9E94

Cryo-EM structure of human TWIK-2 at pH 7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0005267	molecular_function	potassium channel activity
A	0005765	cellular_component	lysosomal membrane
A	0005886	cellular_component	plasma membrane
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0015271	molecular_function	outward rectifier potassium channel activity
A	0022841	molecular_function	potassium ion leak channel activity
A	0031902	cellular_component	late endosome membrane
A	0062196	biological_process	regulation of lysosome size
A	0071805	biological_process	potassium ion transmembrane transport
A	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
B	0005242	molecular_function	inward rectifier potassium channel activity
B	0005267	molecular_function	potassium channel activity
B	0005765	cellular_component	lysosomal membrane
B	0005886	cellular_component	plasma membrane
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0015271	molecular_function	outward rectifier potassium channel activity
B	0022841	molecular_function	potassium ion leak channel activity
B	0031902	cellular_component	late endosome membrane
B	0062196	biological_process	regulation of lysosome size
B	0071805	biological_process	potassium ion transmembrane transport
B	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Intramembrane: {"description":"Pore-forming; Name=Pore-forming 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Intramembrane: {"description":"Pore-forming; Name=Pore-forming 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Region: {"description":"Selectivity filter 1","evidences":[{"source":"UniProtKB","id":"P57789","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Region: {"description":"Selectivity filter 2","evidences":[{"source":"UniProtKB","id":"P57789","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P57789","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---