9EI2

Cryo-EM structure of Human RNA polymerase II Elongation Complex bound to an apo RECQL5 helicase (RECQL5 IRI Module focused-classified)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0000974	cellular_component	Prp19 complex
A	0001172	biological_process	RNA-templated transcription
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005665	cellular_component	RNA polymerase II, core complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006353	biological_process	DNA-templated transcription termination
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0008270	molecular_function	zinc ion binding
A	0010628	biological_process	positive regulation of gene expression
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0019900	molecular_function	kinase binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0033120	biological_process	positive regulation of RNA splicing
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding
A	0050436	molecular_function	microfibril binding
A	1990841	molecular_function	promoter-specific chromatin binding
U	0000166	molecular_function	nucleotide binding
U	0000278	biological_process	mitotic cell cycle
U	0000724	biological_process	double-strand break repair via homologous recombination
U	0000993	molecular_function	RNA polymerase II complex binding
U	0003677	molecular_function	DNA binding
U	0003678	molecular_function	DNA helicase activity
U	0004386	molecular_function	helicase activity
U	0005524	molecular_function	ATP binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005657	cellular_component	replication fork
U	0005694	cellular_component	chromosome
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006259	biological_process	DNA metabolic process
U	0006260	biological_process	DNA replication
U	0006281	biological_process	DNA repair
U	0006974	biological_process	DNA damage response
U	0009378	molecular_function	four-way junction helicase activity
U	0010605	biological_process	negative regulation of macromolecule metabolic process
U	0016787	molecular_function	hydrolase activity
U	0016853	molecular_function	isomerase activity
U	0016887	molecular_function	ATP hydrolysis activity
U	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
U	0043138	molecular_function	3'-5' DNA helicase activity
U	0045934	biological_process	negative regulation of nucleobase-containing compound metabolic process
U	0046872	molecular_function	metal ion binding
U	0051301	biological_process	cell division
U	0051304	biological_process	chromosome separation
U	0071466	biological_process	cellular response to xenobiotic stimulus
U	0072757	biological_process	cellular response to camptothecin
U	0097550	cellular_component	transcription preinitiation complex
U	0140097	molecular_function	catalytic activity, acting on DNA
U	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
U	1990506	biological_process	mitotic DNA-templated DNA replication
U	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1916-LYS1922
A	TYR1629-ASN1635
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

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site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SyLVVDEAHC

Chain	Residue	Details
U	SER152-CYS161

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); by NEDD4","evidences":[{"source":"PubMed","id":"32142649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32142654","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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