9FA7

Structure of the Integrator arm module containing subunits INTS10/13/14/15 (state 3)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0007052	biological_process	mitotic spindle organization
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016180	biological_process	snRNA processing
A	0016604	cellular_component	nuclear body
A	0030317	biological_process	flagellated sperm motility
A	0032039	cellular_component	integrator complex
A	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
A	0051301	biological_process	cell division
A	0051642	biological_process	centrosome localization
A	0080154	biological_process	regulation of fertilization
A	0090435	biological_process	protein localization to nuclear envelope
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0160232	cellular_component	INTAC complex
A	0160240	biological_process	RNA polymerase II transcription initiation surveillance
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0016180	biological_process	snRNA processing
B	0032039	cellular_component	integrator complex
B	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
B	0034472	biological_process	snRNA 3'-end processing
B	0046872	molecular_function	metal ion binding
B	0160232	cellular_component	INTAC complex
B	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0016180	biological_process	snRNA processing
C	0032039	cellular_component	integrator complex
C	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
C	0160232	cellular_component	INTAC complex
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0016180	biological_process	snRNA processing
D	0032039	cellular_component	integrator complex
D	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
D	0160232	cellular_component	INTAC complex
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	202
Details	Domain: {"description":"VWFA"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38823386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38906142","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38823386","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9EOC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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