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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9G4U

Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 31

This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsRegion: {"description":"Gate loop 1","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues20
DetailsRegion: {"description":"Interaction with METTL14","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues17
DetailsRegion: {"description":"Interphase loop","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues22
DetailsRegion: {"description":"Positively charged region required for RNA-binding","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsRegion: {"description":"Gate loop 2","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27373337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27627798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L6D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L6E","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27373337","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K7W","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsSite: {"description":"Interaction with METTL14","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues14
DetailsRegion: {"description":"Interaction with METTL3","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsSite: {"description":"Interaction with METTL3","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246031

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