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9E0W

Cryo-EM structure of human cytoplasmic dynein-1 bound to LIS1 in the presence of ATP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001673cellular_componentmale germ cell nucleus
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005868cellular_componentcytoplasmic dynein complex
A0005874cellular_componentmicrotubule
A0005881cellular_componentcytoplasmic microtubule
A0005938cellular_componentcell cortex
A0007052biological_processmitotic spindle organization
A0007097biological_processnuclear migration
A0008090biological_processretrograde axonal transport
A0008569molecular_functionminus-end-directed microtubule motor activity
A0016020cellular_componentmembrane
A0030175cellular_componentfilopodium
A0030286cellular_componentdynein complex
A0031122biological_processcytoplasmic microtubule organization
A0032388biological_processpositive regulation of intracellular transport
A0033962biological_processP-body assembly
A0034063biological_processstress granule assembly
A0035578cellular_componentazurophil granule lumen
A0042802molecular_functionidentical protein binding
A0045505molecular_functiondynein intermediate chain binding
A0051293biological_processestablishment of spindle localization
A0051301biological_processcell division
A0051959molecular_functiondynein light intermediate chain binding
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0090235biological_processregulation of metaphase plate congression
A0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1904115cellular_componentaxon cytoplasm
A1905832biological_processpositive regulation of spindle assembly
C0000132biological_processestablishment of mitotic spindle orientation
C0000226biological_processmicrotubule cytoskeleton organization
C0000235cellular_componentastral microtubule
C0000776cellular_componentkinetochore
C0001675biological_processacrosome assembly
C0001764biological_processneuron migration
C0005515molecular_functionprotein binding
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005871cellular_componentkinesin complex
C0005874cellular_componentmicrotubule
C0005875cellular_componentmicrotubule associated complex
C0005881cellular_componentcytoplasmic microtubule
C0005938cellular_componentcell cortex
C0006629biological_processlipid metabolic process
C0007017biological_processmicrotubule-based process
C0007097biological_processnuclear migration
C0007268biological_processchemical synaptic transmission
C0007281biological_processgerm cell development
C0007399biological_processnervous system development
C0007405biological_processneuroblast proliferation
C0007611biological_processlearning or memory
C0008017molecular_functionmicrotubule binding
C0008090biological_processretrograde axonal transport
C0008201molecular_functionheparin binding
C0008247cellular_component1-alkyl-2-acetylglycerophosphocholine esterase complex
C0008344biological_processadult locomotory behavior
C0010977biological_processnegative regulation of neuron projection development
C0015630cellular_componentmicrotubule cytoskeleton
C0016042biological_processlipid catabolic process
C0017145biological_processstem cell division
C0019226biological_processtransmission of nerve impulse
C0021540biological_processcorpus callosum morphogenesis
C0021766biological_processhippocampus development
C0021819biological_processlayer formation in cerebral cortex
C0021895biological_processcerebral cortex neuron differentiation
C0021987biological_processcerebral cortex development
C0030036biological_processactin cytoskeleton organization
C0030154biological_processcell differentiation
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0030900biological_processforebrain development
C0031023biological_processmicrotubule organizing center organization
C0031252cellular_componentcell leading edge
C0031514cellular_componentmotile cilium
C0031965cellular_componentnuclear membrane
C0031982cellular_componentvesicle
C0032420cellular_componentstereocilium
C0034452molecular_functiondynactin binding
C0038026biological_processreelin-mediated signaling pathway
C0040019biological_processpositive regulation of embryonic development
C0042249biological_processestablishment of planar polarity of embryonic epithelium
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043274molecular_functionphospholipase binding
C0043622biological_processcortical microtubule organization
C0044877molecular_functionprotein-containing complex binding
C0045505molecular_functiondynein intermediate chain binding
C0045773biological_processpositive regulation of axon extension
C0045931biological_processpositive regulation of mitotic cell cycle
C0046469biological_processplatelet activating factor metabolic process
C0046982molecular_functionprotein heterodimerization activity
C0047496biological_processvesicle transport along microtubule
C0048471cellular_componentperinuclear region of cytoplasm
C0048854biological_processbrain morphogenesis
C0050804biological_processmodulation of chemical synaptic transmission
C0050885biological_processneuromuscular process controlling balance
C0051010molecular_functionmicrotubule plus-end binding
C0051012biological_processmicrotubule sliding
C0051130biological_processpositive regulation of cellular component organization
C0051219molecular_functionphosphoprotein binding
C0051301biological_processcell division
C0051656biological_processestablishment of organelle localization
C0051660biological_processestablishment of centrosome localization
C0060117biological_processauditory receptor cell development
C0061003biological_processpositive regulation of dendritic spine morphogenesis
C0062234biological_processplatelet activating factor catabolic process
C0070062cellular_componentextracellular exosome
C0070507biological_processregulation of microtubule cytoskeleton organization
C0070840molecular_functiondynein complex binding
C0090102biological_processcochlea development
C0090176biological_processmicrotubule cytoskeleton organization involved in establishment of planar polarity
C0090724cellular_componentcentral region of growth cone
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098978cellular_componentglutamatergic synapse
C0099175biological_processregulation of postsynapse organization
C1904115cellular_componentaxon cytoplasm
Functional Information from PROSITE/UniProt
site_idPS00374
Number of Residues7
DetailsMGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV
ChainResidueDetails
AILE-40-VAL-34

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS
ChainResidueDetails
AILE2216-SER2226

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LASCsaDmTIKLWDF
ChainResidueDetails
CLEU165-PHE179
CILE207-VAL221
CLEU311-VAL325
CVAL395-CYS409

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues249
DetailsRegion: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues269
DetailsRegion: {"description":"AAA 4","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues229
DetailsRegion: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues216
DetailsRegion: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues63
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues28
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues41
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues39
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues39
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues39
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues41
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues32
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues42
DetailsRegion: {"description":"Interaction with DCX","evidences":[{"source":"PubMed","id":"11001923","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues22
DetailsRegion: {"description":"Interaction with NDEL1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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