9FY4

Crystal structure of Heme-Oxygenase mutant I143K from Corynebacterium diphtheriae complexed with Cobalt-porphyrine (HumO-Co(III))

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004392	molecular_function	heme oxygenase (decyclizing) activity
A	0006788	biological_process	heme oxidation
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0042167	biological_process	heme catabolic process
A	0046872	molecular_function	metal ion binding
H	0004392	molecular_function	heme oxygenase (decyclizing) activity
H	0006788	biological_process	heme oxidation
H	0006979	biological_process	response to oxidative stress
H	0016491	molecular_function	oxidoreductase activity
H	0020037	molecular_function	heme binding
H	0042167	biological_process	heme catabolic process
H	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00593
Number of Residues	11
Details	HEME_OXYGENASE Heme oxygenase signature. LVAHHYVRYLG

Chain	Residue	Details
A	LEU125-GLY135

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 795

Chain	Residue	Details
A	HIS25	metal ligand
A	TYR53	activator, electrostatic stabiliser
A	VAL131	activator
A	ARG132	activator
A	GLY135	steric role
A	ASP136	modifies pKa
A	GLY140	steric role

---

site_id	MCSA2
Number of Residues	7
Details	M-CSA 795

Chain

Residue

Details

---