9F44
cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL |
| Chain | Residue | Details |
| C | MET100-LEU114 |
| site_id | PS00915 |
| Number of Residues | 15 |
| Details | PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ |
| Chain | Residue | Details |
| A | LEU2186-GLN2200 |
| site_id | PS00916 |
| Number of Residues | 21 |
| Details | PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN |
| Chain | Residue | Details |
| A | SER2323-ASN2343 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:31530866 |
| Chain | Residue | Details |
| E | SER44 | |
| A | MET2345 | |
| A | ILE2356 | |
| B | SER2165 | |
| B | GLN2167 | |
| B | LEU2185 | |
| B | GLU2190 | |
| B | TYR2225 | |
| B | GLY2238 | |
| B | TRP2239 | |
| B | VAL2240 | |
| E | SER122 | |
| B | THR2245 | |
| B | MET2345 | |
| B | ILE2356 | |
| E | SER836 | |
| E | SER982 | |
| F | SER44 | |
| F | SER122 | |
| F | SER836 | |
| F | SER982 | |
| A | THR2245 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER696 | |
| F | SER696 | |
| A | ASP2357 | |
| B | LYS2187 | |
| B | ASN2343 | |
| B | ASP2357 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:31530866 |
| Chain | Residue | Details |
| E | THR706 | |
| F | THR706 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by RPS6KA1 => ECO:0000269|PubMed:18722121, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER719 | |
| F | SER719 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by RPS6KA1 => ECO:0000269|PubMed:18722121 |
| Chain | Residue | Details |
| E | SER721 | |
| F | SER721 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by AMPK and RPS6KA1 => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:37541260, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER722 | |
| F | SER722 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER738 | |
| F | SER738 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31112131 |
| Chain | Residue | Details |
| E | SER791 | |
| F | SER791 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| E | SER792 | |
| F | SER792 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19864431 |
| Chain | Residue | Details |
| E | SER855 | |
| F | SER855 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER859 | |
| F | SER859 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8, MTOR and NLK => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER863 | |
| F | SER863 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | THR865 | |
| F | THR865 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER877 | |
| F | SER877 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715 |
| Chain | Residue | Details |
| E | LYS1097 | |
| F | LYS1097 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| E | THR700 | |
| F | THR700 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303 |
| Chain | Residue | Details |
| E | LYS932 | |
| E | LYS948 | |
| F | LYS932 | |
| F | LYS948 |
