Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9DVP

Structure of the phosphate exporter XPR1/SLC53A1, Pi and InsP8-bound, intracellular gate closed state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000822	molecular_function	inositol hexakisphosphate binding
A	0001618	molecular_function	virus receptor activity
A	0005315	molecular_function	phosphate transmembrane transporter activity
A	0005886	cellular_component	plasma membrane
A	0006817	biological_process	phosphate ion transport
A	0009615	biological_process	response to virus
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0016036	biological_process	cellular response to phosphate starvation
A	0030643	biological_process	intracellular phosphate ion homeostasis
A	0035435	biological_process	phosphate ion transmembrane transport
A	0046718	biological_process	symbiont entry into host cell
B	0000822	molecular_function	inositol hexakisphosphate binding
B	0001618	molecular_function	virus receptor activity
B	0005315	molecular_function	phosphate transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0006817	biological_process	phosphate ion transport
B	0009615	biological_process	response to virus
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0016036	biological_process	cellular response to phosphate starvation
B	0030643	biological_process	intracellular phosphate ion homeostasis
B	0035435	biological_process	phosphate ion transmembrane transport
B	0046718	biological_process	symbiont entry into host cell

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	70
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	34
Details	Intramembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	62
Details	Transmembrane: {"description":"Discontinuously helical; Name=9","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J4X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J53","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	14
Details	Region: {"description":"Important for inositol polyphosphate binding","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8X5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8X5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9IJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9J52","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Site: {"description":"Gating residue for phosphate transport","evidences":[{"source":"PubMed","id":"39169184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39325866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39747008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39814721","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)