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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9E2Z

Cryo-EM structure of human CMG helicase stalled at G4-containing DNA template

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
20000166molecular_functionnucleotide binding
20000228cellular_componentnuclear chromosome
20000727biological_processdouble-strand break repair via break-induced replication
20000781cellular_componentchromosome, telomeric region
20000785cellular_componentchromatin
20003677molecular_functionDNA binding
20003678molecular_functionDNA helicase activity
20003688molecular_functionDNA replication origin binding
20003697molecular_functionsingle-stranded DNA binding
20004386molecular_functionhelicase activity
20005515molecular_functionprotein binding
20005524molecular_functionATP binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005664cellular_componentnuclear origin of replication recognition complex
20005694cellular_componentchromosome
20005730cellular_componentnucleolus
20005737cellular_componentcytoplasm
20005829cellular_componentcytosol
20005929cellular_componentcilium
20006260biological_processDNA replication
20006270biological_processDNA replication initiation
20006334biological_processnucleosome assembly
20006915biological_processapoptotic process
20008270molecular_functionzinc ion binding
20016787molecular_functionhydrolase activity
20016887molecular_functionATP hydrolysis activity
20017116molecular_functionsingle-stranded DNA helicase activity
20019899molecular_functionenzyme binding
20030174biological_processregulation of DNA-templated DNA replication initiation
20042393molecular_functionhistone binding
20042555cellular_componentMCM complex
20043138molecular_function3'-5' DNA helicase activity
20046872molecular_functionmetal ion binding
20071162cellular_componentCMG complex
20071353biological_processcellular response to interleukin-4
20090102biological_processcochlea development
21902975biological_processmitotic DNA replication initiation
30000166molecular_functionnucleotide binding
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005515molecular_functionprotein binding
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005658cellular_componentalpha DNA polymerase:primase complex
30005694cellular_componentchromosome
30005730cellular_componentnucleolus
30005737cellular_componentcytoplasm
30006260biological_processDNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30016020cellular_componentmembrane
30016787molecular_functionhydrolase activity
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030174biological_processregulation of DNA-templated DNA replication initiation
30042555cellular_componentMCM complex
30048471cellular_componentperinuclear region of cytoplasm
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
40000166molecular_functionnucleotide binding
40000727biological_processdouble-strand break repair via break-induced replication
40000781cellular_componentchromosome, telomeric region
40003677molecular_functionDNA binding
40003678molecular_functionDNA helicase activity
40003697molecular_functionsingle-stranded DNA binding
40004386molecular_functionhelicase activity
40005515molecular_functionprotein binding
40005524molecular_functionATP binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005694cellular_componentchromosome
40006260biological_processDNA replication
40006271biological_processDNA strand elongation involved in DNA replication
40016020cellular_componentmembrane
40016787molecular_functionhydrolase activity
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40030174biological_processregulation of DNA-templated DNA replication initiation
40042555cellular_componentMCM complex
40071162cellular_componentCMG complex
41902975biological_processmitotic DNA replication initiation
50000166molecular_functionnucleotide binding
50000727biological_processdouble-strand break repair via break-induced replication
50000781cellular_componentchromosome, telomeric region
50003677molecular_functionDNA binding
50003697molecular_functionsingle-stranded DNA binding
50004386molecular_functionhelicase activity
50005515molecular_functionprotein binding
50005524molecular_functionATP binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005694cellular_componentchromosome
50006260biological_processDNA replication
50006270biological_processDNA replication initiation
50016020cellular_componentmembrane
50016787molecular_functionhydrolase activity
50016887molecular_functionATP hydrolysis activity
50017116molecular_functionsingle-stranded DNA helicase activity
50030174biological_processregulation of DNA-templated DNA replication initiation
50042555cellular_componentMCM complex
50043138molecular_function3'-5' DNA helicase activity
50071162cellular_componentCMG complex
60000166molecular_functionnucleotide binding
60000727biological_processdouble-strand break repair via break-induced replication
60000781cellular_componentchromosome, telomeric region
60003677molecular_functionDNA binding
60003678molecular_functionDNA helicase activity
60003697molecular_functionsingle-stranded DNA binding
60004386molecular_functionhelicase activity
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005694cellular_componentchromosome
60005829cellular_componentcytosol
60006260biological_processDNA replication
60016787molecular_functionhydrolase activity
60016887molecular_functionATP hydrolysis activity
60030174biological_processregulation of DNA-templated DNA replication initiation
60042555cellular_componentMCM complex
60042802molecular_functionidentical protein binding
60071162cellular_componentCMG complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000166molecular_functionnucleotide binding
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70000785cellular_componentchromatin
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005694cellular_componentchromosome
70005730cellular_componentnucleolus
70006260biological_processDNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006974biological_processDNA damage response
70008283biological_processcell population proliferation
70009410biological_processresponse to xenobiotic stimulus
70016020cellular_componentmembrane
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030174biological_processregulation of DNA-templated DNA replication initiation
70042325biological_processregulation of phosphorylation
70042555cellular_componentMCM complex
70071162cellular_componentCMG complex
70071364biological_processcellular response to epidermal growth factor stimulus
70071466biological_processcellular response to xenobiotic stimulus
A0000811cellular_componentGINS complex
A0001833biological_processinner cell mass cell proliferation
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0006260biological_processDNA replication
A0071162cellular_componentCMG complex
A1902983biological_processDNA strand elongation involved in mitotic DNA replication
B0000727biological_processdouble-strand break repair via break-induced replication
B0000811cellular_componentGINS complex
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0006260biological_processDNA replication
B0071162cellular_componentCMG complex
C0000811cellular_componentGINS complex
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0006260biological_processDNA replication
C0035264biological_processmulticellular organism growth
C0071162cellular_componentCMG complex
C0090398biological_processcellular senescence
D0000727biological_processdouble-strand break repair via break-induced replication
D0000811cellular_componentGINS complex
D0001833biological_processinner cell mass cell proliferation
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0006260biological_processDNA replication
D0071162cellular_componentCMG complex
E0000076biological_processDNA replication checkpoint signaling
E0000727biological_processdouble-strand break repair via break-induced replication
E0003682molecular_functionchromatin binding
E0003688molecular_functionDNA replication origin binding
E0003697molecular_functionsingle-stranded DNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0005813cellular_componentcentrosome
E0006260biological_processDNA replication
E0006270biological_processDNA replication initiation
E0031261cellular_componentDNA replication preinitiation complex
E0036064cellular_componentciliary basal body
E0071162cellular_componentCMG complex
E1902977biological_processmitotic DNA replication preinitiation complex assembly
Functional Information from PROSITE/UniProt
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GVCCIDEFD
ChainResidueDetails
7GLY440-ASP448
3GLY404-ASP412
4GLY569-ASP577
5GLY440-ASP448
6GLY455-ASP463
2GLY582-ASP590
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues826
DetailsDomain: {"description":"MCM"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues15
DetailsMotif: {"description":"Arginine finger"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues5
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues9
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues31
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P25206","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97311","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues43
DetailsRegion: {"description":"Interaction with RAD17","evidences":[{"source":"PubMed","id":"15538388","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues57
DetailsRegion: {"description":"Important for GINS complex assembly"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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