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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9FXU

Crystal Structure of Autotaxin (ENPP2) with Type VI Inhibitor, a Novel Class of Inhibitors with Three-Point Lock Binding Mode

This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
site_idPS00524
Number of Residues21
DetailsSMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyss.CChDFdelC
ChainResidueDetails
ACYS73-CYS93
ACYS117-CYS137
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues44
DetailsDomain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues21
DetailsRegion: {"description":"Required for secretion","evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsMotif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12633853","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27268273","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21240271","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27075612","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27268273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27660691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XRG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LQQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21240271","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27075612","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27268273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27660691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XRG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LQQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21240271","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27075612","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27268273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XRG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LQQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21240271","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27075612","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27268273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XRG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LQQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21240271","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27075612","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27268273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XRG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsSite: {"description":"Essential for catalytic activity","evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21240271","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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