9FG6
Cryo-EM structure of the full-length alpha1beta3 GABA(A) receptor in complex with GABA and HSM in the long-lived symmetric desensitised state
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC |
| Chain | Residue | Details |
| B | CYS136-CYS150 | |
| A | CYS139-CYS153 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 693 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:24909990 |
| Chain | Residue | Details |
| B | ARG1-PHE221 | |
| B | LEU268-LYS279 | |
| C | ARG1-PHE221 | |
| C | LEU268-LYS279 | |
| E | ARG1-PHE221 | |
| E | LEU268-LYS279 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 255 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ILE222-ILE242 | |
| E | SER247-HIS267 | |
| E | ALA280-ASN303 | |
| E | ILE448-TYR470 | |
| B | SER247-HIS267 | |
| B | ALA280-ASN303 | |
| B | ILE448-TYR470 | |
| C | ILE222-ILE242 | |
| C | SER247-HIS267 | |
| C | ALA280-ASN303 | |
| C | ILE448-TYR470 | |
| E | ILE222-ILE242 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 363 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24909990 |
| Chain | Residue | Details |
| B | ASN243-ALA246 | |
| B | TYR304-ALA447 | |
| C | ASN243-ALA246 | |
| C | TYR304-ALA447 | |
| E | ASN243-ALA246 | |
| E | TYR304-ALA447 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | TYR471-ASN473 | |
| C | TYR471-ASN473 | |
| E | TYR471-ASN473 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24909990 |
| Chain | Residue | Details |
| B | ASP95 | |
| B | PHE200 | |
| C | ASP95 | |
| C | PHE200 | |
| E | ASP95 | |
| E | PHE200 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 9 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | TYR97 | |
| B | SER156 | |
| B | THR202 | |
| C | TYR97 | |
| C | SER156 | |
| C | THR202 | |
| E | TYR97 | |
| E | SER156 | |
| E | THR202 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | GLU155 | |
| C | GLU155 | |
| E | GLU155 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96 |
| Chain | Residue | Details |
| B | TYR157 | |
| C | TYR157 | |
| E | TYR157 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN8 | |
| C | ASN8 | |
| E | ASN8 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN80 | |
| C | ASN80 | |
| E | ASN80 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6A96, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN149 | |
| C | ASN149 | |
| E | ASN149 |
