Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9H4Q

Cryo-EM structure of the SEAC wing - EGOC

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000166	molecular_function	nucleotide binding
a	0000329	cellular_component	fungal-type vacuole membrane
a	0000781	cellular_component	chromosome, telomeric region
a	0003924	molecular_function	GTPase activity
a	0005515	molecular_function	protein binding
a	0005525	molecular_function	GTP binding
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005770	cellular_component	late endosome
a	0005774	cellular_component	vacuolar membrane
a	0006360	biological_process	transcription by RNA polymerase I
a	0006383	biological_process	transcription by RNA polymerase III
a	0006817	biological_process	phosphate ion transport
a	0006995	biological_process	cellular response to nitrogen starvation
a	0009267	biological_process	cellular response to starvation
a	0010507	biological_process	negative regulation of autophagy
a	0016237	biological_process	microautophagy
a	0016787	molecular_function	hydrolase activity
a	0031509	biological_process	subtelomeric heterochromatin formation
a	0031902	cellular_component	late endosome membrane
a	0032008	biological_process	positive regulation of TOR signaling
a	0032456	biological_process	endocytic recycling
a	0034599	biological_process	cellular response to oxidative stress
a	0042802	molecular_function	identical protein binding
a	0071230	biological_process	cellular response to amino acid stimulus
a	0071986	cellular_component	Ragulator complex
a	1903778	biological_process	protein localization to vacuolar membrane
a	1904263	biological_process	positive regulation of TORC1 signaling
a	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
c	0000166	molecular_function	nucleotide binding
c	0000329	cellular_component	fungal-type vacuole membrane
c	0000785	cellular_component	chromatin
c	0003924	molecular_function	GTPase activity
c	0005515	molecular_function	protein binding
c	0005525	molecular_function	GTP binding
c	0005634	cellular_component	nucleus
c	0005737	cellular_component	cytoplasm
c	0005770	cellular_component	late endosome
c	0005774	cellular_component	vacuolar membrane
c	0006995	biological_process	cellular response to nitrogen starvation
c	0009267	biological_process	cellular response to starvation
c	0010507	biological_process	negative regulation of autophagy
c	0016237	biological_process	microautophagy
c	0016787	molecular_function	hydrolase activity
c	0031902	cellular_component	late endosome membrane
c	0032008	biological_process	positive regulation of TOR signaling
c	0032456	biological_process	endocytic recycling
c	0034599	biological_process	cellular response to oxidative stress
c	0045121	cellular_component	membrane raft
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0071230	biological_process	cellular response to amino acid stimulus
c	0071986	cellular_component	Ragulator complex
c	1903778	biological_process	protein localization to vacuolar membrane
c	1904263	biological_process	positive regulation of TORC1 signaling
c	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
C	0000329	cellular_component	fungal-type vacuole membrane
C	0005515	molecular_function	protein binding
C	0005774	cellular_component	vacuolar membrane
C	0008270	molecular_function	zinc ion binding
C	0015031	biological_process	protein transport
C	0034198	biological_process	cellular response to amino acid starvation
C	0035591	molecular_function	signaling adaptor activity
C	0035859	cellular_component	Seh1-associated complex
C	1903432	biological_process	regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
R	0000329	cellular_component	fungal-type vacuole membrane
R	0003674	molecular_function	molecular_function
R	0005515	molecular_function	protein binding
R	0005770	cellular_component	late endosome
R	0005774	cellular_component	vacuolar membrane
R	0005829	cellular_component	cytosol
R	0006914	biological_process	autophagy
R	0007035	biological_process	vacuolar acidification
R	0015031	biological_process	protein transport
R	0016237	biological_process	microautophagy
R	0031902	cellular_component	late endosome membrane
R	0032008	biological_process	positive regulation of TOR signaling
R	0032456	biological_process	endocytic recycling
R	0071986	cellular_component	Ragulator complex
R	0072665	biological_process	protein localization to vacuole
T	0003674	molecular_function	molecular_function
T	0005096	molecular_function	GTPase activator activity
T	0005515	molecular_function	protein binding
T	0005774	cellular_component	vacuolar membrane
T	0006351	biological_process	DNA-templated transcription
T	0006995	biological_process	cellular response to nitrogen starvation
T	0009410	biological_process	response to xenobiotic stimulus
T	0010508	biological_process	positive regulation of autophagy
T	0015031	biological_process	protein transport
T	0015824	biological_process	proline transport
T	0015840	biological_process	urea transport
T	0034198	biological_process	cellular response to amino acid starvation
T	0035859	cellular_component	Seh1-associated complex
T	1903432	biological_process	regulation of TORC1 signaling
T	1904262	biological_process	negative regulation of TORC1 signaling
T	1990130	cellular_component	GATOR1 complex
T	2000785	biological_process	regulation of autophagosome assembly
U	0000329	cellular_component	fungal-type vacuole membrane
U	0003674	molecular_function	molecular_function
U	0016237	biological_process	microautophagy
U	0032008	biological_process	positive regulation of TOR signaling
U	0038202	biological_process	TORC1 signaling
U	0071986	cellular_component	Ragulator complex
U	0072665	biological_process	protein localization to vacuole
X	0000329	cellular_component	fungal-type vacuole membrane
X	0005096	molecular_function	GTPase activator activity
X	0005515	molecular_function	protein binding
X	0005774	cellular_component	vacuolar membrane
X	0006995	biological_process	cellular response to nitrogen starvation
X	0010508	biological_process	positive regulation of autophagy
X	0015031	biological_process	protein transport
X	0030695	molecular_function	GTPase regulator activity
X	0032007	biological_process	negative regulation of TOR signaling
X	0034599	biological_process	cellular response to oxidative stress
X	0035859	cellular_component	Seh1-associated complex
X	0051058	biological_process	negative regulation of small GTPase mediated signal transduction
X	1903432	biological_process	regulation of TORC1 signaling
X	1904262	biological_process	negative regulation of TORC1 signaling
X	1990130	cellular_component	GATOR1 complex
X	2000785	biological_process	regulation of autophagosome assembly
Y	0000329	cellular_component	fungal-type vacuole membrane
Y	0003674	molecular_function	molecular_function
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005770	cellular_component	late endosome
Y	0005774	cellular_component	vacuolar membrane
Y	0006914	biological_process	autophagy
Y	0007165	biological_process	signal transduction
Y	0015031	biological_process	protein transport
Y	0016237	biological_process	microautophagy
Y	0031902	cellular_component	late endosome membrane
Y	0032008	biological_process	positive regulation of TOR signaling
Y	0032456	biological_process	endocytic recycling
Y	0042802	molecular_function	identical protein binding
Y	0071986	cellular_component	Ragulator complex

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATCsvDtYVHAWDM

Chain	Residue	Details
C	LEU130-MET144

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	43
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	40
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	49
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	111
Details	Domain: {"description":"RWD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00179","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21816923","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3R7W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	17
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)