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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9FKF

Crystal structure of human Glucose-6-phosphate isomerase with phosphoenol pyruvate ligand

Functional Information from GO Data
ChainGOidnamespacecontents
A0001701biological_processin utero embryonic development
A0001707biological_processmesoderm formation
A0002639biological_processpositive regulation of immunoglobulin production
A0004347molecular_functionglucose-6-phosphate isomerase activity
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005975biological_processcarbohydrate metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0006096biological_processglycolytic process
A0006959biological_processhumoral immune response
A0007165biological_processsignal transduction
A0007599biological_processhemostasis
A0007611biological_processlearning or memory
A0008083molecular_functiongrowth factor activity
A0010595biological_processpositive regulation of endothelial cell migration
A0016020cellular_componentmembrane
A0016853molecular_functionisomerase activity
A0016857molecular_functionracemase and epimerase activity, acting on carbohydrates and derivatives
A0031625molecular_functionubiquitin protein ligase binding
A0032355biological_processresponse to estradiol
A0032570biological_processresponse to progesterone
A0033574biological_processresponse to testosterone
A0034101biological_processerythrocyte homeostasis
A0034774cellular_componentsecretory granule lumen
A0035902biological_processresponse to immobilization stress
A0035994biological_processresponse to muscle stretch
A0042593biological_processglucose homeostasis
A0043066biological_processnegative regulation of apoptotic process
A0046686biological_processresponse to cadmium ion
A0048029molecular_functionmonosaccharide binding
A0051156biological_processglucose 6-phosphate metabolic process
A0060170cellular_componentciliary membrane
A0061621biological_processcanonical glycolysis
A0070062cellular_componentextracellular exosome
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A1904813cellular_componentficolin-1-rich granule lumen
B0001701biological_processin utero embryonic development
B0001707biological_processmesoderm formation
B0002639biological_processpositive regulation of immunoglobulin production
B0004347molecular_functionglucose-6-phosphate isomerase activity
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005975biological_processcarbohydrate metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0006096biological_processglycolytic process
B0006959biological_processhumoral immune response
B0007165biological_processsignal transduction
B0007599biological_processhemostasis
B0007611biological_processlearning or memory
B0008083molecular_functiongrowth factor activity
B0010595biological_processpositive regulation of endothelial cell migration
B0016020cellular_componentmembrane
B0016853molecular_functionisomerase activity
B0016857molecular_functionracemase and epimerase activity, acting on carbohydrates and derivatives
B0031625molecular_functionubiquitin protein ligase binding
B0032355biological_processresponse to estradiol
B0032570biological_processresponse to progesterone
B0033574biological_processresponse to testosterone
B0034101biological_processerythrocyte homeostasis
B0034774cellular_componentsecretory granule lumen
B0035902biological_processresponse to immobilization stress
B0035994biological_processresponse to muscle stretch
B0042593biological_processglucose homeostasis
B0043066biological_processnegative regulation of apoptotic process
B0046686biological_processresponse to cadmium ion
B0048029molecular_functionmonosaccharide binding
B0051156biological_processglucose 6-phosphate metabolic process
B0060170cellular_componentciliary membrane
B0061621biological_processcanonical glycolysis
B0070062cellular_componentextracellular exosome
B1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
B1904813cellular_componentficolin-1-rich granule lumen
C0001701biological_processin utero embryonic development
C0001707biological_processmesoderm formation
C0002639biological_processpositive regulation of immunoglobulin production
C0004347molecular_functionglucose-6-phosphate isomerase activity
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005975biological_processcarbohydrate metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0006096biological_processglycolytic process
C0006959biological_processhumoral immune response
C0007165biological_processsignal transduction
C0007599biological_processhemostasis
C0007611biological_processlearning or memory
C0008083molecular_functiongrowth factor activity
C0010595biological_processpositive regulation of endothelial cell migration
C0016020cellular_componentmembrane
C0016853molecular_functionisomerase activity
C0016857molecular_functionracemase and epimerase activity, acting on carbohydrates and derivatives
C0031625molecular_functionubiquitin protein ligase binding
C0032355biological_processresponse to estradiol
C0032570biological_processresponse to progesterone
C0033574biological_processresponse to testosterone
C0034101biological_processerythrocyte homeostasis
C0034774cellular_componentsecretory granule lumen
C0035902biological_processresponse to immobilization stress
C0035994biological_processresponse to muscle stretch
C0042593biological_processglucose homeostasis
C0043066biological_processnegative regulation of apoptotic process
C0046686biological_processresponse to cadmium ion
C0048029molecular_functionmonosaccharide binding
C0051156biological_processglucose 6-phosphate metabolic process
C0060170cellular_componentciliary membrane
C0061621biological_processcanonical glycolysis
C0070062cellular_componentextracellular exosome
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C1904813cellular_componentficolin-1-rich granule lumen
D0001701biological_processin utero embryonic development
D0001707biological_processmesoderm formation
D0002639biological_processpositive regulation of immunoglobulin production
D0004347molecular_functionglucose-6-phosphate isomerase activity
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005975biological_processcarbohydrate metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0006096biological_processglycolytic process
D0006959biological_processhumoral immune response
D0007165biological_processsignal transduction
D0007599biological_processhemostasis
D0007611biological_processlearning or memory
D0008083molecular_functiongrowth factor activity
D0010595biological_processpositive regulation of endothelial cell migration
D0016020cellular_componentmembrane
D0016853molecular_functionisomerase activity
D0016857molecular_functionracemase and epimerase activity, acting on carbohydrates and derivatives
D0031625molecular_functionubiquitin protein ligase binding
D0032355biological_processresponse to estradiol
D0032570biological_processresponse to progesterone
D0033574biological_processresponse to testosterone
D0034101biological_processerythrocyte homeostasis
D0034774cellular_componentsecretory granule lumen
D0035902biological_processresponse to immobilization stress
D0035994biological_processresponse to muscle stretch
D0042593biological_processglucose homeostasis
D0043066biological_processnegative regulation of apoptotic process
D0046686biological_processresponse to cadmium ion
D0048029molecular_functionmonosaccharide binding
D0051156biological_processglucose 6-phosphate metabolic process
D0060170cellular_componentciliary membrane
D0061621biological_processcanonical glycolysis
D0070062cellular_componentextracellular exosome
D1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
D1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00174
Number of Residues18
DetailsP_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. GiIWdinsFDQwGVElgK
ChainResidueDetails
AGLY502-LYS519
site_idPS00765
Number of Residues14
DetailsP_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DwVGGRYSLwSAIG
ChainResidueDetails
AASP268-GLY281
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11371164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12573240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12777791","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsActive site: {"evidences":[{"source":"PubMed","id":"11371164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12573240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12777791","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P06745","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2004","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"29775581","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"11004567","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15637053","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q6P6V0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P06745","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

244693

PDB entries from 2025-11-12

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