Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9EEP

Cryo-EM model of E. coli aspartate transcarbamoylase in the R-state complexed with CP and succinate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006541	biological_process	L-glutamine metabolic process
A	0009347	cellular_component	aspartate carbamoyltransferase complex
A	0042802	molecular_function	identical protein binding
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0070207	biological_process	protein homotrimerization
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006541	biological_process	L-glutamine metabolic process
B	0009347	cellular_component	aspartate carbamoyltransferase complex
B	0042802	molecular_function	identical protein binding
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0070207	biological_process	protein homotrimerization
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006541	biological_process	L-glutamine metabolic process
C	0009347	cellular_component	aspartate carbamoyltransferase complex
C	0042802	molecular_function	identical protein binding
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0070207	biological_process	protein homotrimerization
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0008270	molecular_function	zinc ion binding
D	0009347	cellular_component	aspartate carbamoyltransferase complex
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0008270	molecular_function	zinc ion binding
E	0009347	cellular_component	aspartate carbamoyltransferase complex
F	0004070	molecular_function	aspartate carbamoyltransferase activity
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006541	biological_process	L-glutamine metabolic process
F	0009347	cellular_component	aspartate carbamoyltransferase complex
F	0042802	molecular_function	identical protein binding
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0070207	biological_process	protein homotrimerization
G	0004070	molecular_function	aspartate carbamoyltransferase activity
G	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
G	0006541	biological_process	L-glutamine metabolic process
G	0009347	cellular_component	aspartate carbamoyltransferase complex
G	0042802	molecular_function	identical protein binding
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0070207	biological_process	protein homotrimerization
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0008270	molecular_function	zinc ion binding
H	0009347	cellular_component	aspartate carbamoyltransferase complex
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
I	0006221	biological_process	pyrimidine nucleotide biosynthetic process
I	0008270	molecular_function	zinc ion binding
I	0009347	cellular_component	aspartate carbamoyltransferase complex
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
J	0006221	biological_process	pyrimidine nucleotide biosynthetic process
J	0008270	molecular_function	zinc ion binding
J	0009347	cellular_component	aspartate carbamoyltransferase complex
K	0004070	molecular_function	aspartate carbamoyltransferase activity
K	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
K	0006541	biological_process	L-glutamine metabolic process
K	0009347	cellular_component	aspartate carbamoyltransferase complex
K	0042802	molecular_function	identical protein binding
K	0044205	biological_process	'de novo' UMP biosynthetic process
K	0070207	biological_process	protein homotrimerization
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
L	0006221	biological_process	pyrimidine nucleotide biosynthetic process
L	0008270	molecular_function	zinc ion binding
L	0009347	cellular_component	aspartate carbamoyltransferase complex

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT

Chain	Residue	Details
A	PHE48-THR55

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00001","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3380787","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00001","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3380787","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
A	ARG54	electrostatic stabiliser
A	THR55	electrostatic stabiliser, increase electrophilicity
A	LYS84	proton shuttle (general acid/base)
A	ARG105	electrostatic stabiliser, increase electrophilicity
A	HIS134	electrostatic stabiliser, increase electrophilicity

site_id	MCSA2
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
B	ARG54	electrostatic stabiliser
B	THR55	electrostatic stabiliser, increase electrophilicity
B	LYS84	proton shuttle (general acid/base)
B	ARG105	electrostatic stabiliser, increase electrophilicity
B	HIS134	electrostatic stabiliser, increase electrophilicity

site_id	MCSA3
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
C	ARG54	electrostatic stabiliser
C	THR55	electrostatic stabiliser, increase electrophilicity
C	LYS84	proton shuttle (general acid/base)
C	ARG105	electrostatic stabiliser, increase electrophilicity
C	HIS134	electrostatic stabiliser, increase electrophilicity

site_id	MCSA4
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
F	ARG54	electrostatic stabiliser
F	THR55	electrostatic stabiliser, increase electrophilicity
F	LYS84	proton shuttle (general acid/base)
F	ARG105	electrostatic stabiliser, increase electrophilicity
F	HIS134	electrostatic stabiliser, increase electrophilicity

site_id	MCSA5
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
G	ARG54	electrostatic stabiliser
G	THR55	electrostatic stabiliser, increase electrophilicity
G	LYS84	proton shuttle (general acid/base)
G	ARG105	electrostatic stabiliser, increase electrophilicity
G	HIS134	electrostatic stabiliser, increase electrophilicity

site_id	MCSA6
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
K	ARG54	electrostatic stabiliser
K	THR55	electrostatic stabiliser, increase electrophilicity
K	LYS84	proton shuttle (general acid/base)
K	ARG105	electrostatic stabiliser, increase electrophilicity
K	HIS134	electrostatic stabiliser, increase electrophilicity

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)