9FA4

Structure of the Integrator arm module containing subunits INTS10/13/14/15 (state 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0007052	biological_process	mitotic spindle organization
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016180	biological_process	snRNA processing
A	0016604	cellular_component	nuclear body
A	0030317	biological_process	flagellated sperm motility
A	0032039	cellular_component	integrator complex
A	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
A	0051301	biological_process	cell division
A	0051642	biological_process	centrosome localization
A	0080154	biological_process	regulation of fertilization
A	0090435	biological_process	protein localization to nuclear envelope
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0160232	cellular_component	INTAC complex
A	0160240	biological_process	RNA polymerase II transcription initiation surveillance
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0016180	biological_process	snRNA processing
B	0032039	cellular_component	integrator complex
B	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
B	0034472	biological_process	snRNA 3'-end processing
B	0046872	molecular_function	metal ion binding
B	0160232	cellular_component	INTAC complex
B	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0001654	biological_process	eye development
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0007420	biological_process	brain development
C	0032039	cellular_component	integrator complex
C	0160232	cellular_component	INTAC complex
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0016180	biological_process	snRNA processing
D	0032039	cellular_component	integrator complex
D	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
D	0160232	cellular_component	INTAC complex
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:38823386, ECO:0000269|PubMed:38906142, ECO:0007744|PDB:8PK5, ECO:0007744|PDB:9EOC

Chain	Residue	Details
B	SER10
B	SER12

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:38823386, ECO:0007744|PDB:9EOC

Chain	Residue	Details
B	THR86
D	SER382

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS418

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS611

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