9F6Q
Human NRAMP1 (SLC11A1) in an occluded state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001818 | biological_process | negative regulation of cytokine production |
| A | 0001819 | biological_process | positive regulation of cytokine production |
| A | 0002309 | biological_process | T cell proliferation involved in immune response |
| A | 0002446 | biological_process | neutrophil mediated immunity |
| A | 0002606 | biological_process | positive regulation of dendritic cell antigen processing and presentation |
| A | 0002827 | biological_process | positive regulation of T-helper 1 type immune response |
| A | 0005381 | molecular_function | iron ion transmembrane transporter activity |
| A | 0005384 | molecular_function | manganese ion transmembrane transporter activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005770 | cellular_component | late endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006828 | biological_process | manganese ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0006909 | biological_process | phagocytosis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007035 | biological_process | vacuolar acidification |
| A | 0009617 | biological_process | response to bacterium |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0015095 | molecular_function | magnesium ion transmembrane transporter activity |
| A | 0015707 | biological_process | nitrite transport |
| A | 0016020 | cellular_component | membrane |
| A | 0019730 | biological_process | antimicrobial humoral response |
| A | 0030001 | biological_process | metal ion transport |
| A | 0030026 | biological_process | intracellular manganese ion homeostasis |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0030670 | cellular_component | phagocytic vesicle membrane |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0032496 | biological_process | response to lipopolysaccharide |
| A | 0032729 | biological_process | positive regulation of type II interferon production |
| A | 0034341 | biological_process | response to type II interferon |
| A | 0034755 | biological_process | iron ion transmembrane transport |
| A | 0042060 | biological_process | wound healing |
| A | 0042116 | biological_process | macrophage activation |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0042832 | biological_process | defense response to protozoan |
| A | 0045342 | biological_process | MHC class II biosynthetic process |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0045730 | biological_process | respiratory burst |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| A | 0046915 | molecular_function | transition metal ion transmembrane transporter activity |
| A | 0048002 | biological_process | antigen processing and presentation of peptide antigen |
| A | 0048255 | biological_process | mRNA stabilization |
| A | 0050766 | biological_process | positive regulation of phagocytosis |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0051139 | molecular_function | metal cation:proton antiporter activity |
| A | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| A | 0070574 | biological_process | cadmium ion transmembrane transport |
| A | 0070821 | cellular_component | tertiary granule membrane |
| A | 0071421 | biological_process | manganese ion transmembrane transport |
| A | 0071577 | biological_process | zinc ion transmembrane transport |
| A | 0098849 | biological_process | cellular detoxification of cadmium ion |
| A | 0101003 | cellular_component | ficolin-1-rich granule membrane |
| A | 0140826 | molecular_function | zinc:proton antiporter activity |
| A | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 127 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 69 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9F6Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39824808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9F6P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
