9FMX

Aerolysin Y221G - prepore

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001897	biological_process	symbiont-mediated cytolysis of host cell
A	0005576	cellular_component	extracellular region
A	0016020	cellular_component	membrane
A	0020002	cellular_component	host cell plasma membrane
A	0033644	cellular_component	host cell membrane
A	0035821	biological_process	modulation of process of another organism
A	0042802	molecular_function	identical protein binding
A	0090729	molecular_function	toxin activity
B	0001897	biological_process	symbiont-mediated cytolysis of host cell
B	0005576	cellular_component	extracellular region
B	0016020	cellular_component	membrane
B	0020002	cellular_component	host cell plasma membrane
B	0033644	cellular_component	host cell membrane
B	0035821	biological_process	modulation of process of another organism
B	0042802	molecular_function	identical protein binding
B	0090729	molecular_function	toxin activity
C	0001897	biological_process	symbiont-mediated cytolysis of host cell
C	0005576	cellular_component	extracellular region
C	0016020	cellular_component	membrane
C	0020002	cellular_component	host cell plasma membrane
C	0033644	cellular_component	host cell membrane
C	0035821	biological_process	modulation of process of another organism
C	0042802	molecular_function	identical protein binding
C	0090729	molecular_function	toxin activity
D	0001897	biological_process	symbiont-mediated cytolysis of host cell
D	0005576	cellular_component	extracellular region
D	0016020	cellular_component	membrane
D	0020002	cellular_component	host cell plasma membrane
D	0033644	cellular_component	host cell membrane
D	0035821	biological_process	modulation of process of another organism
D	0042802	molecular_function	identical protein binding
D	0090729	molecular_function	toxin activity
E	0001897	biological_process	symbiont-mediated cytolysis of host cell
E	0005576	cellular_component	extracellular region
E	0016020	cellular_component	membrane
E	0020002	cellular_component	host cell plasma membrane
E	0033644	cellular_component	host cell membrane
E	0035821	biological_process	modulation of process of another organism
E	0042802	molecular_function	identical protein binding
E	0090729	molecular_function	toxin activity
F	0001897	biological_process	symbiont-mediated cytolysis of host cell
F	0005576	cellular_component	extracellular region
F	0016020	cellular_component	membrane
F	0020002	cellular_component	host cell plasma membrane
F	0033644	cellular_component	host cell membrane
F	0035821	biological_process	modulation of process of another organism
F	0042802	molecular_function	identical protein binding
F	0090729	molecular_function	toxin activity
G	0001897	biological_process	symbiont-mediated cytolysis of host cell
G	0005576	cellular_component	extracellular region
G	0016020	cellular_component	membrane
G	0020002	cellular_component	host cell plasma membrane
G	0033644	cellular_component	host cell membrane
G	0035821	biological_process	modulation of process of another organism
G	0042802	molecular_function	identical protein binding
G	0090729	molecular_function	toxin activity
H	0001897	biological_process	symbiont-mediated cytolysis of host cell
H	0005576	cellular_component	extracellular region
H	0016020	cellular_component	membrane
H	0020002	cellular_component	host cell plasma membrane
H	0033644	cellular_component	host cell membrane
H	0035821	biological_process	modulation of process of another organism
H	0042802	molecular_function	identical protein binding
H	0090729	molecular_function	toxin activity
I	0001897	biological_process	symbiont-mediated cytolysis of host cell
I	0005576	cellular_component	extracellular region
I	0016020	cellular_component	membrane
I	0020002	cellular_component	host cell plasma membrane
I	0033644	cellular_component	host cell membrane
I	0035821	biological_process	modulation of process of another organism
I	0042802	molecular_function	identical protein binding
I	0090729	molecular_function	toxin activity
J	0001897	biological_process	symbiont-mediated cytolysis of host cell
J	0005576	cellular_component	extracellular region
J	0016020	cellular_component	membrane
J	0020002	cellular_component	host cell plasma membrane
J	0033644	cellular_component	host cell membrane
J	0035821	biological_process	modulation of process of another organism
J	0042802	molecular_function	identical protein binding
J	0090729	molecular_function	toxin activity
K	0001897	biological_process	symbiont-mediated cytolysis of host cell
K	0005576	cellular_component	extracellular region
K	0016020	cellular_component	membrane
K	0020002	cellular_component	host cell plasma membrane
K	0033644	cellular_component	host cell membrane
K	0035821	biological_process	modulation of process of another organism
K	0042802	molecular_function	identical protein binding
K	0090729	molecular_function	toxin activity
L	0001897	biological_process	symbiont-mediated cytolysis of host cell
L	0005576	cellular_component	extracellular region
L	0016020	cellular_component	membrane
L	0020002	cellular_component	host cell plasma membrane
L	0033644	cellular_component	host cell membrane
L	0035821	biological_process	modulation of process of another organism
L	0042802	molecular_function	identical protein binding
L	0090729	molecular_function	toxin activity
M	0001897	biological_process	symbiont-mediated cytolysis of host cell
M	0005576	cellular_component	extracellular region
M	0016020	cellular_component	membrane
M	0020002	cellular_component	host cell plasma membrane
M	0033644	cellular_component	host cell membrane
M	0035821	biological_process	modulation of process of another organism
M	0042802	molecular_function	identical protein binding
M	0090729	molecular_function	toxin activity
N	0001897	biological_process	symbiont-mediated cytolysis of host cell
N	0005576	cellular_component	extracellular region
N	0016020	cellular_component	membrane
N	0020002	cellular_component	host cell plasma membrane
N	0033644	cellular_component	host cell membrane
N	0035821	biological_process	modulation of process of another organism
N	0042802	molecular_function	identical protein binding
N	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00274
Number of Residues	10
Details	AEROLYSIN Aerolysin type toxins signature. TatNWskTNT

Chain	Residue	Details
A	THR223-THR232

---

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DGDEVDV

Chain	Residue	Details
A	ASP95-VAL101

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	224
Details	Region: {"description":"Interaction with host N-linked glycan"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	448
Details	Region: {"description":"Part of the transmembrane beta-barrel after proteolytic activation of the toxin and insertion into the host membrane"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	126
Details	Region: {"description":"Interaction with glycans from host GPI-anchor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Site: {"description":"Important for oligomerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	28
Details	Site: {"description":"Important for heptamerization"}

Chain

Residue

Details

---