9FDH
Closed Human phosphoglycerate kinase complex with BPG and ADP produced by cross-soaking a TSA crystal
Functional Information from PROSITE/UniProt
| site_id | PS00111 |
| Number of Residues | 11 |
| Details | PGLYCERATE_KINASE Phosphoglycerate kinase signature. RVVMRvDfNVP |
| Chain | Residue | Details |
| A | ARG17-PRO27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18463139, ECO:0007744|PDB:3C39, ECO:0007744|PDB:3C3A, ECO:0007744|PDB:3C3C |
| Chain | Residue | Details |
| A | VAL22 | |
| A | PHE24 | |
| A | GLN37 | |
| A | LEU121 | |
| A | HIS169 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7SIB7 |
| Chain | Residue | Details |
| A | ASP23 | |
| A | GLY238 | |
| A | GLY312 | |
| A | GLU343 | |
| A | ASP374 | |
| A | THR375 | |
| A | ASN25 | |
| A | ARG38 | |
| A | HIS62 | |
| A | ARG65 | |
| A | ARG122 | |
| A | ARG170 | |
| A | LYS215 | |
| A | LYS219 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18463139, ECO:0007744|PDB:3C39, ECO:0007744|PDB:3C3C |
| Chain | Residue | Details |
| A | SER61 | |
| A | GLY64 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18463139, ECO:0007744|PDB:3C3B, ECO:0007744|PDB:3C3C |
| Chain | Residue | Details |
| A | GLY213 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18463139, ECO:0007744|PDB:3C3A |
| Chain | Residue | Details |
| A | ALA214 | |
| A | ASP218 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18463139, ECO:0007744|PDB:3C3A, ECO:0007744|PDB:3C3C |
| Chain | Residue | Details |
| A | ALA217 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18463139, ECO:0007744|PDB:3C3B |
| Chain | Residue | Details |
| A | GLY237 | |
| A | GLY337 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18463139, ECO:0007744|PDB:3C3C |
| Chain | Residue | Details |
| A | VAL339 | |
| A | PHE342 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1 | |
| A | SER3 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P09411 |
| Chain | Residue | Details |
| A | LYS5 | |
| A | LYS190 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS10 | |
| A | LYS74 | |
| A | LYS85 | |
| A | LYS145 | |
| A | LYS198 | |
| A | LYS266 | |
| A | LYS290 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09411 |
| Chain | Residue | Details |
| A | LYS47 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P09411 |
| Chain | Residue | Details |
| A | TYR75 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09411 |
| Chain | Residue | Details |
| A | LYS90 | |
| A | LYS360 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS96 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-malonyllysine; alternate => ECO:0000269|PubMed:21908771 |
| Chain | Residue | Details |
| A | LYS130 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR195 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK1 => ECO:0000269|PubMed:26942675, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER202 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29775581 |
| Chain | Residue | Details |
| A | LYS215 | |
| A | LYS322 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674 |
| Chain | Residue | Details |
| A | LYS219 |
