9EOF

Structure of the human INTS5/8/10/15 subcomplex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0001654	biological_process	eye development
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0007420	biological_process	brain development
C	0032039	cellular_component	integrator complex
C	0160232	cellular_component	INTAC complex
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0016180	biological_process	snRNA processing
D	0032039	cellular_component	integrator complex
D	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
D	0160232	cellular_component	INTAC complex
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
F	0000785	cellular_component	chromatin
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0016180	biological_process	snRNA processing
F	0032039	cellular_component	integrator complex
F	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
F	0034472	biological_process	snRNA 3'-end processing
F	0071168	biological_process	protein localization to chromatin
F	0160232	cellular_component	INTAC complex
F	0160240	biological_process	RNA polymerase II transcription initiation surveillance
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0016020	cellular_component	membrane
G	0016180	biological_process	snRNA processing
G	0031965	cellular_component	nuclear membrane
G	0032039	cellular_component	integrator complex
G	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
G	0034472	biological_process	snRNA 3'-end processing
G	0160232	cellular_component	INTAC complex
G	0160240	biological_process	RNA polymerase II transcription initiation surveillance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	38
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	33
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	33
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	5
Details	Motif: {"description":"WFEF motif","evidences":[{"source":"PubMed","id":"32966759","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	60
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---