9G8J

Structure of K+-dependent Na+-PPase from Thermotoga maritima in complex with zoledronate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004427	molecular_function	inorganic diphosphate phosphatase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0009678	molecular_function	diphosphate hydrolysis-driven proton transmembrane transporter activity
A	0015081	molecular_function	sodium ion transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0030955	molecular_function	potassium ion binding
A	0035725	biological_process	sodium ion transmembrane transport
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0000287	molecular_function	magnesium ion binding
B	0004427	molecular_function	inorganic diphosphate phosphatase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0009678	molecular_function	diphosphate hydrolysis-driven proton transmembrane transporter activity
B	0015081	molecular_function	sodium ion transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0030955	molecular_function	potassium ion binding
B	0035725	biological_process	sodium ion transmembrane transport
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0000287	molecular_function	magnesium ion binding
C	0004427	molecular_function	inorganic diphosphate phosphatase activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0009678	molecular_function	diphosphate hydrolysis-driven proton transmembrane transporter activity
C	0015081	molecular_function	sodium ion transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0030955	molecular_function	potassium ion binding
C	0035725	biological_process	sodium ion transmembrane transport
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
D	0000287	molecular_function	magnesium ion binding
D	0004427	molecular_function	inorganic diphosphate phosphatase activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0009678	molecular_function	diphosphate hydrolysis-driven proton transmembrane transporter activity
D	0015081	molecular_function	sodium ion transmembrane transporter activity
D	0016020	cellular_component	membrane
D	0030955	molecular_function	potassium ion binding
D	0035725	biological_process	sodium ion transmembrane transport
D	0042803	molecular_function	protein homodimerization activity
D	0046872	molecular_function	metal ion binding
D	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1600
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	270
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"22837527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	686
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"22837527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22837527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22837527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AV3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Site: {"description":"Important for ion transport","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Site: {"description":"Determinant of potassium dependence","evidences":[{"source":"HAMAP-Rule","id":"MF_01129","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---