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9EII

Import stalled PINK1 TOM complex, symmetry expanded

Functional Information from GO Data
ChainGOidnamespacecontents
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0000422biological_processautophagy of mitochondrion
B0000423biological_processmitophagy
B0000785cellular_componentchromatin
B0002020molecular_functionprotease binding
B0002082biological_processregulation of oxidative phosphorylation
B0002931biological_processresponse to ischemia
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005743cellular_componentmitochondrial inner membrane
B0005758cellular_componentmitochondrial intermembrane space
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006468biological_processprotein phosphorylation
B0006511biological_processubiquitin-dependent protein catabolic process
B0006914biological_processautophagy
B0006950biological_processresponse to stress
B0006979biological_processresponse to oxidative stress
B0007005biological_processmitochondrion organization
B0010310biological_processregulation of hydrogen peroxide metabolic process
B0010629biological_processnegative regulation of gene expression
B0010821biological_processregulation of mitochondrion organization
B0014046biological_processdopamine secretion
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016239biological_processpositive regulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016301molecular_functionkinase activity
B0016504molecular_functionpeptidase activator activity
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0019900molecular_functionkinase binding
B0022904biological_processrespiratory electron transport chain
B0030097biological_processhemopoiesis
B0030335biological_processpositive regulation of cell migration
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0031396biological_processregulation of protein ubiquitination
B0031398biological_processpositive regulation of protein ubiquitination
B0031625molecular_functionubiquitin protein ligase binding
B0032226biological_processpositive regulation of synaptic transmission, dopaminergic
B0033603biological_processpositive regulation of dopamine secretion
B0033605biological_processpositive regulation of catecholamine secretion
B0034599biological_processcellular response to oxidative stress
B0035556biological_processintracellular signal transduction
B0038203biological_processTORC2 signaling
B0042981biological_processregulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043254biological_processregulation of protein-containing complex assembly
B0043422molecular_functionprotein kinase B binding
B0043523biological_processregulation of neuron apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045727biological_processpositive regulation of translation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046329biological_processnegative regulation of JNK cascade
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050432biological_processcatecholamine secretion
B0050821biological_processprotein stabilization
B0051649biological_processestablishment of localization in cell
B0051881biological_processregulation of mitochondrial membrane potential
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055131molecular_functionC3HC4-type RING finger domain binding
B0061136biological_processregulation of proteasomal protein catabolic process
B0071456biological_processcellular response to hypoxia
B0072655biological_processestablishment of protein localization to mitochondrion
B0072656biological_processmaintenance of protein location in mitochondrion
B0090141biological_processpositive regulation of mitochondrial fission
B0090200biological_processpositive regulation of release of cytochrome c from mitochondria
B0090258biological_processnegative regulation of mitochondrial fission
B0097237biological_processcellular response to toxic substance
B0097413cellular_componentLewy body
B0097449cellular_componentastrocyte projection
B0099074biological_processmitochondrion to lysosome vesicle-mediated transport
B0106310molecular_functionprotein serine kinase activity
B1900407biological_processregulation of cellular response to oxidative stress
B1901525biological_processnegative regulation of mitophagy
B1902803biological_processregulation of synaptic vesicle transport
B1902902biological_processnegative regulation of autophagosome assembly
B1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
B1903146biological_processregulation of autophagy of mitochondrion
B1903214biological_processregulation of protein targeting to mitochondrion
B1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
B1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
B1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
B1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
B1903852biological_processpositive regulation of cristae formation
B1903955biological_processpositive regulation of protein targeting to mitochondrion
B1904544biological_processpositive regulation of free ubiquitin chain polymerization
B1904881biological_processcellular response to hydrogen sulfide
B1905091biological_processpositive regulation of type 2 mitophagy
B2000377biological_processregulation of reactive oxygen species metabolic process
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
B2001171biological_processpositive regulation of ATP biosynthetic process
B2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005740cellular_componentmitochondrial envelope
D0005741cellular_componentmitochondrial outer membrane
D0005742cellular_componentmitochondrial outer membrane translocase complex
D0006626biological_processprotein targeting to mitochondrion
D0008320molecular_functionprotein transmembrane transporter activity
D0015031biological_processprotein transport
D0015450molecular_functionprotein-transporting ATPase activity
D0016020cellular_componentmembrane
D0016031biological_processtRNA import into mitochondrion
D0030150biological_processprotein import into mitochondrial matrix
D0030943molecular_functionmitochondrion targeting sequence binding
D0044233cellular_componentmitochondria-associated endoplasmic reticulum membrane contact site
D0045040biological_processprotein insertion into mitochondrial outer membrane
D0051082molecular_functionunfolded protein binding
D0071944cellular_componentcell periphery
D0097225cellular_componentsperm midpiece
D0140494cellular_componentmigrasome
D0140596cellular_componentTOM complex
F0000166molecular_functionnucleotide binding
F0001669cellular_componentacrosomal vesicle
F0005244molecular_functionvoltage-gated monoatomic ion channel activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005739cellular_componentmitochondrion
F0005741cellular_componentmitochondrial outer membrane
F0006811biological_processmonoatomic ion transport
F0006820biological_processmonoatomic anion transport
F0006869biological_processlipid transport
F0007339biological_processbinding of sperm to zona pellucida
F0008142molecular_functionoxysterol binding
F0008289molecular_functionlipid binding
F0008308molecular_functionvoltage-gated monoatomic anion channel activity
F0015288molecular_functionporin activity
F0015485molecular_functioncholesterol binding
F0016020cellular_componentmembrane
F0017121biological_processplasma membrane phospholipid scrambling
F0017128molecular_functionphospholipid scramblase activity
F0031210molecular_functionphosphatidylcholine binding
F0031966cellular_componentmitochondrial membrane
F0042645cellular_componentmitochondrial nucleoid
F0045332biological_processphospholipid translocation
F0046930cellular_componentpore complex
F0097001molecular_functionceramide binding
F0097225cellular_componentsperm midpiece
F0097345biological_processmitochondrial outer membrane permeabilization
F1990542biological_processmitochondrial transmembrane transport
I0005515molecular_functionprotein binding
I0005739cellular_componentmitochondrion
I0005741cellular_componentmitochondrial outer membrane
I0005742cellular_componentmitochondrial outer membrane translocase complex
I0005743cellular_componentmitochondrial inner membrane
I0005829cellular_componentcytosol
I0006626biological_processprotein targeting to mitochondrion
I0006811biological_processmonoatomic ion transport
I0008320molecular_functionprotein transmembrane transporter activity
I0015031biological_processprotein transport
I0015288molecular_functionporin activity
I0016020cellular_componentmembrane
I0030150biological_processprotein import into mitochondrial matrix
I0044233cellular_componentmitochondria-associated endoplasmic reticulum membrane contact site
I0045040biological_processprotein insertion into mitochondrial outer membrane
I0046930cellular_componentpore complex
I0140596cellular_componentTOM complex
J0005515molecular_functionprotein binding
J0005739cellular_componentmitochondrion
J0005741cellular_componentmitochondrial outer membrane
J0005742cellular_componentmitochondrial outer membrane translocase complex
J0005743cellular_componentmitochondrial inner membrane
J0005829cellular_componentcytosol
J0006626biological_processprotein targeting to mitochondrion
J0006811biological_processmonoatomic ion transport
J0008320molecular_functionprotein transmembrane transporter activity
J0015031biological_processprotein transport
J0015288molecular_functionporin activity
J0016020cellular_componentmembrane
J0030150biological_processprotein import into mitochondrial matrix
J0044233cellular_componentmitochondria-associated endoplasmic reticulum membrane contact site
J0045040biological_processprotein insertion into mitochondrial outer membrane
J0046930cellular_componentpore complex
J0140596cellular_componentTOM complex
L0005739cellular_componentmitochondrion
L0005741cellular_componentmitochondrial outer membrane
L0005742cellular_componentmitochondrial outer membrane translocase complex
L0006626biological_processprotein targeting to mitochondrion
L0015031biological_processprotein transport
L0016020cellular_componentmembrane
L0045040biological_processprotein insertion into mitochondrial outer membrane
L0140596cellular_componentTOM complex
N0005515molecular_functionprotein binding
N0005739cellular_componentmitochondrion
N0005741cellular_componentmitochondrial outer membrane
N0005742cellular_componentmitochondrial outer membrane translocase complex
N0008320molecular_functionprotein transmembrane transporter activity
N0015031biological_processprotein transport
N0016020cellular_componentmembrane
N0030150biological_processprotein import into mitochondrial matrix
N0031647biological_processregulation of protein stability
N0045040biological_processprotein insertion into mitochondrial outer membrane
N0140596cellular_componentTOM complex
N1903955biological_processpositive regulation of protein targeting to mitochondrion
N1905091biological_processpositive regulation of type 2 mitophagy
P0005515molecular_functionprotein binding
P0005739cellular_componentmitochondrion
P0005741cellular_componentmitochondrial outer membrane
P0015031biological_processprotein transport
P0016020cellular_componentmembrane
P0045040biological_processprotein insertion into mitochondrial outer membrane
P0140596cellular_componentTOM complex
R0005515molecular_functionprotein binding
R0005739cellular_componentmitochondrion
R0005741cellular_componentmitochondrial outer membrane
R0005742cellular_componentmitochondrial outer membrane translocase complex
R0006626biological_processprotein targeting to mitochondrion
R0008320molecular_functionprotein transmembrane transporter activity
R0015031biological_processprotein transport
R0016020cellular_componentmembrane
R0030150biological_processprotein import into mitochondrial matrix
R0030943molecular_functionmitochondrion targeting sequence binding
R0045040biological_processprotein insertion into mitochondrial outer membrane
R0140596cellular_componentTOM complex
T0005515molecular_functionprotein binding
T0005739cellular_componentmitochondrion
T0005741cellular_componentmitochondrial outer membrane
T0005742cellular_componentmitochondrial outer membrane translocase complex
T0006626biological_processprotein targeting to mitochondrion
T0008320molecular_functionprotein transmembrane transporter activity
T0015031biological_processprotein transport
T0016020cellular_componentmembrane
T0030150biological_processprotein import into mitochondrial matrix
T0030943molecular_functionmitochondrion targeting sequence binding
T0045040biological_processprotein insertion into mitochondrial outer membrane
T0140596cellular_componentTOM complex
V0005515molecular_functionprotein binding
V0005739cellular_componentmitochondrion
V0005741cellular_componentmitochondrial outer membrane
V0015031biological_processprotein transport
V0016020cellular_componentmembrane
V0045040biological_processprotein insertion into mitochondrial outer membrane
V0140596cellular_componentTOM complex
X0005515molecular_functionprotein binding
X0005739cellular_componentmitochondrion
X0005741cellular_componentmitochondrial outer membrane
X0005742cellular_componentmitochondrial outer membrane translocase complex
X0008320molecular_functionprotein transmembrane transporter activity
X0015031biological_processprotein transport
X0016020cellular_componentmembrane
X0030150biological_processprotein import into mitochondrial matrix
X0031647biological_processregulation of protein stability
X0045040biological_processprotein insertion into mitochondrial outer membrane
X0140596cellular_componentTOM complex
X1903955biological_processpositive regulation of protein targeting to mitochondrion
X1905091biological_processpositive regulation of type 2 mitophagy
Z0005739cellular_componentmitochondrion
Z0005741cellular_componentmitochondrial outer membrane
Z0005742cellular_componentmitochondrial outer membrane translocase complex
Z0006626biological_processprotein targeting to mitochondrion
Z0015031biological_processprotein transport
Z0016020cellular_componentmembrane
Z0045040biological_processprotein insertion into mitochondrial outer membrane
Z0140596cellular_componentTOM complex
Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKsdNILV
ChainResidueDetails
BILE358-VAL370

site_idPS00558
Number of Residues23
DetailsEUKARYOTIC_PORIN Eukaryotic mitochondrial porin signature. YqlDPtAsisAKVNNssliGVgY
ChainResidueDetails
FTYR236-TYR258

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues162
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RALA2-ALA83
FLEU161-ASP169
FLYS174-THR186
FPHE189-ASN196
FGLU200-VAL209
FLEU213-THR222
FARG229-LEU238
FALA242-ASN249
FLEU253-LEU262
FGLY265-VAL274
FHIS284-GLU293
TALA2-ALA83
FVAL65-TRP75
FLEU80-ASN87
FTHR91-ASP100
FLEU106-SER115
FSER122-ARG131
FILE134-ASP141
FALA148-GLY156

site_idSWS_FT_FI2
Number of Residues38
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
RALA84-THR103
TALA84-THR103

site_idSWS_FT_FI3
Number of Residues76
DetailsTOPO_DOM: Mitochondrial intermembrane => ECO:0000255
ChainResidueDetails
RGLU104-ILE142
TGLU104-ILE142
ZLYS10

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712
ChainResidueDetails
RALA2
TALA2

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
RSER15
TSER15

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
RTHR43
TTHR43

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CPQ3
ChainResidueDetails
RSER45
TSER45

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P21796
ChainResidueDetails
FTHR118
DLYS61

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60930
ChainResidueDetails
FLYS120

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21796
ChainResidueDetails
FSER251

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P21796
ChainResidueDetails
FLYS277

site_idSWS_FT_FI12
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:25621951
ChainResidueDetails
FLYS31
FLYS120
FLYS277

site_idSWS_FT_FI13
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25621951
ChainResidueDetails
FLYS64
FLYS72
FLYS121
FLYS124
FLYS285

site_idSWS_FT_FI14
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P21796
ChainResidueDetails
FLYS172

237992

PDB entries from 2025-06-25

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