome
b0005774cellular_componentvacuolar membrane
b0006360biological_processtranscription by RNA polymerase I
b0006383biological_processtranscription by RNA polymerase III
b0006817biological_processphosphate ion transport
b0006995biological_processcellular response to nitrogen starvation
b0009267biological_processcellular response to starvation
b0010507biological_processnegative regulation of autophagy
b0016237biological_processmicroautophagy
b0016787molecular_functionhydrolase activity
b0031509biological_processsubtelomeric heterochromatin formation
b0031902cellular_componentlate endosome membrane
b0032008biological_processpositive regulation of TOR signaling
b0032456biological_processendocytic recycling
b0034599biological_processcellular response to oxidative stress
b0042802molecular_functionidentical protein binding
b0071230biological_processcellular response to amino acid stimulus
b0071986cellular_componentRagulator complex
b1903778biological_processprotein localization to vacuolar membrane
b1904263biological_processpositive regulation of TORC1 signaling
b1990131cellular_componentGtr1-Gtr2 GTPase complex
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005774cellular_componentvacuolar membrane
B0008270molecular_functionzinc ion binding
B0015031biological_processprotein transport
B0035859cellular_componentSeh1-associated complex
B1903432biological_processregulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
c0000166molecular_functionnucleotide binding
c0000329cellular_componentfungal-type vacuole membrane
c0000785cellular_componentchromatin
c0003924molecular_functionGTPase activity
c0005515molecular_functionprotein binding
c0005525molecular_functionGTP binding
c0005634cellular_componentnucleus
c0005737cellular_componentcytoplasm
c0005770cellular_componentlate endosome
c0005774cellular_componentvacuolar membrane
c0006995biological_processcellular response to nitrogen starvation
c0009267biological_processcellular response to starvation
c0010507biological_processnegative regulation of autophagy
c0016237biological_processmicroautophagy
c0016787molecular_functionhydrolase activity
c0031902cellular_componentlate endosome membrane
c0032008biological_processpositive regulation of TOR signaling
c0032456biological_processendocytic recycling
c0034599biological_processcellular response to oxidative stress
c0045121cellular_componentmembrane raft
c0045944biological_processpositive regulation of transcription by RNA polymerase II
c0071230biological_processcellular response to amino acid stimulus
c0071986cellular_componentRagulator complex
c1903778biological_processprotein localization to vacuolar membrane
c1904263biological_processpositive regulation of TORC1 signaling
c1990131cellular_componentGtr1-Gtr2 GTPase complex
C0000329cellular_componentfungal-type vacuole membrane
C0005515molecular_functionprotein binding
C0005774cellular_componentvacuolar membrane
C0008270molecular_functionzinc ion binding
C0015031biological_processprotein transport
C0034198biological_processcellular response to amino acid starvation
C0035591molecular_functionsignaling adaptor activity
C0035859cellular_componentSeh1-associated complex
C1903432biological_processregulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
d0000166molecular_functionnucleotide binding
d0000329cellular_componentfungal-type vacuole membrane
d0000785cellular_componentchromatin
d0003924molecular_functionGTPase activity
d0005515molecular_functionprotein binding
d0005525molecular_functionGTP binding
d0005634cellular_componentnucleus
d0005737cellular_componentcytoplasm
d0005770cellular_componentlate endosome
d0005774cellular_componentvacuolar membrane
d0006995biological_processcellular response to nitrogen starvation
d0009267biological_processcellular response to starvation
d0010507biological_processnegative regulation of autophagy
d0016237biological_processmicroautophagy
d0016787molecular_functionhydrolase activity
d0031902cellular_componentlate endosome membrane
d0032008biological_processpositive regulation of TOR signaling
d0032456biological_processendocytic recycling
d0034599biological_processcellular response to oxidative stress
d0045121cellular_componentmembrane raft
d0045944biological_processpositive regulation of transcription by RNA polymerase II
d0071230biological_processcellular response to amino acid stimulus
d0071986cellular_componentRagulator complex
d1903778biological_processprotein localization to vacuolar membrane
d1904263biological_processpositive regulation of TORC1 signaling
d1990131cellular_componentGtr1-Gtr2 GTPase complex
D0005515molecular_functionprotein binding
D0005635cellular_componentnuclear envelope
D0005643cellular_componentnuclear pore
D0005774cellular_componentvacuolar membrane
D0006913biological_processnucleocytoplasmic transport
D0015031biological_processprotein transport
D0017056molecular_functionstructural constituent of nuclear pore
D0031080cellular_componentnuclear pore outer ring
D0031965cellular_componentnuclear membrane
D0034198biological_processcellular response to amino acid starvation
D0035859cellular_componentSeh1-associated complex
D0051028biological_processmRNA transport
D1903432biological_processregulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
E0005515molecular_functionprotein binding
E0005635cellular_componentnuclear envelope
E0005643cellular_componentnuclear pore
E0005774cellular_componentvacuolar membrane
E0006913biological_processnucleocytoplasmic transport
E0015031biological_processprotein transport
E0017056molecular_functionstructural constituent of nuclear pore
E0031080cellular_componentnuclear pore outer ring
E0031965cellular_componentnuclear membrane
E0034198biological_processcellular response to amino acid starvation
E0035859cellular_componentSeh1-associated complex
E0051028biological_processmRNA transport
E1903432biological_processregulation of TORC1 signaling
E1904263biological_processpositive regulation of TORC1 signaling
F0005515molecular_functionprotein binding
F0005635cellular_componentnuclear envelope
F0005643cellular_componentnuclear pore
F0005774cellular_componentvacuolar membrane
F0006913biological_processnucleocytoplasmic transport
F0015031biological_processprotein transport
F0017056molecular_functionstructural constituent of nuclear pore
F0031080cellular_componentnuclear pore outer ring
F0031965cellular_componentnuclear membrane
F0034198biological_processcellular response to amino acid starvation
F0035859cellular_componentSeh1-associated complex
F0051028biological_processmRNA transport
F1903432biological_processregulation of TORC1 signaling
F1904263biological_processpositive regulation of TORC1 signaling
g0003674molecular_functionmolecular_function
g0005096molecular_functionGTPase activator activity
g0005515molecular_functionprotein binding
g0005774cellular_componentvacuolar membrane
g0006351biological_processDNA-templated transcription
g0006995biological_processcellular response to nitrogen starvation
g0009410biological_processresponse to xenobiotic stimulus
g0010508biological_processpositive regulation of autophagy
g0015031biological_processprotein transport
g0015824biological_processproline transport
g0015840biological_processurea transport
g0034198biological_processcellular response to amino acid starvation
g0035859cellular_componentSeh1-associated complex
g1903432biological_processregulation of TORC1 signaling
g1904262biological_processnegative regulation of TORC1 signaling
g1990130cellular_componentGATOR1 complex
g2000785biological_processregulation of autophagosome assembly
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005774cellular_componentvacuolar membrane
G0008270molecular_functionzinc ion binding
G0015031biological_processprotein transport
G0035859cellular_componentSeh1-associated complex
G1903432biological_processregulation of TORC1 signaling
G1904263biological_processpositive regulation of TORC1 signaling
H0005198molecular_functionstructural molecule activity
H0005515molecular_functionprotein binding
H0005635cellular_componentnuclear envelope
H0005643cellular_componentnuclear pore
H0005774cellular_componentvacuolar membrane
H0005783cellular_componentendoplasmic reticulum
H0005789cellular_componentendoplasmic reticulum membrane
H0006606biological_processprotein import into nucleus
H0006913biological_processnucleocytoplasmic transport
H0012507cellular_componentER to Golgi transport vesicle membrane
H0015031biological_processprotein transport
H0016192biological_processvesicle-mediated transport
H0030127cellular_componentCOPII vesicle coat
H0031080cellular_componentnuclear pore outer ring
H0031410cellular_componentcytoplasmic vesicle
H0032008biological_processpositive regulation of TOR signaling
H0032527biological_processprotein exit from endoplasmic reticulum
H0035859cellular_componentSeh1-associated complex
H0036503biological_processERAD pathway
H0045893biological_processpositive regulation of DNA-templated transcription
H0051028biological_processmRNA transport
H0051664biological_processnuclear pore localization
H0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
H0070971cellular_componentendoplasmic reticulum exit site
H0071944cellular_componentcell periphery
H0090114biological_processCOPII-coated vesicle budding
H1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
H1903432biological_processregulation of TORC1 signaling
H1904263biological_processpositive regulation of TORC1 signaling
I0000324cellular_componentfungal-type vacuole
I0005774cellular_componentvacuolar membrane
I0005829cellular_componentcytosol
I0008270molecular_functionzinc ion binding
I0015031biological_processprotein transport
I0016239biological_processpositive regulation of macroautophagy
I0035859cellular_componentSeh1-associated complex
I0046872molecular_functionmetal ion binding
I0061700cellular_componentGATOR2 complex
I1903432biological_processregulation of TORC1 signaling
I1904263biological_processpositive regulation of TORC1 signaling
j0000329cellular_componentfungal-type vacuole membrane
j0005096molecular_functionGTPase activator activity
j0005515molecular_functionprotein binding
j0005774cellular_componentvacuolar membrane
j0006995biological_processcellular response to nitrogen starvation
j0010508biological_processpositive regulation of autophagy
j0015031biological_processprotein transport
j0030695molecular_functionGTPase regulator activity
j0032007biological_processnegative regulation of TOR signaling
j0034599biological_processcellular response to oxidative stress
j0035859cellular_componentSeh1-associated complex
j0051058biological_processnegative regulation of small GTPase mediated signal transduction
j1903432biological_processregulation of TORC1 signaling
j1904262biological_processnegative regulation of TORC1 signaling
j1990130cellular_componentGATOR1 complex
j2000785biological_processregulation of autophagosome assembly
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005774cellular_componentvacuolar membrane
J0008270molecular_functionzinc ion binding
J0015031biological_processprotein transport
J0035859cellular_componentSeh1-associated complex
J1903432biological_processregulation of TORC1 signaling
J1904263biological_processpositive regulation of TORC1 signaling
K0000329cellular_componentfungal-type vacuole membrane
K0005515molecular_functionprotein binding
K0005774cellular_componentvacuolar membrane
K0008270molecular_functionzinc ion binding
K0015031biological_processprotein transport
K0034198biological_processcellular response to amino acid starvation
K0035591molecular_functionsignaling adaptor activity
K0035859cellular_componentSeh1-associated complex
K1903432biological_processregulation of TORC1 signaling
K1904263biological_processpositive regulation of TORC1 signaling
L0005515molecular_functionprotein binding
L0005635cellular_componentnuclear envelope
L0005643cellular_componentnuclear pore
L0005774cellular_componentvacuolar membrane
L0006913biological_processnucleocytoplasmic transport
L0015031biological_processprotein transport
L0017056molecular_functionstructural constituent of nuclear pore
L0031080cellular_componentnuclear pore outer ring
L0031965cellular_componentnuclear membrane
L0034198biological_processcellular response to amino acid starvation
L0035859cellular_componentSeh1-associated complex
L0051028biological_processmRNA transport
L1903432biological_processregulation of TORC1 signaling
L1904263biological_processpositive regulation of TORC1 signaling
M0005515molecular_functionprotein binding
M0005635cellular_componentnuclear envelope
M0005643cellular_componentnuclear pore
M0005774cellular_componentvacuolar membrane
M0006913biological_processnucleocytoplasmic transport
M0015031biological_processprotein transport
M0017056molecular_functionstructural constituent of nuclear pore
M0031080cellular_componentnuclear pore outer ring
M0031965cellular_componentnuclear membrane
M0034198biological_processcellular response to amino acid starvation
M0035859cellular_componentSeh1-associated complex
M0051028biological_processmRNA transport
M1903432biological_processregulation of TORC1 signaling
M1904263biological_processpositive regulation of TORC1 signaling
N0005515molecular_functionprotein binding
N0005635cellular_componentnuclear envelope
N0005643cellular_componentnuclear pore
N0005774cellular_componentvacuolar membrane
N0006913biological_processnucleocytoplasmic transport
N0015031biological_processprotein transport
N0017056molecular_functionstructural constituent of nuclear pore
N0031080cellular_componentnuclear pore outer ring
N0031965cellular_componentnuclear membrane
N0034198biological_processcellular response to amino acid starvation
N0035859cellular_componentSeh1-associated complex
N0051028biological_processmRNA transport
N1903432biological_processregulation of TORC1 signaling
N1904263biological_processpositive regulation of TORC1 signaling
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005774cellular_componentvacuolar membrane
O0008270molecular_functionzinc ion binding
O0015031biological_processprotein transport
O0035859cellular_componentSeh1-associated complex
O1903432biological_processregulation of TORC1 signaling
O1904263biological_processpositive regulation of TORC1 signaling
P0005198molecular_functionstructural molecule activity
P0005515molecular_functionprotein binding
P0005635cellular_componentnuclear envelope
P0005643cellular_componentnuclear pore
P0005774cellular_componentvacuolar membrane
P0005783cellular_componentendoplasmic reticulum
P0005789cellular_componentendoplasmic reticulum membrane
P0006606biological_processprotein import into nucleus
P0006913biological_processnucleocytoplasmic transport
P0012507cellular_componentER to Golgi transport vesicle membrane
P0015031biological_processprotein transport
P0016192biological_processvesicle-mediated transport
P0030127cellular_componentCOPII vesicle coat
P0031080cellular_componentnuclear pore outer ring
P0031410cellular_componentcytoplasmic vesicle
P0032008biological_processpositive regulation of TOR signaling
P0032527biological_processprotein exit from endoplasmic reticulum
P0035859cellular_componentSeh1-associated complex
P0036503biological_processERAD pathway
P0045893biological_processpositive regulation of DNA-templated transcription
P0051028biological_processmRNA transport
P0051664biological_processnuclear pore localization
P0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
P0070971cellular_componentendoplasmic reticulum exit site
P0071944cellular_componentcell periphery
P0090114biological_processCOPII-coated vesicle budding
P1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
P1903432biological_processregulation of TORC1 signaling
P1904263biological_processpositive regulation of TORC1 signaling
R0000329cellular_componentfungal-type vacuole membrane
R0003674molecular_functionmolecular_function
R0005515molecular_functionprotein binding
R0005770cellular_componentlate endosome
R0005774cellular_componentvacuolar membrane
R0005829cellular_componentcytosol
R0006914biological_processautophagy
R0007035biological_processvacuolar acidification
R0015031biological_processprotein transport
R0016237biological_processmicroautophagy
R0031902cellular_componentlate endosome membrane
R0032008biological_processpositive regulation of TOR signaling
R0032456biological_processendocytic recycling
R0071986cellular_componentRagulator complex
R0072665biological_processprotein localization to vacuole
S0000329cellular_componentfungal-type vacuole membrane
S0003674molecular_functionmolecular_function
S0005515molecular_functionprotein binding
S0005770cellular_componentlate endosome
S0005774cellular_componentvacuolar membrane
S0005829cellular_componentcytosol
S0006914biological_processautophagy
S0007035biological_processvacuolar acidification
S0015031biological_processprotein transport
S0016237biological_processmicroautophagy
S0031902cellular_componentlate endosome membrane
S0032008biological_processpositive regulation of TOR signaling
S0032456biological_processendocytic recycling
S0071986cellular_componentRagulator complex
S0072665biological_processprotein localization to vacuole
T0003674molecular_functionmolecular_function
T0005096molecular_functionGTPase activator activity
T0005515molecular_functionprotein binding
T0005774cellular_componentvacuolar membrane
T0006351biological_processDNA-templated transcription
T0006995biological_processcellular response to nitrogen starvation
T0009410biological_processresponse to xenobiotic stimulus
T0010508biological_processpositive regulation of autophagy
T0015031biological_processprotein transport
T0015824biological_processproline transport
T0015840biological_processurea transport
T0034198biological_processcellular response to amino acid starvation
T0035859cellular_componentSeh1-associated complex
T1903432biological_processregulation of TORC1 signaling
T1904262biological_processnegative regulation of TORC1 signaling
T1990130cellular_componentGATOR1 complex
T2000785biological_processregulation of autophagosome assembly
U0000329cellular_componentfungal-type vacuole membrane
U0003674molecular_functionmolecular_function
U0016237biological_processmicroautophagy
U0032008biological_processpositive regulation of TOR signaling
U0038202biological_processTORC1 signaling
U0071986cellular_componentRagulator complex
U0072665biological_processprotein localization to vacuole
W0000329cellular_componentfungal-type vacuole membrane
W0003674molecular_functionmolecular_function
W0016237biological_processmicroautophagy
W0032008biological_processpositive regulation of TOR signaling
W0038202biological_processTORC1 signaling
W0071986cellular_componentRagulator complex
W0072665biological_processprotein localization to vacuole
X0000329cellular_componentfungal-type vacuole membrane
X0005096molecular_functionGTPase activator activity
X0005515molecular_functionprotein binding
X0005774cellular_componentvacuolar membrane
X0006995biological_processcellular response to nitrogen starvation
X0010508biological_processpositive regulation of autophagy
X0015031biological_processprotein transport
X0030695molecular_functionGTPase regulator activity
X0032007biological_processnegative regulation of TOR signaling
X0034599biological_processcellular response to oxidative stress
X0035859cellular_componentSeh1-associated complex
X0051058biological_processnegative regulation of small GTPase mediated signal transduction
X1903432biological_processregulation of TORC1 signaling
X1904262biological_processnegative regulation of TORC1 signaling
X1990130cellular_componentGATOR1 complex
X2000785biological_processregulation of autophagosome assembly
Y0000329cellular_componentfungal-type vacuole membrane
Y0003674molecular_functionmolecular_function
Y0005515molecular_functionprotein binding
Y0005737cellular_componentcytoplasm
Y0005770cellular_componentlate endosome
Y0005774cellular_componentvacuolar membrane
Y0006914biological_processautophagy
Y0007165biological_processsignal transduction
Y0015031biological_processprotein transport
Y0016237biological_processmicroautophagy
Y0031902cellular_componentlate endosome membrane
Y0032008biological_processpositive regulation of TOR signaling
Y0032456biological_processendocytic recycling
Y0042802molecular_functionidentical protein binding
Y0071986cellular_componentRagulator complex
Z0000329cellular_componentfungal-type vacuole membrane
Z0003674molecular_functionmolecular_function
Z0005515molecular_functionprotein binding
Z0005737cellular_componentcytoplasm
Z0005770cellular_componentlate endosome
Z0005774cellular_componentvacuolar membrane
Z0006914biological_processautophagy
Z0007165biological_processsignal transduction
Z0015031biological_processprotein transport
Z0016237biological_processmicroautophagy
Z0031902cellular_componentlate endosome membrane
Z0032008biological_processpositive regulation of TOR signaling
Z0032456biological_processendocytic recycling
Z0042802molecular_functionidentical protein binding
Z0071986cellular_componentRagulator complex
Functional Information from PROSITE/UniProt
site_idPS00092
Number of Residues7
DetailsN6_MTASE N-6 Adenine-specific DNA methylases signature. IIADPPW
ChainResidueDetails
AILE1153-TRP1159

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LATCsvDtYVHAWDM
ChainResidueDetails
CLEU130-MET144
AILE274-LEU288

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues398
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues576
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues324
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues314
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues182
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues222
DetailsDomain: {"description":"RWD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00179","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues388
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues80
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues78
DetailsRepeat: {"description":"WD 9"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues84
DetailsZinc finger: {"description":"RING-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues30
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21816923","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3R7W","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues34
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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