9FEY
Cryo-EM structure of the beta3 homomeric GABA(A) receptor in complex with HSM in the short-lived symmetric bound-closed state (C1)
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC |
| Chain | Residue | Details |
| A | CYS136-CYS150 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 425 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 55 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 15 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4COF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
