9E94
Cryo-EM structure of human TWIK-2 at pH 7.5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005242 | molecular_function | inward rectifier potassium channel activity |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008076 | cellular_component | voltage-gated potassium channel complex |
| A | 0022841 | molecular_function | potassium ion leak channel activity |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0062196 | biological_process | regulation of lysosome size |
| A | 1900227 | biological_process | positive regulation of NLRP3 inflammasome complex assembly |
| B | 0005242 | molecular_function | inward rectifier potassium channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008076 | cellular_component | voltage-gated potassium channel complex |
| B | 0022841 | molecular_function | potassium ion leak channel activity |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0062196 | biological_process | regulation of lysosome size |
| B | 1900227 | biological_process | positive regulation of NLRP3 inflammasome complex assembly |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Pore-forming 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Pore-forming 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 1","evidences":[{"source":"UniProtKB","id":"P57789","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 2","evidences":[{"source":"UniProtKB","id":"P57789","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P57789","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
