9EKW

Apo TRPML2 in a closed state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005381	molecular_function	iron ion transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005765	cellular_component	lysosomal membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0019722	biological_process	calcium-mediated signaling
A	0031902	cellular_component	late endosome membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034755	biological_process	iron ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0045087	biological_process	innate immune response
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0070588	biological_process	calcium ion transmembrane transport
A	0072345	molecular_function	NAADP-sensitive calcium-release channel activity
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005381	molecular_function	iron ion transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0019722	biological_process	calcium-mediated signaling
B	0031902	cellular_component	late endosome membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034755	biological_process	iron ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0045087	biological_process	innate immune response
B	0055037	cellular_component	recycling endosome
B	0055038	cellular_component	recycling endosome membrane
B	0070588	biological_process	calcium ion transmembrane transport
B	0072345	molecular_function	NAADP-sensitive calcium-release channel activity
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005381	molecular_function	iron ion transmembrane transporter activity
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0019722	biological_process	calcium-mediated signaling
C	0031902	cellular_component	late endosome membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034755	biological_process	iron ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0045087	biological_process	innate immune response
C	0055037	cellular_component	recycling endosome
C	0055038	cellular_component	recycling endosome membrane
C	0070588	biological_process	calcium ion transmembrane transport
C	0072345	molecular_function	NAADP-sensitive calcium-release channel activity
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005381	molecular_function	iron ion transmembrane transporter activity
D	0005515	molecular_function	protein binding
D	0005765	cellular_component	lysosomal membrane
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0019722	biological_process	calcium-mediated signaling
D	0031902	cellular_component	late endosome membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034755	biological_process	iron ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0045087	biological_process	innate immune response
D	0055037	cellular_component	recycling endosome
D	0055038	cellular_component	recycling endosome membrane
D	0070588	biological_process	calcium ion transmembrane transport
D	0072345	molecular_function	NAADP-sensitive calcium-release channel activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	484
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	100
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	Region: {"description":"Extracellular/lumenal pore loop","evidences":[{"source":"UniProtKB","id":"Q9GZU1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---