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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9F6F

Human DNA polymerase epsilon bound to DNA and PCNA (closed conformation)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0008622cellular_componentepsilon DNA polymerase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0001673cellular_componentmale germ cell nucleus
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005652cellular_componentnuclear lamina
B0005654cellular_componentnucleoplasm
B0005657cellular_componentreplication fork
B0005813cellular_componentcentrosome
B0006260biological_processDNA replication
B0006272biological_processleading strand elongation
B0006275biological_processregulation of DNA replication
B0006281biological_processDNA repair
B0006287biological_processbase-excision repair, gap-filling
B0006298biological_processmismatch repair
B0006325biological_processchromatin organization
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0007507biological_processheart development
B0016604cellular_componentnuclear body
B0019899molecular_functionenzyme binding
B0019985biological_processtranslesion synthesis
B0030331molecular_functionnuclear estrogen receptor binding
B0030337molecular_functionDNA polymerase processivity factor activity
B0030855biological_processepithelial cell differentiation
B0030894cellular_componentreplisome
B0030971molecular_functionreceptor tyrosine kinase binding
B0031297biological_processreplication fork processing
B0032139molecular_functiondinucleotide insertion or deletion binding
B0032355biological_processresponse to estradiol
B0032405molecular_functionMutLalpha complex binding
B0033993biological_processresponse to lipid
B0034644biological_processcellular response to UV
B0035035molecular_functionhistone acetyltransferase binding
B0042802molecular_functionidentical protein binding
B0043596cellular_componentnuclear replication fork
B0043626cellular_componentPCNA complex
B0044849biological_processestrous cycle
B0044877molecular_functionprotein-containing complex binding
B0045739biological_processpositive regulation of DNA repair
B0045740biological_processpositive regulation of DNA replication
B0046686biological_processresponse to cadmium ion
B0070062cellular_componentextracellular exosome
B0070182molecular_functionDNA polymerase binding
B0070301biological_processcellular response to hydrogen peroxide
B0070557cellular_componentPCNA-p21 complex
B0071466biological_processcellular response to xenobiotic stimulus
B0071548biological_processresponse to dexamethasone
B0097421biological_processliver regeneration
B1902065biological_processresponse to L-glutamate
B1902990biological_processmitotic telomere maintenance via semi-conservative replication
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0001673cellular_componentmale germ cell nucleus
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003684molecular_functiondamaged DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005652cellular_componentnuclear lamina
C0005654cellular_componentnucleoplasm
C0005657cellular_componentreplication fork
C0005813cellular_componentcentrosome
C0006260biological_processDNA replication
C0006272biological_processleading strand elongation
C0006275biological_processregulation of DNA replication
C0006281biological_processDNA repair
C0006287biological_processbase-excision repair, gap-filling
C0006298biological_processmismatch repair
C0006325biological_processchromatin organization
C0006974biological_processDNA damage response
C0006979biological_processresponse to oxidative stress
C0007507biological_processheart development
C0016604cellular_componentnuclear body
C0019899molecular_functionenzyme binding
C0019985biological_processtranslesion synthesis
C0030331molecular_functionnuclear estrogen receptor binding
C0030337molecular_functionDNA polymerase processivity factor activity
C0030855biological_processepithelial cell differentiation
C0030894cellular_componentreplisome
C0030971molecular_functionreceptor tyrosine kinase binding
C0031297biological_processreplication fork processing
C0032139molecular_functiondinucleotide insertion or deletion binding
C0032355biological_processresponse to estradiol
C0032405molecular_functionMutLalpha complex binding
C0033993biological_processresponse to lipid
C0034644biological_processcellular response to UV
C0035035molecular_functionhistone acetyltransferase binding
C0042802molecular_functionidentical protein binding
C0043596cellular_componentnuclear replication fork
C0043626cellular_componentPCNA complex
C0044849biological_processestrous cycle
C0044877molecular_functionprotein-containing complex binding
C0045739biological_processpositive regulation of DNA repair
C0045740biological_processpositive regulation of DNA replication
C0046686biological_processresponse to cadmium ion
C0070062cellular_componentextracellular exosome
C0070182molecular_functionDNA polymerase binding
C0070301biological_processcellular response to hydrogen peroxide
C0070557cellular_componentPCNA-p21 complex
C0071466biological_processcellular response to xenobiotic stimulus
C0071548biological_processresponse to dexamethasone
C0097421biological_processliver regeneration
C1902065biological_processresponse to L-glutamate
C1902990biological_processmitotic telomere maintenance via semi-conservative replication
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
D0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
D0000781cellular_componentchromosome, telomeric region
D0000785cellular_componentchromatin
D0001673cellular_componentmale germ cell nucleus
D0003677molecular_functionDNA binding
D0003682molecular_functionchromatin binding
D0003684molecular_functiondamaged DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005652cellular_componentnuclear lamina
D0005654cellular_componentnucleoplasm
D0005657cellular_componentreplication fork
D0005813cellular_componentcentrosome
D0006260biological_processDNA replication
D0006272biological_processleading strand elongation
D0006275biological_processregulation of DNA replication
D0006281biological_processDNA repair
D0006287biological_processbase-excision repair, gap-filling
D0006298biological_processmismatch repair
D0006325biological_processchromatin organization
D0006974biological_processDNA damage response
D0006979biological_processresponse to oxidative stress
D0007507biological_processheart development
D0016604cellular_componentnuclear body
D0019899molecular_functionenzyme binding
D0019985biological_processtranslesion synthesis
D0030331molecular_functionnuclear estrogen receptor binding
D0030337molecular_functionDNA polymerase processivity factor activity
D0030855biological_processepithelial cell differentiation
D0030894cellular_componentreplisome
D0030971molecular_functionreceptor tyrosine kinase binding
D0031297biological_processreplication fork processing
D0032139molecular_functiondinucleotide insertion or deletion binding
D0032355biological_processresponse to estradiol
D0032405molecular_functionMutLalpha complex binding
D0033993biological_processresponse to lipid
D0034644biological_processcellular response to UV
D0035035molecular_functionhistone acetyltransferase binding
D0042802molecular_functionidentical protein binding
D0043596cellular_componentnuclear replication fork
D0043626cellular_componentPCNA complex
D0044849biological_processestrous cycle
D0044877molecular_functionprotein-containing complex binding
D0045739biological_processpositive regulation of DNA repair
D0045740biological_processpositive regulation of DNA replication
D0046686biological_processresponse to cadmium ion
D0070062cellular_componentextracellular exosome
D0070182molecular_functionDNA polymerase binding
D0070301biological_processcellular response to hydrogen peroxide
D0070557cellular_componentPCNA-p21 complex
D0071466biological_processcellular response to xenobiotic stimulus
D0071548biological_processresponse to dexamethasone
D0097421biological_processliver regeneration
D1902065biological_processresponse to L-glutamate
D1902990biological_processmitotic telomere maintenance via semi-conservative replication
Functional Information from PROSITE/UniProt
site_idPS00293
Number of Residues19
DetailsPCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL
ChainResidueDetails
BARG61-LEU79
site_idPS01251
Number of Residues24
DetailsPCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF
ChainResidueDetails
BGLY34-PHE57
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues57
DetailsDNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues279
DetailsRegion: {"description":"Interaction with NUDT15","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues9
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsModified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"17115032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38459011","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17108083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17130289","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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