9EJL
Lgl2 bound to the aPKCiota-Par6B complex in nucleotide-free form. Conformation with visible head sub-complex.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005912 | cellular_component | adherens junction |
| A | 0006887 | biological_process | exocytosis |
| A | 0006893 | biological_process | Golgi to plasma membrane transport |
| A | 0008593 | biological_process | regulation of Notch signaling pathway |
| A | 0015820 | biological_process | L-leucine transport |
| A | 0030165 | molecular_function | PDZ domain binding |
| A | 0030864 | cellular_component | cortical actin cytoskeleton |
| A | 0030866 | biological_process | cortical actin cytoskeleton organization |
| A | 0032878 | biological_process | regulation of establishment or maintenance of cell polarity |
| A | 0045159 | molecular_function | myosin II binding |
| A | 0045197 | biological_process | establishment or maintenance of epithelial cell apical/basal polarity |
| A | 0051294 | biological_process | establishment of spindle orientation |
| A | 0051301 | biological_process | cell division |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004697 | molecular_function | diacylglycerol-dependent serine/threonine kinase activity |
| B | 0004699 | molecular_function | diacylglycerol-dependent, calcium-independent serine/threonine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005768 | cellular_component | endosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005903 | cellular_component | brush border |
| B | 0005923 | cellular_component | bicellular tight junction |
| B | 0005929 | cellular_component | cilium |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006612 | biological_process | protein targeting to membrane |
| B | 0007010 | biological_process | cytoskeleton organization |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0010976 | biological_process | positive regulation of neuron projection development |
| B | 0016020 | cellular_component | membrane |
| B | 0016192 | biological_process | vesicle-mediated transport |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016477 | biological_process | cell migration |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030010 | biological_process | establishment of cell polarity |
| B | 0031252 | cellular_component | cell leading edge |
| B | 0032869 | biological_process | cellular response to insulin stimulus |
| B | 0034351 | biological_process | negative regulation of glial cell apoptotic process |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0043220 | cellular_component | Schmidt-Lanterman incisure |
| B | 0043434 | biological_process | response to peptide hormone |
| B | 0043524 | biological_process | negative regulation of neuron apoptotic process |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0045197 | biological_process | establishment or maintenance of epithelial cell apical/basal polarity |
| B | 0045216 | biological_process | cell-cell junction organization |
| B | 0045747 | biological_process | positive regulation of Notch signaling pathway |
| B | 0046326 | biological_process | positive regulation of D-glucose import |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046903 | biological_process | secretion |
| B | 0048194 | biological_process | Golgi vesicle budding |
| B | 0051092 | biological_process | positive regulation of NF-kappaB transcription factor activity |
| B | 0060252 | biological_process | positive regulation of glial cell proliferation |
| B | 0061024 | biological_process | membrane organization |
| B | 0062197 | biological_process | cellular response to chemical stress |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070160 | cellular_component | tight junction |
| B | 0070555 | biological_process | response to interleukin-1 |
| B | 0072659 | biological_process | protein localization to plasma membrane |
| B | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099072 | biological_process | regulation of postsynaptic membrane neurotransmitter receptor levels |
| B | 0106310 | molecular_function | protein serine kinase activity |
| B | 1903078 | biological_process | positive regulation of protein localization to plasma membrane |
| B | 2000353 | biological_process | positive regulation of endothelial cell apoptotic process |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005923 | cellular_component | bicellular tight junction |
| C | 0005938 | cellular_component | cell cortex |
| C | 0007098 | biological_process | centrosome cycle |
| C | 0007163 | biological_process | establishment or maintenance of cell polarity |
| C | 0016324 | cellular_component | apical plasma membrane |
| C | 0030054 | cellular_component | cell junction |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0045177 | cellular_component | apical part of cell |
| C | 0051301 | biological_process | cell division |
| C | 0060341 | biological_process | regulation of cellular localization |
| C | 0065003 | biological_process | protein-containing complex assembly |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 28 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGSYAKVLlVrlkktdriyamk......VVKK |
| Chain | Residue | Details |
| B | ILE260-LYS287 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKldNVLL |
| Chain | Residue | Details |
| B | ILE374-LEU386 |
| site_id | PS00479 |
| Number of Residues | 50 |
| Details | ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HtFqakrfnrrah.CaiCtdrIwglgrqgyk.CinCkllvHkkChklvtie..C |
| Chain | Residue | Details |
| B | HIS141-CYS190 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLTGheDgTVRFWDA |
| Chain | Residue | Details |
| A | LEU438-ALA452 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"WD 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 75 |
| Details | Repeat: {"description":"WD 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 61 |
| Details | Repeat: {"description":"WD 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 56 |
| Details | Repeat: {"description":"WD 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"WD 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 53 |
| Details | Repeat: {"description":"WD 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"WD 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12725730","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 163 |
| Details | Domain: {"description":"PB1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 50 |
| Details | Zinc finger: {"description":"Phorbol-ester/DAG-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 19 |
| Details | Region: {"description":"Interaction with PARD6A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Pseudosubstrate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"11713277","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11891849","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"11713277","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"16125198","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16125198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 756 |
| Chain | Residue | Details |
| B | ASP378 | proton shuttle (general acid/base) |
| B | LYS380 | electrostatic stabiliser |
| B | ASN383 | electrostatic stabiliser |
