9GCL

Structure of the U11 snRNP C-lobe

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005689	cellular_component	U12-type spliceosomal complex
E	0006397	biological_process	mRNA processing
E	0008270	molecular_function	zinc ion binding
E	0008380	biological_process	RNA splicing
E	0034693	cellular_component	U11/U12 snRNP
E	0046872	molecular_function	metal ion binding
E	0071016	cellular_component	U12-type precatalytic spliceosome
F	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005689	cellular_component	U12-type spliceosomal complex
F	0005829	cellular_component	cytosol
F	0006397	biological_process	mRNA processing
F	0008270	molecular_function	zinc ion binding
F	0008380	biological_process	RNA splicing
F	0034693	cellular_component	U11/U12 snRNP
F	0046872	molecular_function	metal ion binding
F	0071016	cellular_component	U12-type precatalytic spliceosome
h	0000243	cellular_component	commitment complex
h	0000244	biological_process	spliceosomal tri-snRNP complex assembly
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005690	cellular_component	U4atac snRNP
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034693	cellular_component	U11/U12 snRNP
h	0034709	cellular_component	methylosome
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
h	0071001	cellular_component	U4/U6 snRNP
h	0071002	cellular_component	U4atac/U6atac snRNP
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071006	cellular_component	U2-type catalytic step 1 spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0071014	cellular_component	post-mRNA release spliceosomal complex
h	0071016	cellular_component	U12-type precatalytic spliceosome
h	0071018	cellular_component	U12-type catalytic step 2 spliceosome
h	0071020	cellular_component	post-spliceosomal complex
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990446	molecular_function	U1 snRNP binding
h	1990904	cellular_component	ribonucleoprotein complex
i	0000244	biological_process	spliceosomal tri-snRNP complex assembly
i	0000245	biological_process	spliceosomal complex assembly
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005684	cellular_component	U2-type spliceosomal complex
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005689	cellular_component	U12-type spliceosomal complex
i	0005690	cellular_component	U4atac snRNP
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034693	cellular_component	U11/U12 snRNP
i	0034709	cellular_component	methylosome
i	0034715	cellular_component	pICln-Sm protein complex
i	0034719	cellular_component	SMN-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
i	0070062	cellular_component	extracellular exosome
i	0071001	cellular_component	U4/U6 snRNP
i	0071002	cellular_component	U4atac/U6atac snRNP
i	0071005	cellular_component	U2-type precatalytic spliceosome
i	0071006	cellular_component	U2-type catalytic step 1 spliceosome
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
i	0071011	cellular_component	precatalytic spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0071014	cellular_component	post-mRNA release spliceosomal complex
i	0071016	cellular_component	U12-type precatalytic spliceosome
i	0071018	cellular_component	U12-type catalytic step 2 spliceosome
i	0071020	cellular_component	post-spliceosomal complex
i	0097525	cellular_component	spliceosomal snRNP complex
i	1903241	biological_process	U2-type prespliceosome assembly
i	1990904	cellular_component	ribonucleoprotein complex
j	0000243	cellular_component	commitment complex
j	0000244	biological_process	spliceosomal tri-snRNP complex assembly
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005683	cellular_component	U7 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005690	cellular_component	U4atac snRNP
j	0005697	cellular_component	telomerase holoenzyme complex
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006396	biological_process	RNA processing
j	0006397	biological_process	mRNA processing
j	0006479	biological_process	protein methylation
j	0008380	biological_process	RNA splicing
j	0016604	cellular_component	nuclear body
j	0019899	molecular_function	enzyme binding
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034693	cellular_component	U11/U12 snRNP
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
j	0070034	molecular_function	telomerase RNA binding
j	0071001	cellular_component	U4/U6 snRNP
j	0071002	cellular_component	U4atac/U6atac snRNP
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071006	cellular_component	U2-type catalytic step 1 spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0071014	cellular_component	post-mRNA release spliceosomal complex
j	0071016	cellular_component	U12-type precatalytic spliceosome
j	0071018	cellular_component	U12-type catalytic step 2 spliceosome
j	0071020	cellular_component	post-spliceosomal complex
j	0071045	biological_process	nuclear histone mRNA catabolic process
j	0071208	molecular_function	histone pre-mRNA DCP binding
j	0071209	molecular_function	U7 snRNA binding
j	0097526	cellular_component	spliceosomal tri-snRNP complex
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0000244	biological_process	spliceosomal tri-snRNP complex assembly
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005683	cellular_component	U7 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005690	cellular_component	U4atac snRNP
k	0005697	cellular_component	telomerase holoenzyme complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006397	biological_process	mRNA processing
k	0006479	biological_process	protein methylation
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034693	cellular_component	U11/U12 snRNP
k	0034709	cellular_component	methylosome
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
k	0070034	molecular_function	telomerase RNA binding
k	0070990	molecular_function	snRNP binding
k	0071001	cellular_component	U4/U6 snRNP
k	0071002	cellular_component	U4atac/U6atac snRNP
k	0071004	cellular_component	U2-type prespliceosome
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071006	cellular_component	U2-type catalytic step 1 spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0071014	cellular_component	post-mRNA release spliceosomal complex
k	0071016	cellular_component	U12-type precatalytic spliceosome
k	0071018	cellular_component	U12-type catalytic step 2 spliceosome
k	0071020	cellular_component	post-spliceosomal complex
k	0071045	biological_process	nuclear histone mRNA catabolic process
k	0071204	cellular_component	histone pre-mRNA 3'end processing complex
k	0071208	molecular_function	histone pre-mRNA DCP binding
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990446	molecular_function	U1 snRNP binding
k	1990447	molecular_function	U2 snRNP binding
k	1990904	cellular_component	ribonucleoprotein complex
l	0000244	biological_process	spliceosomal tri-snRNP complex assembly
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005683	cellular_component	U7 snRNP
l	0005684	cellular_component	U2-type spliceosomal complex
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005689	cellular_component	U12-type spliceosomal complex
l	0005690	cellular_component	U4atac snRNP
l	0005697	cellular_component	telomerase holoenzyme complex
l	0005829	cellular_component	cytosol
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034693	cellular_component	U11/U12 snRNP
l	0034709	cellular_component	methylosome
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
l	0071001	cellular_component	U4/U6 snRNP
l	0071002	cellular_component	U4atac/U6atac snRNP
l	0071005	cellular_component	U2-type precatalytic spliceosome
l	0071006	cellular_component	U2-type catalytic step 1 spliceosome
l	0071007	cellular_component	U2-type catalytic step 2 spliceosome
l	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0071014	cellular_component	post-mRNA release spliceosomal complex
l	0071016	cellular_component	U12-type precatalytic spliceosome
l	0071018	cellular_component	U12-type catalytic step 2 spliceosome
l	0071020	cellular_component	post-spliceosomal complex
l	0071045	biological_process	nuclear histone mRNA catabolic process
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
m	0000244	biological_process	spliceosomal tri-snRNP complex assembly
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005683	cellular_component	U7 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005690	cellular_component	U4atac snRNP
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0022618	biological_process	protein-RNA complex assembly
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034693	cellular_component	U11/U12 snRNP
m	0034709	cellular_component	methylosome
m	0034715	cellular_component	pICln-Sm protein complex
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
m	0071001	cellular_component	U4/U6 snRNP
m	0071002	cellular_component	U4atac/U6atac snRNP
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071006	cellular_component	U2-type catalytic step 1 spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
m	0071011	cellular_component	precatalytic spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0071014	cellular_component	post-mRNA release spliceosomal complex
m	0071016	cellular_component	U12-type precatalytic spliceosome
m	0071018	cellular_component	U12-type catalytic step 2 spliceosome
m	0071020	cellular_component	post-spliceosomal complex
m	0071045	biological_process	nuclear histone mRNA catabolic process
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
n	0000244	biological_process	spliceosomal tri-snRNP complex assembly
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005683	cellular_component	U7 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005690	cellular_component	U4atac snRNP
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034693	cellular_component	U11/U12 snRNP
n	0034709	cellular_component	methylosome
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0043186	cellular_component	P granule
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
n	0071001	cellular_component	U4/U6 snRNP
n	0071002	cellular_component	U4atac/U6atac snRNP
n	0071004	cellular_component	U2-type prespliceosome
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071006	cellular_component	U2-type catalytic step 1 spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0071014	cellular_component	post-mRNA release spliceosomal complex
n	0071016	cellular_component	U12-type precatalytic spliceosome
n	0071018	cellular_component	U12-type catalytic step 2 spliceosome
n	0071020	cellular_component	post-spliceosomal complex
n	0071045	biological_process	nuclear histone mRNA catabolic process
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990904	cellular_component	ribonucleoprotein complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	27
Details	Zinc finger: {"description":"CHHC U11-48K-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---