9GSE

Cryo-EM structure of mouse PMCA-NPTN complex captured in E1 state without calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000902	biological_process	cell morphogenesis
A	0005215	molecular_function	transporter activity
A	0005388	molecular_function	P-type calcium transporter activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0007423	biological_process	sensory organ development
A	0007595	biological_process	lactation
A	0007605	biological_process	sensory perception of sound
A	0007626	biological_process	locomotory behavior
A	0008361	biological_process	regulation of cell size
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0021549	biological_process	cerebellum development
A	0021692	biological_process	cerebellar Purkinje cell layer morphogenesis
A	0021702	biological_process	cerebellar Purkinje cell differentiation
A	0021707	biological_process	cerebellar granule cell differentiation
A	0030165	molecular_function	PDZ domain binding
A	0030182	biological_process	neuron differentiation
A	0030425	cellular_component	dendrite
A	0030899	molecular_function	calcium-dependent ATPase activity
A	0032591	cellular_component	dendritic spine membrane
A	0032809	cellular_component	neuronal cell body membrane
A	0035254	molecular_function	glutamate receptor binding
A	0040011	biological_process	locomotion
A	0042428	biological_process	serotonin metabolic process
A	0042472	biological_process	inner ear morphogenesis
A	0042734	cellular_component	presynaptic membrane
A	0043025	cellular_component	neuronal cell body
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0045299	biological_process	otolith mineralization
A	0046068	biological_process	cGMP metabolic process
A	0048167	biological_process	regulation of synaptic plasticity
A	0048787	cellular_component	presynaptic active zone membrane
A	0048839	biological_process	inner ear development
A	0050808	biological_process	synapse organization
A	0050885	biological_process	neuromuscular process controlling balance
A	0050910	biological_process	detection of mechanical stimulus involved in sensory perception of sound
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0051928	biological_process	positive regulation of calcium ion transport
A	0060088	biological_process	auditory receptor cell stereocilium organization
A	0060113	biological_process	inner ear receptor cell differentiation
A	0070588	biological_process	calcium ion transmembrane transport
A	0090102	biological_process	cochlea development
A	0098684	cellular_component	photoreceptor ribbon synapse
A	0098688	cellular_component	parallel fiber to Purkinje cell synapse
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	0098982	cellular_component	GABA-ergic synapse
A	0099566	biological_process	regulation of postsynaptic cytosolic calcium ion concentration
A	1905059	molecular_function	P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	67
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	450
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	86
Details	Domain: {"description":"Ig-like 2","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	90
Details	Domain: {"description":"Ig-like 3","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	12
Details	Region: {"description":"Narpin; mediates binding with FGFR1 and has antidepressant-like activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19656770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19656770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16944957","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19656770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40836084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9GSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9GTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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