9EIO
Cryo-EM structure of the mutant KCa2.2_F244S channel
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
| Chain | Residue | Details |
| E | ASP20-LEU32 | |
| E | ASP56-PHE68 | |
| E | ASP93-LEU105 | |
| E | ASP129-PHE141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:11323678, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1G4Y, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3B32, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3IFK, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4G27, ECO:0007744|PDB:4G28, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4J9Y, ECO:0007744|PDB:4J9Z, ECO:0007744|PDB:4QNH |
| Chain | Residue | Details |
| E | ASP20 | |
| F | GLU31 | |
| G | ASP20 | |
| G | ASP22 | |
| G | ASP24 | |
| G | THR26 | |
| G | GLU31 | |
| H | ASP20 | |
| H | ASP22 | |
| H | ASP24 | |
| H | THR26 | |
| E | ASP22 | |
| H | GLU31 | |
| E | ASP24 | |
| E | THR26 | |
| E | GLU31 | |
| F | ASP20 | |
| F | ASP22 | |
| F | ASP24 | |
| F | THR26 |
| Chain | Residue | Details |
| E | ASP56 | |
| F | GLU67 | |
| G | ASP56 | |
| G | ASP58 | |
| G | ASN60 | |
| G | THR62 | |
| G | GLU67 | |
| H | ASP56 | |
| H | ASP58 | |
| H | ASN60 | |
| H | THR62 | |
| E | ASP58 | |
| H | GLU67 | |
| E | ASN60 | |
| E | THR62 | |
| E | GLU67 | |
| F | ASP56 | |
| F | ASP58 | |
| F | ASN60 | |
| F | THR62 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK4, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG6, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4RJD |
| Chain | Residue | Details |
| E | ASP93 | |
| F | GLU104 | |
| G | ASP93 | |
| G | ASP95 | |
| G | ASN97 | |
| G | TYR99 | |
| G | GLU104 | |
| H | ASP93 | |
| H | ASP95 | |
| H | ASN97 | |
| H | TYR99 | |
| E | ASP95 | |
| H | GLU104 | |
| E | ASN97 | |
| E | TYR99 | |
| E | GLU104 | |
| F | ASP93 | |
| F | ASP95 | |
| F | ASN97 | |
| F | TYR99 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4RJD |
| Chain | Residue | Details |
| E | ASP129 | |
| F | GLU140 | |
| G | ASP129 | |
| G | ASP131 | |
| G | ASP133 | |
| G | GLN135 | |
| G | GLU140 | |
| H | ASP129 | |
| H | ASP131 | |
| H | ASP133 | |
| H | GLN135 | |
| E | ASP131 | |
| H | GLU140 | |
| E | ASP133 | |
| E | GLN135 | |
| E | GLU140 | |
| F | ASP129 | |
| F | ASP131 | |
| F | ASP133 | |
| F | GLN135 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| E | LYS21 | |
| F | LYS21 | |
| G | LYS21 | |
| H | LYS21 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000269|PubMed:12392717 |
| Chain | Residue | Details |
| E | THR44 | |
| F | THR44 | |
| G | THR44 | |
| H | THR44 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| E | SER81 | |
| F | SER81 | |
| G | SER81 | |
| H | SER81 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| E | LYS94 | |
| F | LYS94 | |
| G | LYS94 | |
| H | LYS94 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| E | TYR99 | |
| F | TYR99 | |
| G | TYR99 | |
| H | TYR99 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| E | SER101 | |
| F | SER101 | |
| G | SER101 | |
| H | SER101 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| E | THR110 | |
| F | THR110 | |
| G | THR110 | |
| H | THR110 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| E | LYS115 | |
| F | LYS115 | |
| G | LYS115 | |
| H | LYS115 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| E | TYR138 | |
| F | TYR138 | |
| G | TYR138 | |
| H | TYR138 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157 |
| Chain | Residue | Details |
| E | LYS21 | |
| F | LYS21 | |
| G | LYS21 | |
| H | LYS21 |
