9GCN
Co-crystal VHH (TPL1158_01_C09) - alpha-cobratoxin (Naja kaouthia)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| V | 0005576 | cellular_component | extracellular region |
| V | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| V | 0035821 | biological_process | modulation of process of another organism |
| V | 0090729 | molecular_function | toxin activity |
| V | 0099106 | molecular_function | ion channel regulator activity |
| X | 0005576 | cellular_component | extracellular region |
| X | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| X | 0035821 | biological_process | modulation of process of another organism |
| X | 0090729 | molecular_function | toxin activity |
| X | 0099106 | molecular_function | ion channel regulator activity |
| Y | 0005576 | cellular_component | extracellular region |
| Y | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| Y | 0035821 | biological_process | modulation of process of another organism |
| Y | 0090729 | molecular_function | toxin activity |
| Y | 0099106 | molecular_function | ion channel regulator activity |
| Z | 0005576 | cellular_component | extracellular region |
| Z | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| Z | 0035821 | biological_process | modulation of process of another organism |
| Z | 0090729 | molecular_function | toxin activity |
| Z | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PROSITE/UniProt
| site_id | PS00272 |
| Number of Residues | 21 |
| Details | SNAKE_TOXIN Snake toxins signature. GCaatCPtvktgvdiq.CCstD |
| Chain | Residue | Details |
| Y | GLY40-ASP60 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Site: {"description":"Binds to Torpedo AChR","evidences":[{"source":"PubMed","id":"10574958","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Site: {"description":"Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs","evidences":[{"source":"PubMed","id":"10574958","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10852927","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Site: {"description":"Binds to alpha-7/CHRNA7 AChR","evidences":[{"source":"PubMed","id":"10852927","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs, may be important for inhibition of GABA(A) receptors","evidences":[{"source":"PubMed","id":"10574958","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10852927","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26221036","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
