Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

9F6O

Human divalent metal transporter 1 (DMT1/SLC11A2) in complex with sybody 1, in an occluded state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005375molecular_functioncopper ion transmembrane transporter activity
A0005381molecular_functioniron ion transmembrane transporter activity
A0005384molecular_functionmanganese ion transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005773cellular_componentvacuole
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006778biological_processporphyrin-containing compound metabolic process
A0006779biological_processporphyrin-containing compound biosynthetic process
A0006783biological_processheme biosynthetic process
A0006811biological_processmonoatomic ion transport
A0006824biological_processcobalt ion transport
A0006825biological_processcopper ion transport
A0006826biological_processiron ion transport
A0006828biological_processmanganese ion transport
A0006879biological_processintracellular iron ion homeostasis
A0007611biological_processlearning or memory
A0010008cellular_componentendosome membrane
A0010039biological_processresponse to iron ion
A0015086molecular_functioncadmium ion transmembrane transporter activity
A0015087molecular_functioncobalt ion transmembrane transporter activity
A0015093molecular_functionferrous iron transmembrane transporter activity
A0015094molecular_functionlead ion transmembrane transporter activity
A0015099molecular_functionnickel cation transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015295molecular_functionsolute:proton symporter activity
A0015692biological_processlead ion transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0030001biological_processmetal ion transport
A0030026biological_processintracellular manganese ion homeostasis
A0031410cellular_componentcytoplasmic vesicle
A0031526cellular_componentbrush border membrane
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0033212biological_processiron import into cell
A0034755biological_processiron ion transmembrane transport
A0035434biological_processcopper ion transmembrane transport
A0035444biological_processnickel cation transmembrane transport
A0045177cellular_componentapical part of cell
A0045178cellular_componentbasal part of cell
A0046870molecular_functioncadmium ion binding
A0046873molecular_functionmetal ion transmembrane transporter activity
A0046915molecular_functiontransition metal ion transmembrane transporter activity
A0048471cellular_componentperinuclear region of cytoplasm
A0048813biological_processdendrite morphogenesis
A0048821biological_processerythrocyte development
A0051649biological_processestablishment of localization in cell
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0070574biological_processcadmium ion transmembrane transport
A0070826cellular_componentparaferritin complex
A0071421biological_processmanganese ion transmembrane transport
A1902600biological_processproton transmembrane transport
A1903561cellular_componentextracellular vesicle
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues221
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET30-LYS98
ALEU147-GLU183
ALYS230-GLU237
ALYS306-CYS330
AALA411-ARG437
ASER491-ILE511
AVAL528-ASP568

site_idSWS_FT_FI2
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU99-ILE119
APHE470-THR490
ALEU512-GLY532
ALEU536-TRP556
AGLY126-LEU146
ALEU184-LEU204
AILE209-ASP229
AALA238-VAL258
AALA285-VAL305
AILE331-PHE351
AVAL390-ALA410
APHE438-PHE458

site_idSWS_FT_FI3
Number of Residues82
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLU120-SER125
ASER205-ARG208
ALYS259-GLN284
APHE352-GLY389
AGLN459-ASP469
AHIS533-ALA535

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P49282
ChainResidueDetails
AMET564
ALEU567

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN365
AASN378

237735

PDB entries from 2025-06-18

PDB statisticsPDBj update infoContact PDBjnumon