9FH4
Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 3
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | HIS6 | |
| E | HIS14 | |
| F | HIS12 | |
| F | HIS20 | |
| G | HIS6 | |
| G | HIS14 | |
| H | HIS12 | |
| H | HIS20 | |
| I | HIS6 | |
| I | HIS14 | |
| J | HIS12 | |
| A | HIS14 | |
| J | HIS20 | |
| B | HIS12 | |
| B | HIS20 | |
| C | HIS6 | |
| C | HIS14 | |
| D | HIS12 | |
| D | HIS20 | |
| E | HIS6 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| A | TYR10 | |
| J | TYR16 | |
| B | TYR16 | |
| C | TYR10 | |
| D | TYR16 | |
| E | TYR10 | |
| F | TYR16 | |
| G | TYR10 | |
| H | TYR16 | |
| I | TYR10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | HIS13 | |
| J | HIS19 | |
| B | HIS19 | |
| C | HIS13 | |
| D | HIS19 | |
| E | HIS13 | |
| F | HIS19 | |
| G | HIS13 | |
| H | HIS19 | |
| I | HIS13 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| A | ASP1 | |
| J | ASP7 | |
| B | ASP7 | |
| C | ASP1 | |
| D | ASP7 | |
| E | ASP1 | |
| F | ASP7 | |
| G | ASP1 | |
| H | ASP7 | |
| I | ASP1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| A | ASP7 | |
| J | ASP13 | |
| B | ASP13 | |
| C | ASP7 | |
| D | ASP13 | |
| E | ASP7 | |
| F | ASP13 | |
| G | ASP7 | |
| H | ASP13 | |
| I | ASP7 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| A | LYS16 | |
| J | LYS22 | |
| B | LYS22 | |
| C | LYS16 | |
| D | LYS22 | |
| E | LYS16 | |
| F | LYS22 | |
| G | LYS16 | |
| H | LYS22 | |
| I | LYS16 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
| Chain | Residue | Details |
| A | GLY25 | |
| J | GLY25 | |
| B | GLY25 | |
| C | GLY25 | |
| D | GLY25 | |
| E | GLY25 | |
| F | GLY25 | |
| G | GLY25 | |
| H | GLY25 | |
| I | GLY25 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | SITE: Implicated in free radical propagation => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL39 | |
| J | VAL39 | |
| B | VAL39 | |
| C | VAL39 | |
| D | VAL39 | |
| E | VAL39 | |
| F | VAL39 | |
| G | VAL39 | |
| H | VAL39 | |
| I | VAL39 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332 |
| Chain | Residue | Details |
| A | ILE41 | |
| J | ILE41 | |
| B | ILE41 | |
| C | ILE41 | |
| D | ILE41 | |
| E | ILE41 | |
| F | ILE41 | |
| G | ILE41 | |
| H | ILE41 | |
| I | ILE41 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| A | TYR10 | |
| J | TYR16 | |
| B | TYR16 | |
| C | TYR10 | |
| D | TYR16 | |
| E | TYR10 | |
| F | TYR16 | |
| G | TYR10 | |
| H | TYR16 | |
| I | TYR10 |
