9EWY
CryoEM structure of human MICAL1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003779 | molecular_function | actin binding |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005882 | cellular_component | intermediate filament |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007010 | biological_process | cytoskeleton organization |
| A | 0007165 | biological_process | signal transduction |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
| A | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| A | 0017124 | molecular_function | SH3 domain binding |
| A | 0019417 | biological_process | sulfur oxidation |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030042 | biological_process | actin filament depolymerization |
| A | 0030496 | cellular_component | midbody |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045171 | cellular_component | intercellular bridge |
| A | 0051015 | molecular_function | actin filament binding |
| A | 0051017 | biological_process | actin filament bundle assembly |
| A | 0071949 | molecular_function | FAD binding |
| A | 0120501 | molecular_function | F-actin monooxygenase activity |
| A | 1903305 | biological_process | regulation of regulated secretory pathway |
| A | 1990026 | cellular_component | hippocampal mossy fiber expansion |
Functional Information from PROSITE/UniProt
| site_id | PS00478 |
| Number of Residues | 35 |
| Details | LIM_DOMAIN_1 LIM zinc-binding domain signature. CalCgehlyvlerlcvnghf.....FHrsCfrChtCeatL |
| Chain | Residue | Details |
| A | CYS697-LEU731 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 104 |
| Details | Domain: {"description":"Calponin-homology (CH)","evidences":[{"source":"PROSITE-ProRule","id":"PRU00044","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 71 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8VDP3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2CO8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"D3ZBP4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
