9E5Y
T4 Bacteriophage Replicative Polymerase Captured in Polymerase Exchange State 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0034061 | molecular_function | DNA polymerase activity |
| A | 0039686 | biological_process | bidirectional double-stranded viral DNA replication |
| A | 0039693 | biological_process | viral DNA genome replication |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0006260 | biological_process | DNA replication |
| B | 0019083 | biological_process | viral transcription |
| B | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| B | 0039686 | biological_process | bidirectional double-stranded viral DNA replication |
| B | 0039693 | biological_process | viral DNA genome replication |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| C | 0004518 | molecular_function | nuclease activity |
| C | 0004527 | molecular_function | exonuclease activity |
| C | 0006260 | biological_process | DNA replication |
| C | 0006261 | biological_process | DNA-templated DNA replication |
| C | 0008408 | molecular_function | 3'-5' exonuclease activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0034061 | molecular_function | DNA polymerase activity |
| C | 0039686 | biological_process | bidirectional double-stranded viral DNA replication |
| C | 0039693 | biological_process | viral DNA genome replication |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0006260 | biological_process | DNA replication |
| D | 0019083 | biological_process | viral transcription |
| D | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| D | 0039686 | biological_process | bidirectional double-stranded viral DNA replication |
| D | 0039693 | biological_process | viral DNA genome replication |
| E | 0006260 | biological_process | DNA replication |
| E | 0019083 | biological_process | viral transcription |
| E | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| E | 0039686 | biological_process | bidirectional double-stranded viral DNA replication |
| E | 0039693 | biological_process | viral DNA genome replication |
Functional Information from PROSITE/UniProt
| site_id | PS00116 |
| Number of Residues | 9 |
| Details | DNA_POLYMERASE_B DNA polymerase family B signature. AGDTDSVYV |
| Chain | Residue | Details |
| A | ALA616-VAL624 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 472 |
| Details | Region: {"description":"3'-5'exonuclease","evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7592876","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Region: {"description":"Beta hairpin","evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25753811","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1042 |
| Details | Region: {"description":"Polymerase","evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7592876","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"Binding of DNA in B-conformation","evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with the polymerase clamp","evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8917503","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8679562","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Site: {"description":"Optimization of metal coordination by the polymerase active site","evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Site: {"description":"Essential for viral replication","evidences":[{"source":"HAMAP-Rule","id":"MF_04100","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
