9GU6

NCS-1 bound to FDA ligand 3

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005245	molecular_function	voltage-gated calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
B	0009966	biological_process	regulation of signal transduction
B	0010975	biological_process	regulation of neuron projection development
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070588	biological_process	calcium ion transmembrane transport
D	0005245	molecular_function	voltage-gated calcium channel activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
D	0009966	biological_process	regulation of signal transduction
D	0010975	biological_process	regulation of neuron projection development
D	0014069	cellular_component	postsynaptic density
D	0016020	cellular_component	membrane
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0070588	biological_process	calcium ion transmembrane transport
F	0005245	molecular_function	voltage-gated calcium channel activity
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
F	0009966	biological_process	regulation of signal transduction
F	0010975	biological_process	regulation of neuron projection development
F	0014069	cellular_component	postsynaptic density
F	0016020	cellular_component	membrane
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0046872	molecular_function	metal ion binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0070588	biological_process	calcium ion transmembrane transport
H	0005245	molecular_function	voltage-gated calcium channel activity
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
H	0009966	biological_process	regulation of signal transduction
H	0010975	biological_process	regulation of neuron projection development
H	0014069	cellular_component	postsynaptic density
H	0016020	cellular_component	membrane
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0046872	molecular_function	metal ion binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0070588	biological_process	calcium ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF

Chain	Residue	Details
B	ASP73-PHE85
B	ASP109-MET121
B	ASP157-PHE169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	140
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62168","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Region: {"description":"Interaction with IL1RAPL1","evidences":[{"source":"PubMed","id":"12783849","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---