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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9GW2

State 2 MAP 1 SETD2 bound to proximal H3 of upstream nucleosome

Functional Information from GO Data
ChainGOidnamespacecontents
a0000786cellular_componentnucleosome
a0003677molecular_functionDNA binding
a0005515molecular_functionprotein binding
a0005576cellular_componentextracellular region
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005694cellular_componentchromosome
a0006325biological_processchromatin organization
a0006334biological_processnucleosome assembly
a0030527molecular_functionstructural constituent of chromatin
a0031492molecular_functionnucleosomal DNA binding
a0031507biological_processheterochromatin formation
a0070062cellular_componentextracellular exosome
b0000781cellular_componentchromosome, telomeric region
b0000786cellular_componentnucleosome
b0003677molecular_functionDNA binding
b0003723molecular_functionRNA binding
b0005515molecular_functionprotein binding
b0005576cellular_componentextracellular region
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005694cellular_componentchromosome
b0006325biological_processchromatin organization
b0006334biological_processnucleosome assembly
b0016020cellular_componentmembrane
b0030527molecular_functionstructural constituent of chromatin
b0032200biological_processtelomere organization
b0032991cellular_componentprotein-containing complex
b0045653biological_processnegative regulation of megakaryocyte differentiation
b0061644biological_processprotein localization to CENP-A containing chromatin
b0070062cellular_componentextracellular exosome
c0000786cellular_componentnucleosome
c0003677molecular_functionDNA binding
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005694cellular_componentchromosome
c0006325biological_processchromatin organization
c0008285biological_processnegative regulation of cell population proliferation
c0030527molecular_functionstructural constituent of chromatin
c0031507biological_processheterochromatin formation
c0061644biological_processprotein localization to CENP-A containing chromatin
c0070062cellular_componentextracellular exosome
d0000786cellular_componentnucleosome
d0002227biological_processinnate immune response in mucosa
d0003677molecular_functionDNA binding
d0005515molecular_functionprotein binding
d0005615cellular_componentextracellular space
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005694cellular_componentchromosome
d0006325biological_processchromatin organization
d0019731biological_processantibacterial humoral response
d0030527molecular_functionstructural constituent of chromatin
d0031640biological_processkilling of cells of another organism
d0042742biological_processdefense response to bacterium
d0050829biological_processdefense response to Gram-negative bacterium
d0050830biological_processdefense response to Gram-positive bacterium
d0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
e0000786cellular_componentnucleosome
e0003677molecular_functionDNA binding
e0005515molecular_functionprotein binding
e0005576cellular_componentextracellular region
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005694cellular_componentchromosome
e0006325biological_processchromatin organization
e0006334biological_processnucleosome assembly
e0030527molecular_functionstructural constituent of chromatin
e0031492molecular_functionnucleosomal DNA binding
e0031507biological_processheterochromatin formation
e0070062cellular_componentextracellular exosome
f0000781cellular_componentchromosome, telomeric region
f0000786cellular_componentnucleosome
f0003677molecular_functionDNA binding
f0003723molecular_functionRNA binding
f0005515molecular_functionprotein binding
f0005576cellular_componentextracellular region
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005694cellular_componentchromosome
f0006325biological_processchromatin organization
f0006334biological_processnucleosome assembly
f0016020cellular_componentmembrane
f0030527molecular_functionstructural constituent of chromatin
f0032200biological_processtelomere organization
f0032991cellular_componentprotein-containing complex
f0045653biological_processnegative regulation of megakaryocyte differentiation
f0061644biological_processprotein localization to CENP-A containing chromatin
f0070062cellular_componentextracellular exosome
g0000786cellular_componentnucleosome
g0003677molecular_functionDNA binding
g0005515molecular_functionprotein binding
g0005634cellular_componentnucleus
g0005654cellular_componentnucleoplasm
g0005694cellular_componentchromosome
g0006325biological_processchromatin organization
g0008285biological_processnegative regulation of cell population proliferation
g0030527molecular_functionstructural constituent of chromatin
g0031507biological_processheterochromatin formation
g0061644biological_processprotein localization to CENP-A containing chromatin
g0070062cellular_componentextracellular exosome
h0000786cellular_componentnucleosome
h0002227biological_processinnate immune response in mucosa
h0003677molecular_functionDNA binding
h0005515molecular_functionprotein binding
h0005615cellular_componentextracellular space
h0005634cellular_componentnucleus
h0005654cellular_componentnucleoplasm
h0005694cellular_componentchromosome
h0006325biological_processchromatin organization
h0019731biological_processantibacterial humoral response
h0030527molecular_functionstructural constituent of chromatin
h0031640biological_processkilling of cells of another organism
h0042742biological_processdefense response to bacterium
h0050829biological_processdefense response to Gram-negative bacterium
h0050830biological_processdefense response to Gram-positive bacterium
h0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
j0003723molecular_functionRNA binding
j0005634cellular_componentnucleus
j0005654cellular_componentnucleoplasm
j0005694cellular_componentchromosome
j0006260biological_processDNA replication
j0006281biological_processDNA repair
j0006334biological_processnucleosome assembly
j0006337biological_processnucleosome disassembly
j0006351biological_processDNA-templated transcription
j0006366biological_processtranscription by RNA polymerase II
j0006974biological_processDNA damage response
j0008023cellular_componenttranscription elongation factor complex
j0031491molecular_functionnucleosome binding
j0032784biological_processregulation of DNA-templated transcription elongation
j0032786biological_processpositive regulation of DNA-templated transcription, elongation
j0035101cellular_componentFACT complex
Functional Information from PROSITE/UniProt
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
cALA22-VAL28
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
bGLY14-HIS18
site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
aLYS15-LEU21
site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
dARG92-GLY114
site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
aPRO67-ILE75
site_idPS01159
Number of Residues26
DetailsWW_DOMAIN_1 WW/rsp5/WWP domain signature. WktardpegkiyYYhvitrq.TQWDPP
ChainResidueDetails
OTRP2395-PRO2420
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues54
DetailsDomain: {"description":"AWS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00562","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues117
DetailsDomain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsDomain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23043551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27474439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28256625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V21","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V22","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23043551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27474439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28256625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V22","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19783980","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues15
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsModified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"21076176","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsModified residue: {"description":"N6-(beta-hydroxybutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"27105115","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsModified residue: {"description":"N6-crotonyllysine; alternate","evidences":[{"source":"PubMed","id":"21925322","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues4
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues2
DetailsModified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues2
DetailsModified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q8CGP1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues4
DetailsModified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues4
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues2
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues2
DetailsModified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues4
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI42
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI43
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI44
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI45
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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