9GIK

Full-lenght Nedd4-2 E3 ubiquitin ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003254	biological_process	regulation of membrane depolarization
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005771	cellular_component	multivesicular body
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006811	biological_process	monoatomic ion transport
A	0007528	biological_process	neuromuscular junction development
A	0010766	biological_process	negative regulation of sodium ion transport
A	0016324	cellular_component	apical plasma membrane
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0017080	molecular_function	sodium channel regulator activity
A	0019870	molecular_function	potassium channel inhibitor activity
A	0019871	molecular_function	sodium channel inhibitor activity
A	0030154	biological_process	cell differentiation
A	0031175	biological_process	neuron projection development
A	0031623	biological_process	receptor internalization
A	0031647	biological_process	regulation of protein stability
A	0032801	biological_process	receptor catabolic process
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044325	molecular_function	transmembrane transporter binding
A	0045732	biological_process	positive regulation of protein catabolic process
A	0048814	biological_process	regulation of dendrite morphogenesis
A	0050807	biological_process	regulation of synapse organization
A	0060306	biological_process	regulation of membrane repolarization
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070062	cellular_component	extracellular exosome
A	0070936	biological_process	protein K48-linked ubiquitination
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	1901380	biological_process	negative regulation of potassium ion transmembrane transport
A	1902305	biological_process	regulation of sodium ion transmembrane transport
A	1902306	biological_process	negative regulation of sodium ion transmembrane transport
A	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
A	1903783	biological_process	negative regulation of sodium ion import across plasma membrane
A	1903861	biological_process	positive regulation of dendrite extension
A	2000009	biological_process	negative regulation of protein localization to cell surface
A	2001288	biological_process	positive regulation of caveolin-mediated endocytosis

Functional Information from PROSITE/UniProt

site_id	PS01159
Number of Residues	26
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. Weekvdnlgrt.YYvnhnnrtTQWHRP

Chain	Residue	Details
A	TRP199-PRO224
A	TRP371-PRO396
A	TRP483-PRO508
A	TRP534-PRO559

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Domain: {"description":"WW 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00224","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	33
Details	Domain: {"description":"WW 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00224","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00104","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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