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9F6P

Human NRAMP1 (SLC11A1) in complex with manganese, towards the inward-open state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001818biological_processnegative regulation of cytokine production
A0001819biological_processpositive regulation of cytokine production
A0002309biological_processT cell proliferation involved in immune response
A0002606biological_processpositive regulation of dendritic cell antigen processing and presentation
A0002827biological_processpositive regulation of T-helper 1 type immune response
A0005381molecular_functioniron ion transmembrane transporter activity
A0005384molecular_functionmanganese ion transmembrane transporter activity
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006826biological_processiron ion transport
A0006828biological_processmanganese ion transport
A0006879biological_processintracellular iron ion homeostasis
A0006909biological_processphagocytosis
A0006954biological_processinflammatory response
A0007035biological_processvacuolar acidification
A0009617biological_processresponse to bacterium
A0010008cellular_componentendosome membrane
A0010628biological_processpositive regulation of gene expression
A0015707biological_processnitrite transport
A0016020cellular_componentmembrane
A0019730biological_processantimicrobial humoral response
A0030001biological_processmetal ion transport
A0030026biological_processintracellular manganese ion homeostasis
A0030670cellular_componentphagocytic vesicle membrane
A0031902cellular_componentlate endosome membrane
A0032496biological_processresponse to lipopolysaccharide
A0032729biological_processpositive regulation of type II interferon production
A0034341biological_processresponse to type II interferon
A0034755biological_processiron ion transmembrane transport
A0042060biological_processwound healing
A0042116biological_processmacrophage activation
A0042742biological_processdefense response to bacterium
A0042803molecular_functionprotein homodimerization activity
A0042832biological_processdefense response to protozoan
A0045342biological_processMHC class II biosynthetic process
A0045454biological_processcell redox homeostasis
A0045730biological_processrespiratory burst
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046873molecular_functionmetal ion transmembrane transporter activity
A0046915molecular_functiontransition metal ion transmembrane transporter activity
A0048002biological_processantigen processing and presentation of peptide antigen
A0048255biological_processmRNA stabilization
A0050766biological_processpositive regulation of phagocytosis
A0050829biological_processdefense response to Gram-negative bacterium
A0051139molecular_functionmetal cation:proton antiporter activity
A0051649biological_processestablishment of localization in cell
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0070574biological_processcadmium ion transmembrane transport
A0070821cellular_componenttertiary granule membrane
A0071421biological_processmanganese ion transmembrane transport
A0098849biological_processcellular detoxification of cadmium ion
A0101003cellular_componentficolin-1-rich granule membrane
A1902600biological_processproton transmembrane transport
A1903826biological_processL-arginine transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues228
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATRP59-GLY76
ALEU430-THR450
AVAL467-LEU488
APHE497-TRP516
AALA86-LEU105
ALEU143-LEU163
AILE168-LEU187
AALA197-ALA217
ALEU241-LEU259
AALA288-GLY307
AVAL350-LEU369
AVAL401-PHE418

site_idSWS_FT_FI2
Number of Residues91
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AASN77-GLY85
ASER164-ARG167
AARG218-GLU240
AGLN308-GLY349
AARG419-ASP429
APRO489-TYR496

site_idSWS_FT_FI3
Number of Residues149
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ACYS106-GLU142
AASP188-GLU196
AHIS260-GLU287
AALA370-ARG400
ASER451-LYS466
ATHR517-GLY550

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN324
AASN338

236620

PDB entries from 2025-05-28

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