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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9E4B

Human ASIC1a at pH 7.5 with domain-swapped transmembrane domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006814biological_processsodium ion transport
A0009986cellular_componentcell surface
A0015280molecular_functionligand-gated sodium channel activity
A0016020cellular_componentmembrane
A0022839molecular_functionmonoatomic ion-gated channel activity
A0022857molecular_functiontransmembrane transporter activity
A0030425cellular_componentdendrite
A0034220biological_processmonoatomic ion transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0050915biological_processsensory perception of sour taste
A0071467biological_processcellular response to pH
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0150052biological_processregulation of postsynapse assembly
A0160128molecular_functionpH-gated monoatomic ion channel activity
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006814biological_processsodium ion transport
B0009986cellular_componentcell surface
B0015280molecular_functionligand-gated sodium channel activity
B0016020cellular_componentmembrane
B0022839molecular_functionmonoatomic ion-gated channel activity
B0022857molecular_functiontransmembrane transporter activity
B0030425cellular_componentdendrite
B0034220biological_processmonoatomic ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0050915biological_processsensory perception of sour taste
B0071467biological_processcellular response to pH
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B0150052biological_processregulation of postsynapse assembly
B0160128molecular_functionpH-gated monoatomic ion channel activity
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006814biological_processsodium ion transport
C0009986cellular_componentcell surface
C0015280molecular_functionligand-gated sodium channel activity
C0016020cellular_componentmembrane
C0022839molecular_functionmonoatomic ion-gated channel activity
C0022857molecular_functiontransmembrane transporter activity
C0030425cellular_componentdendrite
C0034220biological_processmonoatomic ion transmembrane transport
C0035725biological_processsodium ion transmembrane transport
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0050915biological_processsensory perception of sour taste
C0071467biological_processcellular response to pH
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0150052biological_processregulation of postsynapse assembly
C0160128molecular_functionpH-gated monoatomic ion channel activity
Functional Information from PROSITE/UniProt
site_idPS01206
Number of Residues21
DetailsASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC
ChainResidueDetails
ATYR305-CYS325
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1080
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues90
DetailsTransmembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsMotif: {"description":"GAS motif; ion selectivity filter","evidences":[{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsSite: {"description":"Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation","evidences":[{"source":"UniProtKB","id":"Q1XA76","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsSite: {"description":"Involved in the inhibition by the spider venom psalmotoxin-1","evidences":[{"source":"PubMed","id":"19654327","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsSite: {"description":"Involved in proton-dependent gating","evidences":[{"source":"PubMed","id":"19654327","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32915133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CFT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-05-27

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