9EVH

SV40 large T antigen assembly with DNA in presence of ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003688	molecular_function	DNA replication origin binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
A	0039576	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
A	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
A	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
A	0039686	biological_process	bidirectional double-stranded viral DNA replication
A	0039693	biological_process	viral DNA genome replication
A	0042025	cellular_component	host cell nucleus
A	0042802	molecular_function	identical protein binding
A	0044071	biological_process	symbiont-mediated perturbation of host cell cycle progression
A	0046872	molecular_function	metal ion binding
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003688	molecular_function	DNA replication origin binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
B	0039576	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
B	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
B	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
B	0039686	biological_process	bidirectional double-stranded viral DNA replication
B	0039693	biological_process	viral DNA genome replication
B	0042025	cellular_component	host cell nucleus
B	0042802	molecular_function	identical protein binding
B	0044071	biological_process	symbiont-mediated perturbation of host cell cycle progression
B	0046872	molecular_function	metal ion binding
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003688	molecular_function	DNA replication origin binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006260	biological_process	DNA replication
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
C	0039576	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
C	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
C	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
C	0039686	biological_process	bidirectional double-stranded viral DNA replication
C	0039693	biological_process	viral DNA genome replication
C	0042025	cellular_component	host cell nucleus
C	0042802	molecular_function	identical protein binding
C	0044071	biological_process	symbiont-mediated perturbation of host cell cycle progression
C	0046872	molecular_function	metal ion binding
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006260	biological_process	DNA replication
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
D	0039576	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
D	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
D	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
D	0039686	biological_process	bidirectional double-stranded viral DNA replication
D	0039693	biological_process	viral DNA genome replication
D	0042025	cellular_component	host cell nucleus
D	0042802	molecular_function	identical protein binding
D	0044071	biological_process	symbiont-mediated perturbation of host cell cycle progression
D	0046872	molecular_function	metal ion binding
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003688	molecular_function	DNA replication origin binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006260	biological_process	DNA replication
E	0008270	molecular_function	zinc ion binding
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039576	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
E	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
E	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
E	0039686	biological_process	bidirectional double-stranded viral DNA replication
E	0039693	biological_process	viral DNA genome replication
E	0042025	cellular_component	host cell nucleus
E	0042802	molecular_function	identical protein binding
E	0044071	biological_process	symbiont-mediated perturbation of host cell cycle progression
E	0046872	molecular_function	metal ion binding
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003688	molecular_function	DNA replication origin binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0006260	biological_process	DNA replication
F	0008270	molecular_function	zinc ion binding
F	0016787	molecular_function	hydrolase activity
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
F	0039576	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
F	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
F	0039648	biological_process	symbiont-mediated perturbation of host ubiquitin-like protein modification
F	0039686	biological_process	bidirectional double-stranded viral DNA replication
F	0039693	biological_process	viral DNA genome replication
F	0042025	cellular_component	host cell nucleus
F	0042802	molecular_function	identical protein binding
F	0044071	biological_process	symbiont-mediated perturbation of host cell cycle progression
F	0046872	molecular_function	metal ion binding
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	690
Details	DNA_BIND: T-ag OBD => ECO:0000255|PROSITE-ProRule:PRU00620

Chain	Residue	Details
A	PRO139-GLU254
B	PRO139-GLU254
C	PRO139-GLU254
D	PRO139-GLU254
E	PRO139-GLU254
F	PRO139-GLU254

---

site_id	SWS_FT_FI2
Number of Residues	552
Details	ZN_FING: T-ag D1-type => ECO:0000255|PROSITE-ProRule:PRU00671

Chain	Residue	Details
A	THR265-ARG357
B	THR265-ARG357
C	THR265-ARG357
D	THR265-ARG357
E	THR265-ARG357
F	THR265-ARG357

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00671

Chain	Residue	Details
A	CYS302
C	CYS305
C	HIS313
C	HIS317
D	CYS302
D	CYS305
D	HIS313
D	HIS317
E	CYS302
E	CYS305
E	HIS313
A	CYS305
E	HIS317
F	CYS302
F	CYS305
F	HIS313
F	HIS317
A	HIS313
A	HIS317
B	CYS302
B	CYS305
B	HIS313
B	HIS317
C	CYS302

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00551

Chain	Residue	Details
A	GLY426
B	GLY426
C	GLY426
D	GLY426
E	GLY426
F	GLY426

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N-acetylmethionine; by host => ECO:0000269|PubMed:205802

Chain	Residue	Details
A	MET1
B	MET1
C	MET1
D	MET1
E	MET1
F	MET1

---

site_id	SWS_FT_FI6
Number of Residues	30
Details	MOD_RES: Phosphoserine; by host => ECO:0000269|PubMed:2160857, ECO:0000269|PubMed:2838952

Chain	Residue	Details
A	SER106
B	SER679
C	SER106
C	SER112
C	SER123
C	SER677
C	SER679
D	SER106
D	SER112
D	SER123
D	SER677
A	SER112
D	SER679
E	SER106
E	SER112
E	SER123
E	SER677
E	SER679
F	SER106
F	SER112
F	SER123
F	SER677
A	SER123
F	SER679
A	SER677
A	SER679
B	SER106
B	SER112
B	SER123
B	SER677

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphoserine; by host => ECO:0000269|PubMed:2160857

Chain	Residue	Details
A	SER120
E	SER639
F	SER120
F	SER639
A	SER639
B	SER120
B	SER639
C	SER120
C	SER639
D	SER120
D	SER639
E	SER120

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by host => ECO:0000269|PubMed:2160857, ECO:0000269|PubMed:2552322, ECO:0000269|PubMed:2838952, ECO:0000269|PubMed:8648725

Chain	Residue	Details
A	THR124
B	THR124
C	THR124
D	THR124
E	THR124
F	THR124

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphoserine; by host => ECO:0000269|PubMed:2838952

Chain	Residue	Details
A	SER676
B	SER676
C	SER676
D	SER676
E	SER676
F	SER676

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000269|PubMed:15254196

Chain	Residue	Details
A	LYS697
B	LYS697
C	LYS697
D	LYS697
E	LYS697
F	LYS697

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by host => ECO:0000269|PubMed:2160857, ECO:0000269|PubMed:2838952

Chain	Residue	Details
A	THR701
B	THR701
C	THR701
D	THR701
E	THR701
F	THR701

---