9F2Y
Focused refinement of SV2B-LD-BoNT/A1 at pH 5.5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001669 | cellular_component | acrosomal vesicle |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0099509 | biological_process | regulation of presynaptic cytosolic calcium ion concentration |
| A | 2000300 | biological_process | regulation of synaptic vesicle exocytosis |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008320 | molecular_function | protein transmembrane transporter activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| B | 0044164 | cellular_component | host cell cytosol |
| B | 0044231 | cellular_component | host cell presynaptic membrane |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071806 | biological_process | protein transmembrane transport |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PROSITE/UniProt
| site_id | PS00216 |
| Number of Residues | 17 |
| Details | SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. LGGLADKLGRKrvlsm.S |
| Chain | Residue | Details |
| A | LEU165-SER181 |
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. IsGIGiGGalpivfaYfsEflsrekR |
| Chain | Residue | Details |
| A | ILE207-ARG232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 221 |
| Details | Region: {"description":"N-terminus of receptor binding domain (N-RBD)","evidences":[{"source":"PubMed","id":"19096517","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Region: {"description":"Interaction with host ganglioside GT1b","evidences":[{"source":"PubMed","id":"18704164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27958736","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14731268","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10694409","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15592454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19351593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XTF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15592454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19351593","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7578132","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1XTF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15592454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19351593","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11700044","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1XTF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18704164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27958736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18704164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27958736","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14731268","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"11827515","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
