9FH2
Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 1
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | HIS-2 | |
| E | HIS6 | |
| F | HIS-2 | |
| F | HIS6 | |
| G | HIS-2 | |
| G | HIS6 | |
| H | HIS-2 | |
| H | HIS6 | |
| I | HIS-2 | |
| I | HIS6 | |
| J | HIS-2 | |
| A | HIS6 | |
| J | HIS6 | |
| B | HIS-2 | |
| B | HIS6 | |
| C | HIS-2 | |
| C | HIS6 | |
| D | HIS-2 | |
| D | HIS6 | |
| E | HIS-2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| A | TYR2 | |
| J | TYR2 | |
| B | TYR2 | |
| C | TYR2 | |
| D | TYR2 | |
| E | TYR2 | |
| F | TYR2 | |
| G | TYR2 | |
| H | TYR2 | |
| I | TYR2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | HIS5 | |
| J | HIS5 | |
| B | HIS5 | |
| C | HIS5 | |
| D | HIS5 | |
| E | HIS5 | |
| F | HIS5 | |
| G | HIS5 | |
| H | HIS5 | |
| I | HIS5 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| A | ASP-7 | |
| J | ASP-7 | |
| B | ASP-7 | |
| C | ASP-7 | |
| D | ASP-7 | |
| E | ASP-7 | |
| F | ASP-7 | |
| G | ASP-7 | |
| H | ASP-7 | |
| I | ASP-7 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| A | ASP-1 | |
| J | ASP-1 | |
| B | ASP-1 | |
| C | ASP-1 | |
| D | ASP-1 | |
| E | ASP-1 | |
| F | ASP-1 | |
| G | ASP-1 | |
| H | ASP-1 | |
| I | ASP-1 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| A | LYS8 | |
| J | LYS8 | |
| B | LYS8 | |
| C | LYS8 | |
| D | LYS8 | |
| E | LYS8 | |
| F | LYS8 | |
| G | LYS8 | |
| H | LYS8 | |
| I | LYS8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
| Chain | Residue | Details |
| A | GLY11 | |
| J | GLY11 | |
| B | GLY11 | |
| C | GLY11 | |
| D | GLY11 | |
| E | GLY11 | |
| F | GLY11 | |
| G | GLY11 | |
| H | GLY11 | |
| I | GLY11 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | SITE: Implicated in free radical propagation => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL25 | |
| J | VAL25 | |
| B | VAL25 | |
| C | VAL25 | |
| D | VAL25 | |
| E | VAL25 | |
| F | VAL25 | |
| G | VAL25 | |
| H | VAL25 | |
| I | VAL25 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332 |
| Chain | Residue | Details |
| A | ILE27 | |
| J | ILE27 | |
| B | ILE27 | |
| C | ILE27 | |
| D | ILE27 | |
| E | ILE27 | |
| F | ILE27 | |
| G | ILE27 | |
| H | ILE27 | |
| I | ILE27 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| A | TYR2 | |
| J | TYR2 | |
| B | TYR2 | |
| C | TYR2 | |
| D | TYR2 | |
| E | TYR2 | |
| F | TYR2 | |
| G | TYR2 | |
| H | TYR2 | |
| I | TYR2 |
