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9FQM

Helical reconstruction of human TIRAP

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0002755biological_processMyD88-dependent toll-like receptor signaling pathway
A0005080molecular_functionprotein kinase C binding
A0005515molecular_functionprotein binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006954biological_processinflammatory response
A0007166biological_processcell surface receptor signaling pathway
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0030099biological_processmyeloid cell differentiation
A0030139cellular_componentendocytic vesicle
A0030674molecular_functionprotein-macromolecule adaptor activity
A0030890biological_processpositive regulation of B cell proliferation
A0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
A0031334biological_processpositive regulation of protein-containing complex assembly
A0032496biological_processresponse to lipopolysaccharide
A0032587cellular_componentruffle membrane
A0032648biological_processregulation of interferon-beta production
A0032735biological_processpositive regulation of interleukin-12 production
A0032738biological_processpositive regulation of interleukin-15 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0034137biological_processpositive regulation of toll-like receptor 2 signaling pathway
A0034141biological_processpositive regulation of toll-like receptor 3 signaling pathway
A0034142biological_processtoll-like receptor 4 signaling pathway
A0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
A0035591molecular_functionsignaling adaptor activity
A0035662molecular_functionToll-like receptor 4 binding
A0035663molecular_functionToll-like receptor 2 binding
A0035665biological_processTIRAP-dependent toll-like receptor 4 signaling pathway
A0038123biological_processtoll-like receptor TLR1:TLR2 signaling pathway
A0042802molecular_functionidentical protein binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0045087biological_processinnate immune response
A0045088biological_processregulation of innate immune response
A0046330biological_processpositive regulation of JNK cascade
A0050830biological_processdefense response to Gram-positive bacterium
A0060090molecular_functionmolecular adaptor activity
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070935biological_process3'-UTR-mediated mRNA stabilization
A0071221biological_processcellular response to bacterial lipopeptide
A0071223biological_processcellular response to lipoteichoic acid
A0090023biological_processpositive regulation of neutrophil chemotaxis
A2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B0002376biological_processimmune system process
B0002755biological_processMyD88-dependent toll-like receptor signaling pathway
B0005080molecular_functionprotein kinase C binding
B0005515molecular_functionprotein binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006954biological_processinflammatory response
B0007166biological_processcell surface receptor signaling pathway
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0030099biological_processmyeloid cell differentiation
B0030139cellular_componentendocytic vesicle
B0030674molecular_functionprotein-macromolecule adaptor activity
B0030890biological_processpositive regulation of B cell proliferation
B0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
B0031334biological_processpositive regulation of protein-containing complex assembly
B0032496biological_processresponse to lipopolysaccharide
B0032587cellular_componentruffle membrane
B0032648biological_processregulation of interferon-beta production
B0032735biological_processpositive regulation of interleukin-12 production
B0032738biological_processpositive regulation of interleukin-15 production
B0032755biological_processpositive regulation of interleukin-6 production
B0032757biological_processpositive regulation of interleukin-8 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0034137biological_processpositive regulation of toll-like receptor 2 signaling pathway
B0034141biological_processpositive regulation of toll-like receptor 3 signaling pathway
B0034142biological_processtoll-like receptor 4 signaling pathway
B0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
B0035591molecular_functionsignaling adaptor activity
B0035662molecular_functionToll-like receptor 4 binding
B0035663molecular_functionToll-like receptor 2 binding
B0035665biological_processTIRAP-dependent toll-like receptor 4 signaling pathway
B0038123biological_processtoll-like receptor TLR1:TLR2 signaling pathway
B0042802molecular_functionidentical protein binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0045087biological_processinnate immune response
B0045088biological_processregulation of innate immune response
B0046330biological_processpositive regulation of JNK cascade
B0050830biological_processdefense response to Gram-positive bacterium
B0060090molecular_functionmolecular adaptor activity
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070935biological_process3'-UTR-mediated mRNA stabilization
B0071221biological_processcellular response to bacterial lipopeptide
B0071223biological_processcellular response to lipoteichoic acid
B0090023biological_processpositive regulation of neutrophil chemotaxis
B2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C0002376biological_processimmune system process
C0002755biological_processMyD88-dependent toll-like receptor signaling pathway
C0005080molecular_functionprotein kinase C binding
C0005515molecular_functionprotein binding
C0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006954biological_processinflammatory response
C0007166biological_processcell surface receptor signaling pathway
C0009986cellular_componentcell surface
C0016020cellular_componentmembrane
C0030099biological_processmyeloid cell differentiation
C0030139cellular_componentendocytic vesicle
C0030674molecular_functionprotein-macromolecule adaptor activity
C0030890biological_processpositive regulation of B cell proliferation
C0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
C0031334biological_processpositive regulation of protein-containing complex assembly
C0032496biological_processresponse to lipopolysaccharide
C0032587cellular_componentruffle membrane
C0032648biological_processregulation of interferon-beta production
C0032735biological_processpositive regulation of interleukin-12 production
C0032738biological_processpositive regulation of interleukin-15 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032757biological_processpositive regulation of interleukin-8 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0034137biological_processpositive regulation of toll-like receptor 2 signaling pathway
C0034141biological_processpositive regulation of toll-like receptor 3 signaling pathway
C0034142biological_processtoll-like receptor 4 signaling pathway
C0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
C0035591molecular_functionsignaling adaptor activity
C0035662molecular_functionToll-like receptor 4 binding
C0035663molecular_functionToll-like receptor 2 binding
C0035665biological_processTIRAP-dependent toll-like receptor 4 signaling pathway
C0038123biological_processtoll-like receptor TLR1:TLR2 signaling pathway
C0042802molecular_functionidentical protein binding
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0045087biological_processinnate immune response
C0045088biological_processregulation of innate immune response
C0046330biological_processpositive regulation of JNK cascade
C0050830biological_processdefense response to Gram-positive bacterium
C0060090molecular_functionmolecular adaptor activity
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070935biological_process3'-UTR-mediated mRNA stabilization
C0071221biological_processcellular response to bacterial lipopeptide
C0071223biological_processcellular response to lipoteichoic acid
C0090023biological_processpositive regulation of neutrophil chemotaxis
C2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D0002376biological_processimmune system process
D0002755biological_processMyD88-dependent toll-like receptor signaling pathway
D0005080molecular_functionprotein kinase C binding
D0005515molecular_functionprotein binding
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006954biological_processinflammatory response
D0007166biological_processcell surface receptor signaling pathway
D0009986cellular_componentcell surface
D0016020cellular_componentmembrane
D0030099biological_processmyeloid cell differentiation
D0030139cellular_componentendocytic vesicle
D0030674molecular_functionprotein-macromolecule adaptor activity
D0030890biological_processpositive regulation of B cell proliferation
D0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
D0031334biological_processpositive regulation of protein-containing complex assembly
D0032496biological_processresponse to lipopolysaccharide
D0032587cellular_componentruffle membrane
D0032648biological_processregulation of interferon-beta production
D0032735biological_processpositive regulation of interleukin-12 production
D0032738biological_processpositive regulation of interleukin-15 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032757biological_processpositive regulation of interleukin-8 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0034137biological_processpositive regulation of toll-like receptor 2 signaling pathway
D0034141biological_processpositive regulation of toll-like receptor 3 signaling pathway
D0034142biological_processtoll-like receptor 4 signaling pathway
D0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
D0035591molecular_functionsignaling adaptor activity
D0035662molecular_functionToll-like receptor 4 binding
D0035663molecular_functionToll-like receptor 2 binding
D0035665biological_processTIRAP-dependent toll-like receptor 4 signaling pathway
D0038123biological_processtoll-like receptor TLR1:TLR2 signaling pathway
D0042802molecular_functionidentical protein binding
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0045087biological_processinnate immune response
D0045088biological_processregulation of innate immune response
D0046330biological_processpositive regulation of JNK cascade
D0050830biological_processdefense response to Gram-positive bacterium
D0060090molecular_functionmolecular adaptor activity
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070935biological_process3'-UTR-mediated mRNA stabilization
D0071221biological_processcellular response to bacterial lipopeptide
D0071223biological_processcellular response to lipoteichoic acid
D0090023biological_processpositive regulation of neutrophil chemotaxis
D2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
E0002376biological_processimmune system process
E0002755biological_processMyD88-dependent toll-like receptor signaling pathway
E0005080molecular_functionprotein kinase C binding
E0005515molecular_functionprotein binding
E0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006954biological_processinflammatory response
E0007166biological_processcell surface receptor signaling pathway
E0009986cellular_componentcell surface
E0016020cellular_componentmembrane
E0030099biological_processmyeloid cell differentiation
E0030139cellular_componentendocytic vesicle
E0030674molecular_functionprotein-macromolecule adaptor activity
E0030890biological_processpositive regulation of B cell proliferation
E0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
E0031334biological_processpositive regulation of protein-containing complex assembly
E0032496biological_processresponse to lipopolysaccharide
E0032587cellular_componentruffle membrane
E0032648biological_processregulation of interferon-beta production
E0032735biological_processpositive regulation of interleukin-12 production
E0032738biological_processpositive regulation of interleukin-15 production
E0032755biological_processpositive regulation of interleukin-6 production
E0032757biological_processpositive regulation of interleukin-8 production
E0032760biological_processpositive regulation of tumor necrosis factor production
E0034137biological_processpositive regulation of toll-like receptor 2 signaling pathway
E0034141biological_processpositive regulation of toll-like receptor 3 signaling pathway
E0034142biological_processtoll-like receptor 4 signaling pathway
E0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
E0035591molecular_functionsignaling adaptor activity
E0035662molecular_functionToll-like receptor 4 binding
E0035663molecular_functionToll-like receptor 2 binding
E0035665biological_processTIRAP-dependent toll-like receptor 4 signaling pathway
E0038123biological_processtoll-like receptor TLR1:TLR2 signaling pathway
E0042802molecular_functionidentical protein binding
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0045087biological_processinnate immune response
E0045088biological_processregulation of innate immune response
E0046330biological_processpositive regulation of JNK cascade
E0050830biological_processdefense response to Gram-positive bacterium
E0060090molecular_functionmolecular adaptor activity
E0070374biological_processpositive regulation of ERK1 and ERK2 cascade
E0070935biological_process3'-UTR-mediated mRNA stabilization
E0071221biological_processcellular response to bacterial lipopeptide
E0071223biological_processcellular response to lipoteichoic acid
E0090023biological_processpositive regulation of neutrophil chemotaxis
E2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
E2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
F0002376biological_processimmune system process
F0002755biological_processMyD88-dependent toll-like receptor signaling pathway
F0005080molecular_functionprotein kinase C binding
F0005515molecular_functionprotein binding
F0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006954biological_processinflammatory response
F0007166biological_processcell surface receptor signaling pathway
F0009986cellular_componentcell surface
F0016020cellular_componentmembrane
F0030099biological_processmyeloid cell differentiation
F0030139cellular_componentendocytic vesicle
F0030674molecular_functionprotein-macromolecule adaptor activity
F0030890biological_processpositive regulation of B cell proliferation
F0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
F0031334biological_processpositive regulation of protein-containing complex assembly
F0032496biological_processresponse to lipopolysaccharide
F0032587cellular_componentruffle membrane
F0032648biological_processregulation of interferon-beta production
F0032735biological_processpositive regulation of interleukin-12 production
F0032738biological_processpositive regulation of interleukin-15 production
F0032755biological_processpositive regulation of interleukin-6 production
F0032757biological_processpositive regulation of interleukin-8 production
F0032760biological_processpositive regulation of tumor necrosis factor production
F0034137biological_processpositive regulation of toll-like receptor 2 signaling pathway
F0034141biological_processpositive regulation of toll-like receptor 3 signaling pathway
F0034142biological_processtoll-like receptor 4 signaling pathway
F0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
F0035591molecular_functionsignaling adaptor activity
F0035662molecular_functionToll-like receptor 4 binding
F0035663molecular_functionToll-like receptor 2 binding
F0035665biological_processTIRAP-dependent toll-like receptor 4 signaling pathway
F0038123biological_processtoll-like receptor TLR1:TLR2 signaling pathway
F0042802molecular_functionidentical protein binding
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0045087biological_processinnate immune response
F0045088biological_processregulation of innate immune response
F0046330biological_processpositive regulation of JNK cascade
F0050830biological_processdefense response to Gram-positive bacterium
F0060090molecular_functionmolecular adaptor activity
F0070374biological_processpositive regulation of ERK1 and ERK2 cascade
F0070935biological_process3'-UTR-mediated mRNA stabilization
F0071221biological_processcellular response to bacterial lipopeptide
F0071223biological_processcellular response to lipoteichoic acid
F0090023biological_processpositive regulation of neutrophil chemotaxis
F2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
F2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
G0002376biological_processimmune system process
G0002755biological_processMyD88-dependent toll-like receptor signaling pathway
G0005080molecular_functionprotein kinase C binding
G0005515molecular_functionprotein binding
G0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006954biological_processinflammatory response
G0007166biological_processcell surface receptor signaling pathway
G0009986cellular_componentcell surface
G0016020cellular_componentmembrane
G0030099biological_processmyeloid cell differentiation
G0030139cellular_componentendocytic vesicle
G0030674molecular_functionprotein-macromolecule adaptor activity
G0030890biological_processpositive regulation of B cell proliferation
G0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
G0031334biological_processpositive regulation of protein-containing complex assembly
G0032496biological_processresponse to lipopolysaccharide
G0032587cellular_componentruffle membrane
G0032648biological_processregulation of interferon-beta production
G0032735biological_processpositive regulation of interleukin-12 production
G0032738biological_processpositive regulation of interleukin-15 production
G0032755biological_processpositive regulation of interleukin-6 production
G0032757biological_processpositive regulation of interleukin-8 production
G0032760biological_processpositive regulation of tumor necrosis factor production
G0034137biological_processpositive regulation of toll-like receptor 2 signaling pathway
G0034141biological_processpositive regulation of toll-like receptor 3 signaling pathway
G0034142biological_processtoll-like receptor 4 signaling pathway
G0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
G0035591molecular_functionsignaling adaptor activity
G0035662molecular_functionToll-like receptor 4 binding
G0035663molecular_functionToll-like receptor 2 binding
G0035665biological_processTIRAP-dependent toll-like receptor 4 signaling pathway
G0038123biological_processtoll-like receptor TLR1:TLR2 signaling pathway
G0042802molecular_functionidentical protein binding
G0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
G0045087biological_processinnate immune response
G0045088biological_processregulation of innate immune response
G0046330biological_processpositive regulation of JNK cascade
G0050830biological_processdefense response to Gram-positive bacterium
G0060090molecular_functionmolecular adaptor activity
G0070374biological_processpositive regulation of ERK1 and ERK2 cascade
G0070935biological_process3'-UTR-mediated mRNA stabilization
G0071221biological_processcellular response to bacterial lipopeptide
G0071223biological_processcellular response to lipoteichoic acid
G0090023biological_processpositive regulation of neutrophil chemotaxis
G2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
G2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
H0002376biological_processimmune system process
H0002755biological_processMyD88-dependent toll-like receptor signaling pathway
H0005080molecular_functionprotein kinase C binding
H0005515molecular_functionprotein binding
H0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006954biological_processinflammatory response
H0007166biological_processcell surface receptor signaling pathway
H0009986cellular_componentcell surface
H0016020cellular_componentmembrane
H0030099biological_processmyeloid cell differentiation
H0030139cellular_componentendocytic vesicle
H0030674molecular_functionprotein-macromolecule adaptor activity
H0030890biological_processpositive regulation of B cell proliferation
H0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
H0031334biological_processpositive regulation of protein-containing complex assembly
H0032496biological_processresponse to lipopolysaccharide
H0032587cellular_componentruffle membrane
H0032648biological_processregulation of interferon-beta production
H0032735biological_processpositive regulation of interleukin-12 production
H0032738biological_processpositive regulation of interleukin-15 production
H0032755biological_processpositive regulation of interleukin-6 production
H0032757biological_processpositive regulation of interleukin-8 production
H0032760biological_processpositive regulation of tumor necrosis factor production
H0034137biological_processpositive regulation of toll-like receptor 2 signaling pathway
H0034141biological_processpositive regulation of toll-like receptor 3 signaling pathway
H0034142biological_processtoll-like receptor 4 signaling pathway
H0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
H0035591molecular_functionsignaling adaptor activity
H0035662molecular_functionToll-like receptor 4 binding
H0035663molecular_functionToll-like receptor 2 binding
H0035665biological_processTIRAP-dependent toll-like receptor 4 signaling pathway
H0038123biological_processtoll-like receptor TLR1:TLR2 signaling pathway
H0042802molecular_functionidentical protein binding
H0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
H0045087biological_processinnate immune response
H0045088biological_processregulation of innate immune response
H0046330biological_processpositive regulation of JNK cascade
H0050830biological_processdefense response to Gram-positive bacterium
H0060090molecular_functionmolecular adaptor activity
H0070374biological_processpositive regulation of ERK1 and ERK2 cascade
H0070935biological_process3'-UTR-mediated mRNA stabilization
H0071221biological_processcellular response to bacterial lipopeptide
H0071223biological_processcellular response to lipoteichoic acid
H0090023biological_processpositive regulation of neutrophil chemotaxis
H2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
H2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1032
DetailsDomain: {"description":"TIR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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